A5003398200- Asthma and respiratory diseases
- Breastfeeding Practices and Influences
- Epigenetics and DNA Methylation
- Food Allergy and Anaphylaxis Research
- IL-33, ST2, and ILC Pathways
- Neonatal Respiratory Health Research
- Child Nutrition and Feeding Issues
- Child Welfare and Adoption
- Child Abuse and Trauma
- Eosinophilic Esophagitis
- Intergenerational Family Dynamics and Caregiving
- Pediatric health and respiratory diseases
- Dermatology and Skin Diseases
- Genomics and Phylogenetic Studies
- Plant Disease Resistance and Genetics
- Microbial Community Ecology and Physiology
- Infant Nutrition and Health
- Urticaria and Related Conditions
- Birth, Development, and Health
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Gestational Diabetes Research and Management
- Infant Development and Preterm Care
- Plant and soil sciences
- Historical Medical Research and Treatments
- Infant Health and Development
University of South Carolina
2012-2024
University of Southampton
2018
University of Memphis
2013-2016
University of South Carolina Sumter
2008-2013
University of Puerto Rico-Mayaguez
2007-2009
The occurrence of asthma is weakly explained by known genetic variants. Epigenetic marks, DNA methylation (DNA-M) in particular, are considered to add the explanation asthma. However, no etiological model has yet been developed that integrates variants and DNA-M. To explore a new model, we focused on one candidate gene, IL-4 receptor (IL4R). We hypothesized IL4R interaction with DNA-M at cytosine-phosphate-guanine (CpG) sites jointly alter risk during adolescence. Blood samples were...
Season of birth influences allergy risk; however, the biological mechanisms underlying this observation are unclear. The environment affects DNA methylation, with potentially long-lasting effects on gene expression and disease. This study examined whether methylation could underlie association between season allergy.
Background: The prevalence of allergic diseases are increasing worldwide, emphasizing the need to elucidate their pathogeneses.The aims this study were use a two-stage design identify DNA methylation levels at cytosine-phosphate-guanine (CpG) sites across genome associated with atopy and high serum immunoglobulin E (IgE), then replicate our findings in an independent cohort.Methods: Atopy was assessed via skin prick tests IgE.Methylation measured from whole blood using Illumina Infinium...
An aerobic, moderately halophilic, Gram-negative, motile, non-sporulating rod-shaped bacterium, designated strain A10T, was isolated from the surface of leaves black mangrove Avicennia germinans and subjected to a polyphasic taxonomic study. Strain A10T able grow at NaCl concentrations in range 5–17.5 % (w/v) with optimum growth 10 NaCl. Growth occurred temperatures 20–40 °C (optimal 37 °C) pH 5.5–8.5 7.0–8.0). The major respiratory quinone ubiquinone 9. fatty acids were C16 : 0, C18 1 ω7c,...
Controversies regarding infant feeding and childhood wheezing may result from insufficient differentiation among various modes.We conducted prospective analyses of associations between the repeated ascertainment mode in infancy.The Infant Feeding Practices Study II (2833 infants) provided data on coughing/wheezing episodes (CWEs) at 8 time points modes 9 months 1 to 12. were defined as direct breastfeeding, indirect breastfeeding (IBF, bottled breast milk), formula (FF), their combinations....
Genetic effects on asthma of genes in the T-helper 2 (Th2) pathway may interact with epigenetic factors including DNA methylation. We hypothesized that interactions between genetic variants and methylation this (IL4, IL4R, IL13, GATA3, STAT6) influence risk, such influences are age-dependent, some CpG sites changes over time accordance transition. tested these hypotheses subsamples girls from a population-based birth cohort established Isle Wight, UK, 1989.Logistic regression models were...
WHO guidelines advocate breastfeeding for 6 months, and EAACI guideline recommends exclusive 4-6 months. However, evidence to prevent asthma allergic disease is conflicting. We examined whether following recommended alters the long-term risks of asthma, eczema, rhinitis or atopy.The effect nonexclusive (0, >0-6, >6 months) >0-4, >4 on repeated measures (10, 18 years), rhinitis, atopy (1-or-2, 4, 10, years) was estimated in IoW cohort (n = 1456) using log-linear models with generalized...
Breastfeeding is protective against many long-term diseases, yet the mechanisms involved are unknown. Leptin gene (LEP) reported to be associated with body mass index (BMI). On other hand, breastfeeding duration has been found DNA methylation (DNAm) of LEP gene. Therefore, epigenetic regulation may represent mechanism underlying effect obesity. In Isle Wight Birth Cohort, peripheral blood DNAm at 23 cytosine-phosphate-guanine sites (CpGs) in locus 10-year-old (n = 297) samples and 16 CpGs...
Background: In settings in which diseases wax and wane, there is a need to measure disease dynamics longitudinal studies. Traditional measures of occurrence (eg, cumulative incidence) do not address change or stability are limited stable cohorts may thus lead erroneous conclusions. To illustrate how different can be used detect dynamics, we investigated sex differences the asthma wheezing, using population-based study cohort that covered first 18 years life.Methods: Isle Wight birth (n =...
Asthma is characterized by airflow limitation and airway reactivity (AR). Interleukin-13 (IL-13) involved in the pathogenesis of asthma. Two functional SNPs, rs20541 rs1800925, IL-13 gene (IL13) have been frequently associated with asthma-related lung functions. However, genetic variation alone does not fully explain asthma risk. DNA-methylation (DNA-M) an epigenetic mechanism that regulates expression can be influenced both environment variants. To explore interplay prenatal maternal...
Breastfeeding has been linked with increased forced vital capacity (FVC) in children but not older adolescents. Our aim was to investigate the effects of breastfeeding duration and infant weight gain on FVC both developmental periods. In a birth cohort, information collected at 1 2 yrs; spirometric tests were conducted 10 18 yrs. To estimate effect yrs age, we used linear models; analyse repeated measurements mixed models. Links between breastfeeding, age analysed through path analyses....
Background: Gastroesophageal reflux in neonates is frequently reported by parents, potentially motivating changes infant feeding mode and/or addition of solid food. Objective: The authors prospectively analyzed associations between repeated measurement modes and infancy. Methods: Infant Feeding Practices Study II, conducted 2005 2007 (2,841 infants), provides data on at nine time points from months 1 to 12. were defined based direct breastfeeding, bottled human milk, formula feeding, their...
A moderately halophilic, spore-forming, Gram-positive, short-rod-shaped bacterium, designated strain MS10(T), was isolated from the surface of leaves black mangrove Avicennia germinans and subjected to a polyphasic taxonomic study. Strain MS10(T) able grow at NaCl concentrations in range 5-20% (w/v) with optimum growth 10% NaCl. Growth occurred temperatures 10-50 degrees C (optimal 33-35 C) pH 6.0-9.0 7.0). Phylogenetic analysis based on 16S rRNA gene sequence comparisons revealed that fell...
The role of breast milk on the risk childhood asthma is in dispute. aim this prospective study to determine relationship immune markers maternal serum during gestation and asthma-like symptoms (AS) infancy.Pregnant women were recruited Columbia Charleston, South Carolina. Blood (median: three weeks before delivery) (three after samples collected. Concentrations interferon (IFN)-γ, IFN gamma-induced protein 10 (IP-10 or CXCL10), CCL11, interleukin (IL) 1β, IL-4, IL-5, IL-6, CXCL8, IL-10,...
The prevalence of asthma in girls increases after puberty. Previous studies have detected associations between sex hormones and asthma, as well T helper 2 (Th2) asthma-typical immune responses. Therefore, we hypothesized that exogenous or endogenous hormone exposure (represented by oral contraceptive pill (OCP) use early menarche, respectively) are associated with DNA methylation (DNA-M) the Th2 transcription factor gene, GATA3, turn affecting risk girls, possibly interaction genetic...
Infant feeding may consist of direct breastfeeding (DBF), pumping and bottle (P&F), formula (FF), solid food (SFF), any combination. An accurate evaluation infant requires descriptions different patterns, consistency, transition over time.In United States America, the Feeding Practice Study II collected information on mode nine occasions in 12 months. We focused first 6 months with six occasions. To determine longitudinal patterns latent class analyses was applied assessed probabilities...
Abstract Background The role of infant feeding for food allergy in children is unclear and studies have not addressed simultaneous exposures to different foods. goal this study was analyze existing data on practices that represent realistic exposure assess the risk symptoms children. Methods Infant Feeding Practices Study II conducted by CDC US-FDA enrolled pregnant women collected information using nine repeated surveys. Participants were re-contacted after 6 years. Food at 4, 9, 12, 72...
A Gram-negative, short rod to oval-shaped bacterium (strain MW2a(T)) was isolated from the surface of leaves black mangrove Avicennia germinans and subjected a polyphasic taxonomic study. Strain MW2a(T) moderately halophilic, growing at NaCl concentrations in range 0-25 % (w/v) with optimum growth 5 NaCl. Growth occurred 12-40 degrees C (optimum, 30-35 C) pH 5.0-9.0 7.0-8.0). strictly aerobic. Phylogenetic analysis based on 16S rRNA gene showed that strain belongs genus Halomonas. The...
The relationship between fatty acids (FAs) in breast milk and the risk of childhood allergies is controversial. We prospectively investigated FAs colostrum asthma-like symptoms (AS) atopy infancy.Pregnant women were recruited Columbia Charleston, South Carolina. Colostrum mature samples collected. concentrations n-3 (eicosapentaenoic acid, α-linolenic docosapentaenoic docosahexaenoic acid) n-6 (linoleic arachidonic eicosadienoic determined by gas chromatography. AS ascertained at 6 12 months...
Modes of infant feeding such as direct and indirect breastfeeding, formula feeding, their combinations may play a role in child health.The aim was to investigate which patterns the first 6 months pose risks eczema/skin allergy children up years compared breastfeeding for at least 3 months.The Infant Feeding Practices Study II United States its 6-year follow-up provided data on modes infancy doctor's diagnosed life (1387 infants), based parental reports. Different were identified. Log-linear...