A5100337033- Phytochemical compounds biological activities
- RNA modifications and cancer
- Postharvest Quality and Shelf Life Management
- Plant Physiology and Cultivation Studies
- Natural product bioactivities and synthesis
- Esophageal Cancer Research and Treatment
- Fungal Biology and Applications
- Horticultural and Viticultural Research
- DNA Repair Mechanisms
- Angiogenesis and VEGF in Cancer
- Lung Cancer Diagnosis and Treatment
- Traditional and Medicinal Uses of Annonaceae
- Gut microbiota and health
- Cancer, Hypoxia, and Metabolism
- Cancer-related Molecular Pathways
- Cancer Research and Treatments
- Pineapple and bromelain studies
- Botanical Research and Applications
- Mycobacterium research and diagnosis
- Pancreatic and Hepatic Oncology Research
- Sesquiterpenes and Asteraceae Studies
- RNA Research and Splicing
- Phytochemistry and Bioactive Compounds
- Ginseng Biological Effects and Applications
- Cancer, Lipids, and Metabolism
Ministry of Agriculture and Rural Affairs
2024
Institute of Pomology
2024
Citrus Research Institute
2024
Southwest University
2024
University of Chinese Academy of Sciences
2022
Chinese Academy of Sciences
2022
Wuhan Botanical Garden
2022
Fourth Hospital of Hebei Medical University
2019-2021
Hebei Medical University
2019-2021
Shanghai Jiao Tong University
2014
Abstract Therapeutic antibodies targeting PD-1 have made major breakthroughs in cancer treatment. However, the majority of colorectal (CRC) cases are microsatellite stable (MSS) and do not respond to anti-PD-1-based immunotherapy. Combination therapy will be an ideal strategy overcome this limitation. Gegen Qinlian decoction (GQD), a classical traditional Chinese medicine (TCM) formula, has been clinically proven effective treatment ulcerative colitis (UC) type 2 diabetes mellitus. Here,...
(±)-Quassidines I (1) and J (2), two pairs of new bis-β-carboline alkaloid enantiomers, were isolated from the stems Picrasma quassioides. Their structures determined by analysis spectroscopic data, including HRESIMS 2D NMR, confirmed single-crystal X-ray diffraction analysis. The racemic mixtures 1 2 resolved into (+)-S-1a (−)-R-1b (+)-S-2a (−)-R-2b, HPLC using a chiral Daicel IB-3 column, respectively, which represents first successful example to resolve mixtures. absolute configurations...
Pears are popular among consumers for their juicy and delicious taste. In this study, the sugar organic acid compositions of pear fruits with different texture types during development were determined by ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS), fruit traits a analyzer. The results showed that dominant in soft crispy was fructose. main difference between pears second-highest component; glucose content higher crispy-flesh while sucrose soft-flesh fruits....
This study aims to investigate effects of checkpoint kinase, mediator DNA damage 1 (MDC1) and p53-binding protein (53BP1) silencing on p53, kinase 2 (CHK1 CHK2), CHK2-T68 expression.Eca109 cells were divided into untransfected Eca109, Blank-vector, MDC1-RNAi transfection, 53BP1-RNAi transfection group. Streptavidin-peroxidase (SP) immunohistochemical assay was used examine expression. About 4 groups establish esophageal carcinoma nude-mouse models, assigned as Eca-109 control (or plus 15 Gy...
Colorectal cancer (CRC) is the third most common worldwide. At present, there are limited effective biomarkers of CRC. The present study aimed to identify potential signatures associated with tumorigenesis and prognosis CRC using publicly available databases, further validate identified in cell lines. Identification differentially expressed mRNAs between paracancerous samples was conducted based on data from Cancer Genome Atlas (TCGA; 471 tumor 41 normal samples). Survival analysis performed...
Background: To study the anti-cancer effect of isoalantolactone, a sesquiterpene lactoneisolated from roots Inula heleniumon human gynecologic cancer cells. Methods: A structure-activity relationship experiment was designed to identify functional moiety isoalantolactone for its significant activity. Five cell lines were treated with isoalantolactone. Cell proliferation determined by MTT assay in vitro and apoptosis flow cytometry. Results: We found strongly inhibited proliferationofHEC-1,...
Background To investigate the anticancer effects of limonoid compounds that were isolated and purified from Xylocarpus granatum fruits on human esophageal cancer (EC) cells. A structure‐activity relationship experiment was designed to identify functional moiety identified as being critical for its activity. Methods Eca109 cells cultured in RPMI1640 medium treated with compounds. Cell proliferation determined by MTT assay vitro. apoptosis analyzed flow cytometry after xylogranatin C. The...
e16516 Background: We aimed to study the anti-cancer effects of limonoid compounds that were isolated and purified from Xylocarpus granatum fruits on human esophageal cancer cells. A structure-activity relationship experiment was designed identify functional moiety identified as being critical for its activity. Methods: Esophageal Eca109 cells treated with compounds. Cell proliferation determined by MTT assay in vitro cellular apoptosis flow cytometry Western Immunolotting. Results: Four...