A5003720826- Neurological disorders and treatments
- Pain Management and Treatment
- Musculoskeletal pain and rehabilitation
- Transcranial Magnetic Stimulation Studies
- Neurosurgical Procedures and Complications
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Spine and Intervertebral Disc Pathology
- Cerebral Venous Sinus Thrombosis
- Myofascial pain diagnosis and treatment
- Migraine and Headache Studies
- Intracerebral and Subarachnoid Hemorrhage Research
- EEG and Brain-Computer Interfaces
- Head and Neck Surgical Oncology
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pelvic floor disorders treatments
- Neuroscience and Neural Engineering
- Trigeminal Neuralgia and Treatments
- Spinal Dysraphism and Malformations
- Botulinum Toxin and Related Neurological Disorders
- Epilepsy research and treatment
- Intracranial Aneurysms: Treatment and Complications
- Traumatic Brain Injury and Neurovascular Disturbances
- Urinary Bladder and Prostate Research
Magna Graecia University
2014-2024
Azienda Ospedaliero Universitario Mater Domini
2020-2024
Ospedali Riuniti di Ancona
2024
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino
2024
Ospedale “M. Bufalini” di Cesena
2024
Ospedali Riuniti Marche Nord
2024
Agostino Gemelli University Polyclinic
2024
Istituto Neurologico Mediterraneo
2024
Ospedale San Giovanni Bosco
2024
University Hospital of Lausanne
2019
Intraoperative neurophysiological monitoring (IONM) is a crucial advancement in neurosurgery, enhancing procedural safety and precision. This technique involves continuous real-time assessment of signals, aiding surgeons timely interventions to protect neural structures. In addition inherent limitations, IONM necessitates detailed anesthetic plan for accurate signal recording. Given the growing importance we conducted narrative review including most relevant studies about modalities their...
<b>Background: </b> Bilateral transverse sinus (TS) stenosis has been found in more than 90% of patients with idiopathic intracranial hypertension (IIH). <b>Objective: To evaluate whether TS changed after normalization CSF pressure IIH during medical treatment. <b>Methods: Fourteen consecutive bilateral on cerebral MR venography (MRV) the treatment were studied. Patients followed for over a 6-year period. During follow-up, underwent repeated lumbar punctures (LPs) and MRV. MRV was always...
ObjectiveTo assess the cost-effectiveness and cost-utility of Spinal Cord Stimulation (SCS) in patients with failed back surgery syndrome (FBSS) refractory to conventional medical management (CMM).Materials MethodsWe conducted an observational, multicenter, longitudinal ambispective study, where predominant leg pain CMM expecting receive SCS+CMM were recruited 9 Italian centers followed up 24 months after SCS. We collected data on clinical status (pain intensity, disability), Health-Related...
Purpose: To determine the best predictor of lesion volume induced by magnetic resonance (MR)-guided focused ultrasound (MRgFUS) thalamotomy in patients with tremor-dominant symptoms Parkinson’s disease (PD) and essential tremor (ET) patients. Methods: Thirty-six neurological medication-refractory (n°19 PD; n°17 ET) were treated using a commercial MRgFUS brain system (Exablate Neuro 4000, Insightec) integrated 1.5 T MRI unit (Sigma HDxt; GE Medical System). Linear regression analysis was used...
Abstract Chronic pain, a complex and debilitating condition, poses significant challenge to both patients healthcare providers worldwide. Conventional pharmacological interventions often prove inadequate in delivering satisfactory relief while carrying the risks of addiction adverse reactions. In recent years, electric neuromodulation emerged as promising alternative chronic pain management. This method entails precise administration electrical stimulation specific nerves or regions within...
The headache profile of patients with idiopathic intracranial hypertension without papilledema (IIHWOP) may be indistinguishable from that migraine. Bilateral transverse sinus stenosis (BTSS) has been found in the majority IIHWOP. frequency BTSS associated IIHWOP migraine is unknown.To detect adult and to investigate whether presence identifies IIHWOP.In a prospective study December 2000 November 2005, 724 consecutive recurrent headaches who fulfilled International Headache Society...
Introduction: Bilateral transverse sinus stenosis (BTSS) has been reported to be associated with idiopathic intracranial hypertension without papilloedema in headache sufferers. Subjects and methods: To test the accuracy of short-term cerebrospinal fluid (CSF) pressure monitoring through a lumbar needle for detection elevated sufferers BTSS, we prospectively performed puncture order measure CSF opening pressures monitor, 1 h, 48 consecutive BTSS 50 normal appearance sinuses or one sinus....
There is evidence that patients with chronic daily headache (CDH) may have isolated intracranial hypertension without papilledema (IHWOP). Recent studies emphasized IH be due to cerebral venous thrombosis (CVT).To detect the occurrence of CVT in CDH.The authors investigated 114 consecutive CDH by using MR venography (MRV). A portion these underwent a lumbar puncture (LP) measure CSF pressure. MRV and LP were also performed 28 age-matched control subjects.In all subjects, both pressure...
The pathophysiology of pituitary-associated headache is unknown, although structural and functional features the tumour are proposed mechanisms. objective this study was to evaluate whether in a population with pituitary micro-adenomas related hyperprolactinemia. We recruited 29 patients microprolactinoma headache: 16 migraine (group A) 13 tension-type-headache B). prolactin (PRL) levels measured during attacks were significantly higher nine (56%) group A one patient (8%) B. In four A, PRL...
There are limited data on the relationship between normal cerebrospinal fluid (CSF) opening pressure and bilateral transverse sinus stenosis (BTSS); there also several conflicting reports about upper limit of CSF pressure. To evaluate influence BTSS pressure, we prospectively recorded lumbar pressures in 217 adult patients with neurological symptoms who underwent cerebral magnetic resonance venography (MRV). The ranged 65 286 mmH(2)O (mean = 149.3, s.d. 47.5). both appearance sinuses...
Failed back surgery syndrome (FBSS) represents one main cause of chronic neuropathic or mixed pain, functional disability and reduced Health Related Quality Life (HRQoL). Spinal Cord Stimulation (SCS) can be a value for money option to treat patients refractory conventional medical management (CMM). We estimated from real-world data: 1) the amount levels HRQoL target compared general population, 2) relationship between pain intensity, disability, overall HRQoL, 3) improvement patients'...
Flow artifacts or anatomic variants of venous sinuses often make MR venography (MRV) interpretation difficult. The authors investigated cerebral MRV in 111 subjects with normal CSF pressure to identify the most common flow abnormalities transverse (TS). Disturbance outflow one sinus was commonly observed 30% whereas both TS occurred 2 individuals. Subjects gaps should undergo lumbar puncture exclude increased pressure.
Obesity has been shown to increase lumbar CSF pressure in healthy subjects. The authors studied opening 18 obese, 33 overweight, and 49 nonoverweight subjects with normal MRI MR venography (MRV) of the brain. No subject had a above 200 mm H<sub>2</sub>O. does not cause abnormal MRV. Individuals higher than H<sub>2</sub>O should undergo MRV exclude cerebral venous thrombosis.
Background. Cerebral aneurysms are relatively common in adults, with a prevalence ranging between 1% and 5%. Subarachnoid hemorrhage, following aneurismal rupture, is major cause of death disability these patients. Matrix Metalloproteinases (MMPs) Neutrophil Gelatinase-Associated Lipocalin (NGAL) seem to be involved the pathogenesis clinical course aneurysms. In this study, we evaluated relationship tissue plasma levels MMP-9 NGAL patient ruptured unruptured middle cerebral artery Methods....
Secretome of primary cultures is an accessible source biological markers compared to more complex and less decipherable mixtures such as serum or plasma. The protonation state (PS) secretome reflects the metabolism cells can be used for cancer early detection. Here, we demonstrate a superhydrophobic organic electrochemical device that measures PS in drop derived from liquid biopsies. Using data sensor principal component analysis (PCA), developed algorithms able efficiently discriminate...
Technological advances in DBS hardware and software represent a significant growth area functional neurosurgery. These advancements have the potential to significantly enhance treatment outcomes expand scope of neurological disorders that can be effectively addressed through interventions. The introduction directional marks new phase neuromodulation, offering extended benefits for patients with Parkinson&#039;s disease, more efficient optimization clinical outcomes, targeted refractory...
Circulating Tumor Cells (CTCs) are promising biomarkers for monitoring solid cancer and were used to monitor brain tumors. Here we report two cases in which, the first time, CTCs cytological diagnostic evaluation discriminate a space-occupying lesion of brain. Two focal intracranial lesions, unclassified diagnosis, untreated apparently symptomatic, examined after high-contrast resolution Magnetic Resonance Imaging and/or Computed Tomography scans. seeded on chamber slides short-time expanded...
Previous studies suggest the expression of UbcH10 gene, that codes for a protein belonging to ubiquitin-conjugating enzyme family, as valid indicator proliferative and aggressive status tumors different origin. Therefore, look possible tools be used diagnostic markers in astrocytic neoplasias, we investigated normal brain, gliosis low-grade high-grade by immunohistochemistry. was observed astrocytoma glioblastoma. Our data indicate clear correlation between histological grade tumors....
Motor Cortex Stimulation (MCS) is less efficacious than Deep Brain (DBS) in Parkinson's disease. However, it might be proposed to patients excluded from DBS or unresponsive DBS. Ten with advanced PD underwent unilateral MCS contralaterally the worst clinical side. A plate electrode was positioned over motor cortex epidural space through single burr hole after identification of area neuronavigation and neurophysiological tests. Clinical assessment performed by total UPDRS, UPDRS III total,...