A5007070312- Orbital Angular Momentum in Optics
- Microfluidic and Bio-sensing Technologies
- Photoreceptor and optogenetics research
- Genetics, Aging, and Longevity in Model Organisms
- Microfluidic and Capillary Electrophoresis Applications
- Optical Coherence Tomography Applications
- Neuroscience and Neural Engineering
- Laser Material Processing Techniques
- Advanced biosensing and bioanalysis techniques
- Advanced Memory and Neural Computing
- Analytical Chemistry and Sensors
- Gold and Silver Nanoparticles Synthesis and Applications
- Plasmonic and Surface Plasmon Research
- Near-Field Optical Microscopy
- Spaceflight effects on biology
- Circadian rhythm and melatonin
- Advanced Fluorescence Microscopy Techniques
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Nanopore and Nanochannel Transport Studies
- Retinal and Macular Surgery
- Photonic and Optical Devices
- Random lasers and scattering media
- Plant and Biological Electrophysiology Studies
- Photochromic and Fluorescence Chemistry
Medical University of Vienna
2018-2023
Christian Doppler Laboratory for Thermoelectricity
2022
Italian Institute of Technology
2013-2016
Clemson University
2016
Seoul National University
2016
National Institute of Advanced Industrial Science and Technology
2016
Colorado State University
2016
University of Portsmouth
2016
Universidad del Noreste
2016
North Carolina State University
2016
Optofluidic microsystems are key components towards lab-on-a-chip devices for manipulation and analysis of biological specimens. In particular, the integration optical tweezers (OT) in these allows stable sample trapping, while making available mechanical, chemical spectroscopic analyses.
We report on the fabrication by a femtosecond laser of an optofluidic device for optical trapping and stretching single cells.Versatility three-dimensional capabilities this technology provide straightforward extremely accurate alignment between fluidic components.Optical red blood cells are demonstrated, thus proving effectiveness proposed as monolithic stretcher.Our results pave way new class devices cell analysis, in which, taking advantage flexibility micromachining, it is possible to...
The authors present the design and optimization of an optofluidic monolithic chip, able to provide optical trapping controlled stretching single cells. chip is fabricated in a fused silica glass substrate by femtosecond laser micromachining which can produce both waveguides microfluidic channels with great accuracy. A new fabrication procedure adopted this work allows demonstration microchannels square cross-section, thus guaranteeing improved quality trapped cell images. Femtosecond emerges...
The use of individual multimode optical fibers in endoscopy applications has the potential to provide highly miniaturized and noninvasive probes for microscopy micromanipulation. A few different strategies have been proposed recently, but they all suffer from intrinsically low resolution related numerical aperture fibers. Here, we show that two-photon polymerization allows direct fabrication micro-optics components on fiber end, resulting an increase a value is close 1. Coupling light into...
Swept-source optical coherence tomography (SS-OCT) demonstrates superior performance in comparison to spectral domain OCT with regard depth ranging. The main driver of cost for SS-OCT systems is, however, the price source. Here we show a low-cost alternative swept source that uses thermally tuned vertical-cavity surface-emitting laser (VCSEL) at 850 nm. Its center wavelength can be by adjusting operating temperature through modulation injection current. At 2 kHz sweep rate, range system was...
The chemical environment of cells is an extremely complex and multifaceted system that includes many types proteins, lipids, nucleic acids various other components. With the final aim studying these components in detail, we have developed multiband plasmonic antennas, which are suitable for highly sensitive surface enhanced Raman spectroscopy (SERS) activated by a wide range excitation wavelengths. three-dimensional hollow nanoantennas were produced on optical resist secondary electron...
Secretome of primary cultures is an accessible source biological markers compared to more complex and less decipherable mixtures such as serum or plasma. The protonation state (PS) secretome reflects the metabolism cells can be used for cancer early detection. Here, we demonstrate a superhydrophobic organic electrochemical device that measures PS in drop derived from liquid biopsies. Using data sensor principal component analysis (PCA), developed algorithms able efficiently discriminate...
Abstract PEDOT:PSS is a conductive polymer that can be integrated into last generation Organic Electrochemical Transistor (OECT) devices for biological inspection, identification and analysis. While variety of reports in literature demonstrated the chemical sensitivity these devices, still their ability resolving complex mixtures remains controversial. Similar OECT display good time dynamics behavior but lack spatial resolution. In this work, we with patterns super-hydrophobic pillars which...
Numerical tools for the evaluation of optical forces exerted by non-focused Gaussian beams are becoming increasingly important design integrated devices dedicated to cell manipulation without physical contact. Here we consider two methods based on a ray-optics approach and compare them with experimental results. We show that can be calculated good accuracy also within Rayleigh range beam wide particle sizes.
Biological neural systems are powerful, robust and highly adaptive computational entities that outperformconventional computers in almost all aspects of sensory-motor integration. Despite dramatic progress ininformation technology, there is a big performance discrepancy between artificial systemsand brains seemingly simple orientation navigation tasks. In fact, no system exists can faithfullyreproduce the rich behavioural repertoire tiny worm Caenorhabditis elegans which features one...
A low-cost swept-source optical coherence tomograph was developed using a pulsed current-driven vertical- cavity surface-emitting laser. We present the first in-vivo results ranging from cornea, across crystalline lens, to retina.
Optical tweezers are unique tools for manipulation and analysis of single cells. The development miniaturised trapping systems is a key issue as they could reduce system complexity improve usability. In addition traps can be easily combined with microfluidic circuits open the way to in-vivo applications. Ref. [1], based on an optical fiber bundle were proposed, where equivalent effect high NA focusing was obtained by total-internal-reflection (TIR) at interface between fibers...
Our current understanding of brain function is still too limited to take advantage the computational power even simplest biological nervous systems. To fill this gap, <i>Si elegans </i>project (www.si-elegans.eu) aims at developing a framework that will replicate system and rich behavior nematode <i>Caenorhabditis elegans</i>, tiny worm with just 302 neurons. One key element emulation testbed an electro-optical, micromirrorbased connectome. Unlike any other ICT communication protocol, we...