A5103010239- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Management of metastatic bone disease
- Cancer Diagnosis and Treatment
- Bone fractures and treatments
- Bone health and treatments
- Shoulder Injury and Treatment
- Total Knee Arthroplasty Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Shoulder and Clavicle Injuries
- Aortic aneurysm repair treatments
- Cardiac Valve Diseases and Treatments
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Neuroblastoma Research and Treatments
- Aortic Disease and Treatment Approaches
- Cardiac, Anesthesia and Surgical Outcomes
- Soft tissue tumors and treatment
- Hip disorders and treatments
- Mechanical Circulatory Support Devices
- Oral and Maxillofacial Pathology
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Orthopedic Infections and Treatments
- Cardiac tumors and thrombi
University of Pittsburgh Medical Center
2005-2020
Shadyside Hospital
1995-2020
Tel Aviv University
2018
University of Pittsburgh
1984-2017
UPMC Hillman Cancer Center
2014
UPMC Presbyterian
1979-2013
University of Sheffield
2005-2010
Mount Medical Centre
2006
Royal Perth Hospital
1996-1997
MedStar Union Memorial Hospital
1996
The concept of staging malignant tumors arose in re sponse to the need for meaningful assessment various methods treatment end-result studies. Its purpose was ensure that lesions comparable prognostic import were used evaluate management, so one form not inadvertently biased by inclu sion a preponderance favorable while another method adversely weighted on basis with unfavorable predictors. first system developed carcinoma cervix . predictors local invasion, regional metastases lymph nodes,...
William Fisher Enneking (Fig 1) was born in Madison, WI May 1926. He earned his BS and MD degrees at the University of Wisconsin 1946 1949, respectively. served US Navy during World War II (1943–1944) again Korean from 1950 to 1962. His career orthopaedics started with residency Chicago (1952–1955). A year later, he became Chief Orthopaedics Mississippi 1960, Florida Gainesville. has published numerous papers on musculoskeletal oncology including this classic article, which defines a system...
Four small round cell malignant tumors of bone occurring in children are described. There was no catecholamine secretion and the clinical, radiologic, biopsy diagnosis each Ewing's sarcoma. Glycogen sparse both on imprints tissue sections. The tumors, when extensively sampled, had areas a lobular growth pattern Homer Wright rosettes. rosettes were always focal varied complexity from case to case; they rudimentary one instance markedly fibrillar most obvious instance. Neuron-specific enolase...
Thirty-five college athletes with lower leg pain underwent radiography and radionuclide studies to rule out a stress fracture. Their asymptomatic extremities 13 pain-free served as controls. Four main patterns were observed: (a) sharply marginated scintigraphic abnormalities positive radiographs; (b) negative (c) ill-defined (d) images radiographs. Since the patients first two otherwise identical medically, authors feel that this appearance is characteristic of bone in appropriate clinical...
Objective This collaboration between the American College of Rheumatology and Association Hip Knee Surgeons developed an evidence‐based guideline for perioperative management antirheumatic drug therapy adults with rheumatoid arthritis (RA), spondyloarthritis (SpA) including ankylosing spondylitis psoriatic arthritis, juvenile idiopathic (JIA), or systemic lupus erythematosus (SLE) undergoing elective total hip (THA) knee arthroplasty (TKA). Methods A panel rheumatologists, orthopedic...
Diffuse-type pigmented villonodular synovitis (PVNS) has a high local recurrence rate and as such can lead to erosive destruction of the involved joint. Multiple surgical modalities exist, but it is unknown which technique best minimizes morbidity.We compared rates, arthritis progression, complications between arthroscopic open for diffuse PVNS knee.We retrospectively identified 103 patients with treated 1993 2011. Of these, 48 had diffuse-type knee by all-arthroscopic, posterior anterior,...
Osteosarcoma (OS), chondrosarcoma (CSA), and Ewings sarcoma (ES) are the most common primary malignancies of bone, rare diseases. As with all sarcomas, prognosis these diseases ultimately depends on presence metastatic disease. Survival is therefore closely linked biology potential a particular bone tumor's cells. Here we describe significant correlation aldehyde dehydrogenase (ALDH) activity presence/absence distant metastases in ten consecutive cases human sarcomas. Additionally, cultured...
Abstract Background Chondromyxoid fibromas (CMFs) are rare benign chondroid/myxoid matrix-producing tumors that occur in metaphyses of long tubular bones, and very rarely small bones hands feet. Flat bone involvement is even more uncommon. Prior cytogenetic analyses have identified complex abnormalities involving chromosome 6 the majority cases. Methods A search for CMF over an 8-year period (1999–2006) from surgical pathology files our institution yielded 16 Four cases occurred relatively...
Eighteen patients with primary osteosarcoma were studied for abnormal endocrinologic functions. Oral glucose tolerance tests revealed glucose, insulin, or growth hormone response curves in 78% of the study population. Elevated somatomedin values noted 72% tested. No significant deviations observed serum cortisol, estradiol, testosterone, follicle stimulating hormone, and luteinizing levels. Likewise, lipid screening 24 hour 17-hydroxy 17-keto steroid excretion levels normal. Statistically...
The transcription factor Sox9 is known to play a crucial role in normal chondrogenesis, and antibodies against have been proposed as diagnostic tool for neoplasms with chondroid differentiation. However, the pattern of immunohistochemical expression by other bone soft tissue neoplasms, well its specificity, remain unexplored. authors performed immunohistochemistry 106 nonchondroid neoplasms. Moderate intense nuclear staining was observed 14/20 chondrosarcomas (70%), 24/81 (29.6%) cases from...
Melanoma metastatic to bone carries a poor prognosis with overall median survival in the 4-6 months range. Others have published data that suggest resection of isolated visceral organ metastases improves survival. We conducted retrospective analysis 130 cases stage IV melanoma pathologically confirmed bony disease. used Cox regression compare group patients who underwent wide those received other surgery or were treated nonoperatively. also compared three groups against matched historical...
Osteomyelitis of the clavicle is an uncommon disease, but it should be considered in patients who present with pain, cellulitis, or drainage sternoclavicular area following head and neck surgery, irradiation, subclavian vein catheterization, immunosuppression. An idiopathic presentation possible. In contrast to primary osteomyelitis clavicle, which occasionally seen children, secondary quite rare. It often mistaken for a fracture possible neoplasm on plain x-rays. Tomograms CT scanning are...
Abstract Avascular necrosis of bone (AVNB) is a known complication systemic adrenocorti‐costeroid therapy, and one which thought to be dose‐related. However, despite the large amounts prednisone have been used in standard treatment acute lymphocytic leukemia (ALL), AVNB rarely has reported children with that disease. We described our experience adolescent ALL who developed multifocal presenting as pain after aggressive chemotherapy included high cumulative dose corticosteroids well other...