A5054208953- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Wound Healing and Treatments
- Peripheral Artery Disease Management
- Central Venous Catheters and Hemodialysis
- Pressure Ulcer Prevention and Management
- Diabetic Foot Ulcer Assessment and Management
- Pituitary Gland Disorders and Treatments
- Cardiac tumors and thrombi
- Vascular Procedures and Complications
- Adrenal and Paraganglionic Tumors
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Blood Coagulation and Thrombosis Mechanisms
- Aortic aneurysm repair treatments
- Reconstructive Surgery and Microvascular Techniques
- Cerebrovascular and Carotid Artery Diseases
- Vasculitis and related conditions
- Protease and Inhibitor Mechanisms
- Breast Cancer Treatment Studies
- Sleep and related disorders
- Machine Learning in Healthcare
- Sleep and Work-Related Fatigue
- Workplace Violence and Bullying
- Male Breast Health Studies
- Acute Kidney Injury Research
Provincia Autonoma di Trento
2020-2021
Ospedale Sant'Anna
2015-2017
Magna Graecia University
2011-2016
Abstract Venous ulcers are related to dysfunctions in extracellular matrix. Both matrix metalloproteinases ( MMP ) and neutrophil gelatinase‐associated lipocalin NGAL could play a role the healing process patients with chronic venous ulcers. We evaluated of ‐9 ulceration. performed an open‐label, parallel groups, single clinical center study. Patients leg represented test group (Group I ), whereas without control II ). In Group plasma wound fluid samples were collected at time admission,...
Abstract Chronic venous ulceration ( CVU ) of the lower limbs is a common condition affecting 1% adult population in Western countries, which burdened with high complication rate and marked reduction quality life often due to prolonged healing time. Several metalloproteinases MMPs such as MMP ‐9 together neutrophil gelatinase‐associated lipocalin NGAL appear be involved onset phases ulcer, but it still unclear how many biochemical components are responsible for time those ulcers. In this...
Abstract Chronic venous ulcer ( CVU ) represents a dreaded complication of chronic disease CVD ). The onset infection may further delay the already precarious healing process in such lesions. Some evidences have shown that matrix metalloproteinases MMPs are involved and play central role both CVUs infectious diseases. Two groups patients were enrolled to evaluate expression infected ulcers levels inflammatory cytokines as well their prevalence. Group I comprised 63 (36 females 27 males with...
Abstract Venous ulcers are common, with an overall prevalence of up to 2% in the general population western countries, and have significant socioeconomic impact. Matrix metalloproteinases ( MMP s) involved alteration extracellular matrix that could lead venous ulceration. Sixty‐four patients were recruited a 22‐month period. All subjected most appropriate treatment considering also patient's wishes (compression therapy followed or not by vein surgery). Patients randomised into two groups 32...
Background: Mixed venous and arterial ulcers account for approximately 15%–30% of all leg ulcerations. Several studies have shown that matrix metalloproteinases (MMPs) neutrophil gelatinase-associated lipocalin (NGAL) play a central role in the pathophysiology diseases. Some efficacy glycosaminoglycans, such as sulodexide (SDX), treating patients with ulcers. The aim this study was to evaluate clinical effects SDX its correlation MMPs NGAL expression mixed Methods: Patients eligible were...
Abstract Diabetic patients are at high risk of foot ulcerations that may lead to limb amputations with important socio‐economic impact. Peripheral vascular disease be frequently associated in diabetes mellitus type II its main symptom, intermittent claudication. Many studies reported the known efficacy cilostazol treating Metalloproteinase‐9 (MMP‐9) seems a biochemical marker implicated chronic wounds and particular diabetic ulcers. Cilostazol appears have lowering effect on MMP‐9 levels...
Abstract Critically ill patients are at high risk of developing pressure ulcers (PUs) and who develop PUs remain significantly longer in the intensive care unit (ICU) with increased morbidity mortality. Therefore, identification truly is important. The aim this study was to examine association low serum albumin present admission ICU onset PUs. We conducted a retrospective cohort on 610 were admitted unit. Level other biochemical indices, recorded time admission, collected. collected...
Pathophysiological events involved in the onset of chronic venous ulceration (CVU) are inflammation, activation polymorphonucleates (PMNs) and secretion proteases such as matrix metalloproteinases (MMPs), which degrade extracellular (ECM) that is a support for vascular tissutal wall. MMPs, neutrophil gelatinase-associated lipocalin (NGAL) inflammatory cytokines overexpressed CVUs they could play central role pathophysiological mechanisms skin lesion delayed wound healing. Bioflavonoids,...
Abstract Transmetatarsal amputation ( TMA ) represents an effective surgical procedure used to treat several clinical conditions such as forefoot infection, gangrene and chronic ulceration in diabetic patients. permits walking without the need for prosthesis, but nevertheless is burdened with a high complications rate. The aim of this study was evaluate possibility use platelet gel PG adjuvant therapy when performing In 6‐year period, 26 patients had undergone followed by autologous...
Abstract Chronic venous disease ( CVD ) and its most frightening complication, chronic ulceration CVU ), represent an important socioeconomic burden in the western world. Metalloproteinases have been identified pathogenesis of several vascular diseases such as problems. The aim this study was to evaluate a broad range metalloproteinases, matrix metalloproteinases MMPs ADAMs (a disintegrin metalloproteinases) ADAMTSs with thrombospondin motifs) their inhibitors, tissue inhibitor TIMPs related...
To explore the effect of sequential treatment with glucocorticoid and tumor necrosis factor-alpha inhibitors in patients Takayasu arteritis (TA).In five TA, effects prednisone for 5-7 months then adalimumab (ADA) + methotrexate (MTX) or infliximab MTX, ADA only, 12 on both clinical laboratory findings were evaluated.All treatments improved symptoms parameters without development side-effects.It was hypothesized that MMP-9 neutrophil gelatinase-associated lipocalin could be markers response...
Abstract Chronic venous ulceration ( CVU ) is the major cause of chronic wounds lower extremities, and a part complex disease. Previous studies have hypothesised that several thrombophilic factors, such as hyperhomocysteinaemia HHcy ), may be associated with ulcers. In this study, we evaluated prevalence in patients leg ulcers effect folic acid therapy on wound healing. Eighty‐seven were enrolled study to calculate population. All underwent basic treatment for ulcer (compression ± surgical...
ABSTRACT Venous ulcers are common, especially in the elderly, accounting for more than 50% of all lower extremity with important socioeconomic problems. Improving extracellular matrix functioning, by heparin administration, seems to be a way support wound healing. A total 284 patients venous were recruited 4‐year period. All subjected most appropriate treatment after considering their preference (compression therapy followed or not vein surgery). Patients randomised into two groups 142...
Abstract Post‐thrombotic syndrome ( PTS ) is a condition that can develop in about half of the patients with deep vein thrombosis DVT lower limbs. In present study, we evaluated expression inflammatory biomarkers early phases and their correlation onset . Patients were enrolled after first episode followed up for 1, 4, 8, 12 18 months. At each visit, blood sample was collected to evaluate plasma levels matrix metalloproteinase MMP )‐1,‐2,‐3,‐7,‐8 ‐9 inhibitors, TIMP ‐1,‐2, neutrophil...
Background. Cerebral aneurysms are relatively common in adults, with a prevalence ranging between 1% and 5%. Subarachnoid hemorrhage, following aneurismal rupture, is major cause of death disability these patients. Matrix Metalloproteinases (MMPs) Neutrophil Gelatinase-Associated Lipocalin (NGAL) seem to be involved the pathogenesis clinical course aneurysms. In this study, we evaluated relationship tissue plasma levels MMP-9 NGAL patient ruptured unruptured middle cerebral artery Methods....
Abstract Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns the after a period of ischaemia. Matrix metalloproteinases ( MMPs ), neutrophil gelatinase‐associated lipocalin NGAL ) and cytokines are biomarkers involved in several vascular complications. The aim this study was evaluate role , inflammatory I/R syndrome. We conducted an open label, multicentric, parallel group study, between January 2010 December 2013. Patients with acute limb ischaemia...
Abstract Peripheral vascular disease is a common complication of type 2 diabetes and often more severe diffuse than in non‐diabetic individuals with higher risk major amputations the lower limbs. Diabetic foot revascularisation using both traditional bypass surgery endovascular therapy are burdened by failure inevitable subsequent massive amputation. In this study, we examined clinical response diabetic patients critical limb ischaemia extended ischaemic wounds, treated new angiosome‐based...