A5058410722- Diagnosis and Treatment of Venous Diseases
- Venous Thromboembolism Diagnosis and Management
- Peripheral Artery Disease Management
- Wound Healing and Treatments
- Aortic aneurysm repair treatments
- Vascular Procedures and Complications
- Aortic Disease and Treatment Approaches
- Diabetic Foot Ulcer Assessment and Management
- Blood Coagulation and Thrombosis Mechanisms
- Vasculitis and related conditions
- Renal Diseases and Glomerulopathies
- Peripheral Nerve Disorders
- Intracranial Aneurysms: Treatment and Complications
- Central Venous Catheters and Hemodialysis
- Atherosclerosis and Cardiovascular Diseases
- Mesenchymal stem cell research
- Reconstructive Surgery and Microvascular Techniques
- Surgical site infection prevention
- Pituitary Gland Disorders and Treatments
- Pain Management and Treatment
- Pressure Ulcer Prevention and Management
- Adrenal and Paraganglionic Tumors
- Lymphatic Disorders and Treatments
- Pleural and Pulmonary Diseases
- Sympathectomy and Hyperhidrosis Treatments
Magna Graecia University
2014-2016
Pathophysiological events involved in the onset of chronic venous ulceration (CVU) are inflammation, activation polymorphonucleates (PMNs) and secretion proteases such as matrix metalloproteinases (MMPs), which degrade extracellular (ECM) that is a support for vascular tissutal wall. MMPs, neutrophil gelatinase-associated lipocalin (NGAL) inflammatory cytokines overexpressed CVUs they could play central role pathophysiological mechanisms skin lesion delayed wound healing. Bioflavonoids,...
Abstract Chronic venous disease ( CVD ) and its most frightening complication, chronic ulceration CVU ), represent an important socioeconomic burden in the western world. Metalloproteinases have been identified pathogenesis of several vascular diseases such as problems. The aim this study was to evaluate a broad range metalloproteinases, matrix metalloproteinases MMPs ADAMs (a disintegrin metalloproteinases) ADAMTSs with thrombospondin motifs) their inhibitors, tissue inhibitor TIMPs related...
Abstract Post‐thrombotic syndrome ( PTS ) is a condition that can develop in about half of the patients with deep vein thrombosis DVT lower limbs. In present study, we evaluated expression inflammatory biomarkers early phases and their correlation onset . Patients were enrolled after first episode followed up for 1, 4, 8, 12 18 months. At each visit, blood sample was collected to evaluate plasma levels matrix metalloproteinase MMP )‐1,‐2,‐3,‐7,‐8 ‐9 inhibitors, TIMP ‐1,‐2, neutrophil...
Abstract The aim of this study was to evaluate the results treatment venous lower limbs ulcers through topical application polynucleotides and hyaluronic acid gel ( PNHA ): Nucliaskin S™ (Mastelli srl, San Remo, Italy). This carried out in 39 consecutive patients who were randomly allocated two groups: group I (20 patients) received with (topical times a week, for total 6 weeks); II (19 only (HA) application. All surgical debridement ulcerative lesions before or HA. Pre‐treatment data...
Abstract Ischaemia reperfusion (I/R) injury refers to tissue damage caused when blood supply returns the after a period of ischaemia. Matrix metalloproteinases ( MMPs ), neutrophil gelatinase‐associated lipocalin NGAL ) and cytokines are biomarkers involved in several vascular complications. The aim this study was evaluate role , inflammatory I/R syndrome. We conducted an open label, multicentric, parallel group study, between January 2010 December 2013. Patients with acute limb ischaemia...
Critical lower limb ischaemia is a diffuse pathology that could cause claudication, severe ischaemic pain and tissue loss. The common treatment includes modification of risk factors, pharmacological therapy endovascular or surgical revascularisation the to restore pulsatile flow distally. Spinal cord stimulator seen as valid alternative in patients unsuitable for after failure adjuvant presence functioning bypass with extensive loss gangrene presenting slow difficult wound healing. We report...
Abstract Vacuum‐assisted closure (VAC) therapy is a new emerging non‐invasive system in wound care, which speeds up healing by causing vacuum, improving tissue perfusion and suctioning the exudates, facilitating removal of bacteria from wound. The application sub‐atmospheric pressure on lesions seems to alter cytoskeleton cells bed, triggering cascade intracellular signals that increase rate cell division subsequent formation granulation tissue. aim this study analyse results VAC used as an...
Most blunt aortic injuries occur in the proximal descending aorta causing acute transection of this vessel. Generally, surgical repair ruptured segment is associated with high rates morbidity and mortality view endovascular treatment seems to be a valid safer alternative. Aim article review our experience approach for traumatic rupture thoracic aorta. From April 2002 November 2014, 11 patients (9 males 2 females) were referred Department diagnosis Following preoperative Computed Tomography...
Abstract Critical limb ischaemia ( CLI ) is the most advanced form of peripheral artery disease PAD and it often associated with foot gangrene, which may lead to major amputation lower limbs, also a higher risk death due fatal cardiovascular events. Matrix metalloproteinases MMPs seem be involved in atherosclerosis, . Aim this study was evaluate variations MMP serum levels patients affected by , before after surgical revascularisation through prosthetic or venous bypass. A total 29 (7...
Abstract Chronic venous insufficiency ( CVI ) is the most advanced form of chronic disease CVD ), and often associated with skin changes such as hyperpigmentation, eczema, lipodermatosclerosis ulceration that cause discomfort, pain, sleep disturbances, absenteeism in workplace, disability deteriorated quality life QoL ). The purpose this study to evaluate prevalence patients who turn Continuous Assistance Services due presence disturbing symptoms their condition. Data were evaluated by...
Abstract Hand ischaemia due to arterial steal syndrome is an infrequent, but potentially serious complication of arteriovenous fistula ( AVF ) for haemodialysis. We present a case hand caused by in 69‐year‐old haemodialysis patient, 10 months after brachiobasilic creation. The patient underwent multiple operations without resolution pain and tissue loss. implantation adjuvant cervical spinal cord stimulator allowed the obtain complete relief wound healing. Probably, diffuse microangiopathy...
Mixed arterial and venous ulcers of the lower limbs are present in around 15-30% patients with chronic (CVUs) considered difficult-to-heal wounds. The aim this study was to evaluate results treatment mixed prostaglandin E1 (PGE1) infusion. This carried out 48 consecutive patients. Patients who showed intolerability PGE1, peripheral neuropathy, blood or systemic diseases, malignancy acute wound infections necrotic tissue on bed were excluded. separated at random into two main groups: group I...
Thromboangiitis obliterans or Buerger's disease is a rare non-atherosclerotic segmental inflammatory vasculitis that most commonly involves small and medium-sized arteries, veins nerves of the extremities, generally affects young tobacco smokers. A 53-year-old man was found to have critical ischaemia his left lower limb with foot gangrene. He underwent extremely distal surgical revascularisation using great saphenous vein bypass graft. The choice very artery as run-off vessel promoted faster...
The aim of this study is to report our experience about the treatment complex sternal and thoracic wounds following cardiothoracic surgery, using vacuum-assisted closure (VAC therapy. Twelve patients presenting with (five cases) (seven that were difficult heal treated through VAC therapy after first surgical debridement. duration application ranged from 12 36 days an average hospital stay 24·6 ± 11·4 days. During a mean follow-up months, we observed complete wound healing in seven cases...
The association of an axillary artery aneurysm and abdominal aortic is extremely rare. In this study, we describe in a 69 year-old-man. We measured patient's metalloproteinases (MMPs) Neutrophil Gelatinase - Associated Lipocalin (NGAL) levels over three years period before the rupture. speculate that high serium MMPs NGAL may have prognostic role predict rupture patients with uncommon arterial aneurysms.