A5101781502- Magnesium Alloys: Properties and Applications
- Hydrogen Storage and Materials
- Aluminum Alloys Composites Properties
- Orthopaedic implants and arthroplasty
- Corrosion Behavior and Inhibition
- Bone Tissue Engineering Materials
- Wound Healing and Treatments
- Periodontal Regeneration and Treatments
- Recycling and Waste Management Techniques
- High Altitude and Hypoxia
- Mesoporous Materials and Catalysis
- Metallurgy and Material Science
- Electrospun Nanofibers in Biomedical Applications
- Cancer, Hypoxia, and Metabolism
- Mesenchymal stem cell research
Shanghai Jiao Tong University
2009-2016
Shanghai Sixth People's Hospital
2009-2016
Zhejiang University
2004
In this study, magnesium-zinc (Mg-Zn) alloy was investigated as a biodegradable orthopedic implant. MC3T3-E1 cell attachment, mineralization and osteogenic-specific mRNA expression were assessed for measurements of the in vitro biocompatibility Mg-Zn alloy. vivo degradation accompanying new bone formation femoral marrow cavity analyzed by scanning electron microscopy histomorphological analysis. Results showed that cells cultured on samples manifested better attachment ability, well improved...
Traditional therapeutic methods for skin wounds have many disadvantages, and new wound dressings that can facilitate the healing process are thus urgently needed. Platelet-rich plasma (PRP) contains multiple growth factors (GFs) shows a significant capacity to heal soft tissue wounds. However, these GFs short half-life deactivate rapidly; we therefore need sustained delivery system overcome this shortcoming. In study, poly(d,l-lactide)-poly(ethylene glycol)-poly(d,l-lactide)...
It is desirable for orthopaedic implants to possess good osteointegration and anti-biofilm ability simultaneously the prevention of implant associated infections promotion osteointegration.
In the present study, effects of Mg-Nd-Zn-Zr (JDBM), brushite (CaHPO4·2H2O)-coated JDBM (C-JDBM), AZ31, WE43, pure magnesium (Mg) and Ti alloy (TC4) on rabbit chondrocytes were investigated in vitro. Adhesion experiments revealed satisfactory morphology surface all samples. An indirect cytotoxicity test using MTT assay that C‑JDBM TC4 exhibited results similar to those negative control, better than obtained with JDBM, WE43 Mg (p<0.05). There no statistically significant differences observed...
In this study a calcium phosphate (Ca–P) coating was fabricated on the surface of an AZ31 alloy by chemical deposition process, and in vitro vivo studies were carried out Ca–P-coated uncoated to determine effect Ca–P corrosion behavior biocompatibility alloy. The morphology composition characterized scanning electron microscopy energy dispersive spectroscopy. Ca-P evaluated static immersion test effects also investigated cell experiments animal experiments. results indicated that reduced...
This study aimed to investigate the effects of a novel patented Mg-3Nd-0.2Zn-0.4Zr (weight %, JDBM) alloy on osteoblastic cell function, as these cells play an important role in bone repair and remodeling. The associated JDBM function involving adhesion, proliferation, mineralization were investigated using scanning electron microscopy (SEM), MTT assay ambramycin staining, respectively. At same time, vitro degradation behavior culture medium was evaluated by weight-loss method SEM. Pure...
Angiogenesis and osteogenesis coupling processes are essential for bone regeneration, human marrow stromal cells (hBMSCs) along with endothelial (ECs) crucial participants. Deferoxamine (DFO), a hypoxia-mimetic agent, could activate the hypoxia-inducible factor (HIF)-1α signaling pathway trigger angiogenic osteogenic effects in these cells. However, lifetime of DFO is very short, thus suitable delivery system urgently needed. In this study, we encapsulated...