A5103236214- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Personality Disorders and Psychopathology
- Neural and Behavioral Psychology Studies
- Psychopathy, Forensic Psychiatry, Sexual Offending
- Memory and Neural Mechanisms
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Psychiatric care and mental health services
- Neuroscience and Neuropharmacology Research
- Action Observation and Synchronization
- Psychosomatic Disorders and Their Treatments
- Face Recognition and Perception
- Advanced MRI Techniques and Applications
- Healthcare Decision-Making and Restraints
- Hemispheric Asymmetry in Neuroscience
- Multiple Sclerosis Research Studies
- Mental Health Research Topics
- Neurotransmitter Receptor Influence on Behavior
- Phosphodiesterase function and regulation
- Mental Health Treatment and Access
- Stalking, Cyberstalking, and Harassment
- Neuroblastoma Research and Treatments
- Psychotherapy Techniques and Applications
- Neurosurgical Procedures and Complications
- Renin-Angiotensin System Studies
Centro San Giovanni di Dio Fatebenefratelli
2025
Istituti di Ricovero e Cura a Carattere Scientifico
2025
Ospedale San Paolo
2023
ASL Roma
2020-2022
Azienda Sanitaria Locale Roma 3
2021
University of Bari Aldo Moro
2004-2019
Istituto Psicoanalitico per le Ricerche Sociali
2010-2013
University of Pennsylvania
2012
University of Calabria
2012
Sapienza University of Rome
2012
Deficits in working memory and prefrontal cortical physiology are important outcome measures schizophrenia, both have been associated with dopamine dysregulation a functional polymorphism (Val(108/158)Met) the catechol O-methyltransferase (COMT) gene that affects inactivation cortex. The purpose of present study was to evaluate patients schizophrenia effect COMT genotype on symptom variation, performance, response treatment an atypical antipsychotic drug.Thirty acute untreated were...
Functional polymorphisms in the catechol-O-methyltransferase (COMT) and dopamine transporter (DAT) genes modulate inactivation, which is crucial for determining neuronal signal-to-noise ratios prefrontal cortex during working memory. We show that COMT Met158 allele DAT 3' variable number of tandem repeat 10-repeat are independently associated healthy humans with more focused activity (as measured blood oxygen level-dependent functional magnetic resonance imaging) memory cortical network,...
A common nonsynonymous single nucleotide polymorphism leading to a serine-to-cysteine substitution at amino acid 704 (Ser(704)Cys) in the DISC1 protein sequence has been recently associated with schizophrenia and specific hippocampal abnormalities. Here, we used multimodal neuroimaging investigate large sample of healthy subjects putative association Ser(704)Cys vivo brain phenotypes including formation (HF) gray matter volume function (as assessed functional MRI) as well HF coupling neural...
Neuroblastoma is an often fatal pediatric cancer more frequent in European-American than African-American children. children, however, are at higher risk for the severe form of neuroblastoma and have worse overall survival Genome-wide association studies (GWAS) identified several single-nucleotide polymorphisms (SNP) associated to children European descent. Knowledge their still lacking.We genotyped imputed SNPs located three gene regions reported be descent, tested them 390 patients with...
Schizophrenia Spectrum Disorders (SSD) display notable sex differences: males have an earlier onset and more severe negative symptoms, while females exhibit affective better verbal abilities, a favourable prognosis. Despite extensive research, areas such as time perception positivity remain underexplored, machine learning has not yet been adequately utilised. This study aims to address these gaps by examining differences in sample of Italian patients with SSD using data-driven approach. As...
Abstract Background Recovery and human rights promotion for people with Schizophrenia Spectrum Disorders (SSDs) is fundamental to provide good care in Residential Facilities (RFs). However, there a concern about rehabilitation ethos RFs. This study aimed investigate the quality of Italian RFs, life (QoL) experience residents SSD. Methods Fourty-eight RFs were assessed using assessment tool (QuIRC-SA) 161 SSD enrolled. Seventeen provided high intensity (SRP1), 15 medium (SRP2), 16 medium-low...
There are limited data on the relationship between normal cerebrospinal fluid (CSF) opening pressure and bilateral transverse sinus stenosis (BTSS); there also several conflicting reports about upper limit of CSF pressure. To evaluate influence BTSS pressure, we prospectively recorded lumbar pressures in 217 adult patients with neurological symptoms who underwent cerebral magnetic resonance venography (MRV). The ranged 65 286 mmH(2)O (mean = 149.3, s.d. 47.5). both appearance sinuses...
Individual variability in emotion processing may be associated with genetic variation as well psychological predispositions such dispositional affect styles. Our previous fMRI study demonstrated that amygdala reactivity was independently predicted by affective-cognitive styles (phobic prone or eating disorders prone) and genotype of the serotonin transporter a discrimination task fearful facial expressions. Since insula is subjective evaluation bodily states involved human feelings, we...
Several studies investigated the neural and functional mechanisms underlying action observation in contexts with objects. However, actions seen everyday life are often embedded emotional contexts. The systems integrating emotion cues still poorly understood. Previous findings suggest that processing of both information recruits motor control areas within cerebello-thalamo-cortical pathways. It is therefore hard to determine whether social influence via a direct modulation representations...
Previous studies have reported abnormal prefrontal and cingulate activity during attentional control processing in schizophrenia. However, it is not clear how variation load modulates within these brain regions this disorder. The aim of study schizophrenia to investigate the impact increasing levels on activity. Blood oxygen level-dependent (BOLD) responses 16 outpatients with were compared those 21 healthy subjects while performing a task eliciting event-related functional magnetic...
Schizophrenia poses a significant economic burden on the healthcare system as well it has impact society at large. Reasons for such high of schizophrenia include frequent relapses and hospitalizations occurring in this disorder. We analyze effectiveness long-acting injectable antipsychotics (LAIs) compared to oral medications, terms "clinical process management" sample patients with diagnosis spectrum disorder treated community mental health centers. An observational, retrospective,...
This study aims to evaluate the acceptability of Cinematic VR technology as a novel therapeutic approach supporting Social Skills Training (SST) rehabilitation interventions among patients with schizophrenia.