A5101908216- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Lung Cancer Treatments and Mutations
- Ferroptosis and cancer prognosis
- Advanced Sensor and Control Systems
- Adaptive Control of Nonlinear Systems
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Immune Cell Function and Interaction
- Advanced Algorithms and Applications
- Neurological Disorders and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Traditional Chinese Medicine Studies
- Health disparities and outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Health and Disease Prevention
- Meta-analysis and systematic reviews
- Cancer Genomics and Diagnostics
- Industrial Technology and Control Systems
- Embedded Systems and FPGA Design
- Medical Research and Treatments
- Ideological and Political Education
- Imbalanced Data Classification Techniques
Qingdao University of Technology
2008-2025
Shandong First Medical University
2014-2025
Shandong Tumor Hospital
2014-2025
Weifang Medical University
2012-2024
Jiangxi University of Traditional Chinese Medicine
2011-2024
Central Hospital of Zibo
2024
The First Affiliated Hospital, Sun Yat-sen University
2023
Fudan University
2023
Sun Yat-sen University
2023
Capital Medical University
2023
Abstract Background The COVID-19 has caused a sizeable global outbreak and been declared as public health emergency of international concern. Sufficient evidence shows that temperature an essential link with respiratory infectious diseases. objectives this study were to describe the exposure-response relationship between ambient temperature, including extreme temperatures, mortality COVID-19. Methods Poisson distributed lag non-linear model (DLNM) was constructed evaluate delayed effects on...
Abstract Immune checkpoint inhibitors (ICIs) are most commonly used for melanoma and non-small cell lung cancer (NSCLC) patients. FAT atypical cadherin 1 (FAT1), which frequently mutates in NSCLC. In this study, we aim to investigate the association of FAT1 mutations with ICI response outcome. We collected somatic mutation profiles clinical information from ICI-treated 631 109 NSCLC samples, respectively. For validation, a pan-cancer cohort 1661 patients an immunotherapy setting was also...
Abstract Purpose Protein tyrosine phosphatase receptor type T (PTPRT), which is a well‐known and mutates frequently in melanoma non‐small cell lung cancer (NSCLC). Our research aims to elucidate its mutation association with immune checkpoint inhibitors (ICI) efficacy. Methods We integrated whole‐exome sequencing (WES) ‐ based somatic profiles clinical characteristics of 631 samples received ICI agents from eight studies 109 NSCLC two studies. For validation, 321 350 immunotherapy targeted...
Background Immune checkpoint inhibitor (ICI) therapy dramatically prolongs melanoma survival. Currently, the identified ICI markers are sometimes ineffective. The objective of this study was to identify novel determinants efficacy. Methods We comprehensively curated pretreatment somatic mutational profiles and clinical information from 631 patients who received blockade immune checkpoints (i.e., CTLA-4, PD-1/PD-L1, or a combination). Significantly mutated genes (SMGs), signatures, potential...
The Symptom Checklist (SCL) developed by the Health Behaviour in School‑aged Children (HBSC) study is widely used to capture psychosomatic complaints (PSC) of non-clinical children and adolescents. Although its psychometric properties have been well established internationally, performance Mandarin Chinese version remains unclear. This evaluates HBSC-SCL's properties, develops norm, creates corresponding scoring algorithm. Data were collected from a two-wave cross-sectional survey conducted...
Neoadjuvant therapy is widely used for esophageal cancer (EC), but optimal treatment regimens and predictive factors outcomes remain unclear. This study retrospectively analyzed data from EC patients who underwent neoadjuvant therapy. The chi-square test or Fisher's exact was utilized to examine differences in general clinicopathological between benefit groups. Survival analyses were conducted using Kaplan-Meier methods. Cox univariate multivariate regression employed identify independent...
The study aims to investigate the role of 18F-alfatide positron emission tomography/computed tomography (PET/CT) in predicting short-term outcome concurrent chemoradiotherapy (CCRT) patients with advanced non-small cell lung cancer (NSCLC).Eighteen NSCLC had undergone PET/CT scans before CCRT and parameters including maximum mean standard uptake values (SUVmax/SUVmean), peak (SUVpeak) tumor volume (TVPET TVCT) were obtained. SUVmax normal tissues (lung, blood pool muscle) measured, their...
To perform a dosimetric evaluation of four different simultaneous integrated boost whole brain radiotherapy modalities with hippocampus and inner ear avoidance in the treatment limited metastases. Computed tomography/magnetic resonance imaging data 10 patients (1–5) metastases were used to replan step-and-shoot intensity-modulated (sIMRT), dynamic radiation therapy (dIMRT), volumetric-modulated arc (VMAT), helical tomotherapy (Tomo). The prescribed doses 40–50 Gy fractions 30 simultaneously...
Abstract Background Gonorrhea has long been a serious public health problem in mainland China that requires attention, modeling to describe and predict its prevalence patterns can help the government develop more scientific interventions. Methods Time series (TS) data of gonorrhea incidence from January 2004 August 2022 were collected, with September 2021 as validation. The seasonal autoregressive integrated moving average (SARIMA) model, short-term memory network (LSTM) hybrid SARIMA-LSTM...
Despite the acknowledged sex-related differences in immune response and checkpoint inhibitor (ICI) efficacy, little is known about sex disparities melanoma of novel genomic determinants for ICI therapies.Pretreatment profiles clinical characteristics 631 patients treated with ICIs (i.e., inhibitors CTLA-4, PD-1/PD-L1, or both) were comprehensively curated. Genomic factors, i.e., significantly mutated genes (SMGs), mutational signatures, molecular subtypes identified, their associations...
Metabolic syndrome (MetS) is correlated with arterial stiffness and can be evaluated by brachial-ankle pulse wave velocity (baPWV). We investigated potential associations between MetS baPWV in a Chinese community population. The community-based Asymptomatic Polyvascular Abnormalities Community study examined asymptomatic polyvascular abnormalities population aged ≥40 years. relationship its components was analyzed multivariate logistic linear regression models. Out of 5181 participants, 1271...
Abstract Background There were amounts of previous studies on chronic diseases, but few the prevalence disease and healthy lifestyle intervention in recent years, China. This study aimed to investigate implementation rural areas China, so as put forward health promotion measures control diseases effectively. Method A large cross-sectional ( N = 2168) community diagnosis was carried out Shandong province, The questionnaire questionnaires recruited survey intervention. Physical examination...
Background: The objective of this study was to investigate the use ensemble methods improve prediction fetal macrosomia and large for gestational age from prenatal ultrasound imaging measurements. Methods: We evaluated compared accuracies nonlinear quadratic mixed-effects models coupled with 26 different empirical formulas estimating weights in predicting fetuses at birth. data investigation were taken Successive Small-for-Gestational-Age-Births study. Ensemble methods, a class machine...
Aging has been demonstrated to play vital roles in the prognosis and treatment efficacy of cancers, including lung adenocarcinoma (LUAD). This novel study aimed construct an aging-related risk signature evaluate immunogenicity LUAD. Transcriptomic profiles clinical information were collected from a total 2518 LUAD patients 12 independent cohorts. The was developed by combining specific gene expression with corresponding regression coefficients. One cohort treated immune checkpoint inhibitor...
Immune checkpoint inhibitors (ICIs) markedly promote the survival outcome of advanced melanoma and non-small cell lung cancer (NSCLC). Clinically, favorable ICI treatment efficacy is noticed only in a smaller proportion patients. Heparan sulfate proteoglycan 2 (HSPG2) frequently mutates both tumors. Herein, we aim to investigate immunotherapeutic immunological roles HSPG2 mutations NSCLC. A total 631 samples 109 NSCLC with somatic mutational profiles clinical immunotherapy data were curated....
Aspergillus species are becoming a major public health concern worldwide due to the increase in incidence of aspergillosis and emergence antifungal resistance. In this study, we surveyed all isolated from patients Zhongshan Hospital Fudan University, Shanghai, China, 2019 2021.We characterized susceptibility profiles these medical azoles (voriconazole, itraconazole posaconazole) using YeastOneTM broth microdilution system. To determine underlying resistance mechanisms azole-resistant A....
This study was aimed to compare and analyze the effects safety of minimally invasive craniotomy in treatment hypertensive intracerebral hemorrhage.A total 130 patients with hemorrhage were recruited. The randomly divided into two groups (research control group). Research group treated endoscopic surgery, while hematoma clearance. basic situation, clinical effects, prognosis, nerve function inflammatory factors compared condition postoperative complications also observed.The operative time...
Sustainable economic development is a hot issue in current research, and it of great significance to analyze the effects air pollution population agglomeration on sustainable development. This study collects relevant data released by Chinese government from 2011–2021, empirically analyzes method constructing an individual one-factor fixed-effects model order explore impacts SO 2 emissions Through analysis, found that are negatively correlated with development, direction intensity its...
At the end of 2019, outbreak coronavirus disease 2019 (COVID-19) severely damaged and endangered people's lives. The public health emergency management system in China has played an essential role handling response to outbreak, which been appreciated by World Health Organization some countries. Hence, it is necessary conduct overall analysis development China. This can provide a reference for scholars aid understanding current situation reveal new research topics.We collected 2247...