A5084455495- Animal Behavior and Welfare Studies
- Zebrafish Biomedical Research Applications
- Bat Biology and Ecology Studies
- Single-cell and spatial transcriptomics
- Organ Transplantation Techniques and Outcomes
- Stress Responses and Cortisol
- Gene Regulatory Network Analysis
- Neuroendocrine regulation and behavior
- Mental Health Research Topics
- Clostridium difficile and Clostridium perfringens research
- Neural dynamics and brain function
- Gut microbiota and health
- COVID-19 epidemiological studies
- Gastrointestinal motility and disorders
- Olfactory and Sensory Function Studies
- COVID-19 Clinical Research Studies
- Virus-based gene therapy research
- SARS-CoV-2 and COVID-19 Research
- Xenotransplantation and immune response
- Cell Image Analysis Techniques
Center for Biologics Evaluation and Research
2020-2024
United States Food and Drug Administration
2016-2024
University of Alabama at Birmingham
2017
Science Applications International Corporation (United States)
2013-2014
A critical question in understanding the immunity to SARS-COV-2 is whether recovered patients are protected against re-challenge and transmission upon second exposure. We developed a Syrian hamster model which intranasal inoculation of just 100 TCID 50 virus caused viral pneumonia. Aged hamsters more severe disease even succumbed SARS-CoV-2 infection, representing first lethal using genetically unmodified laboratory animals. After initial clearance, were re-challenged with 10 5 displayed...
Abstract Video monitoring of mice in the home-cage reveals behavior profiles without disruptions caused by specialized test setups and makes it possible to quantify changes patterns continually over long time frames. Several commercial systems are available with varying costs capabilities; however there currently no open-source for monitoring. We present an system top-down video research a slightly modified home-cage. The is designed integration Allentown NexGen ventilated racks allows...
The particularly unique composition of the gut microbiota has potential to influence health or disease status animal and human hosts. Altering homeostasis host-bacteria could lead changes in flora that result activation a specific immunological response, which explain variations observed patient responses current therapies. A standardized model is crucial for studying on therapeutic modalities. step by mouse sterility management system compares control strain C57BL/6 mice established...