A5043704475- Advanced MRI Techniques and Applications
- Neurological disorders and treatments
- Advanced Neuroimaging Techniques and Applications
- Cerebral Venous Sinus Thrombosis
- Genetic Neurodegenerative Diseases
- Glioma Diagnosis and Treatment
- Parkinson's Disease Mechanisms and Treatments
- Meningioma and schwannoma management
- Fetal and Pediatric Neurological Disorders
- Botulinum Toxin and Related Neurological Disorders
- Autoimmune Neurological Disorders and Treatments
- Spatial Neglect and Hemispheric Dysfunction
- MRI in cancer diagnosis
- Trigeminal Neuralgia and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Hedgehog Signaling Pathway Studies
- Lysosomal Storage Disorders Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Glycogen Storage Diseases and Myoclonus
- Tuberous Sclerosis Complex Research
- Mast cells and histamine
- Vagus Nerve Stimulation Research
- Infectious Encephalopathies and Encephalitis
- Aortic Disease and Treatment Approaches
- Hallucinations in medical conditions
Centro Neurolesi Bonino Pulejo
2009-2024
Istituti di Ricovero e Cura a Carattere Scientifico
2018-2019
Weatherford College
2019
Committee on Publication Ethics
2018
Inform (Germany)
2018
Morpho (United States)
2016
University of Messina
2012-2016
University of Palermo
2016
The differential diagnosis between radiation necrosis, tumor recurrence and progression is crucial for the evaluation of treatment response planning. appearance treatment-induced tissue necrosis on conventional Magnetic Resonance Imaging (MRI) similar to brain it could be difficult differentiate two entities follow-up MRI examinations. Dynamic Susceptibility Contrast-enhanced (DSC) Contrast-Enhanced (DCE) are perfusion techniques that use an exogenous, intravascular, non-diffusible...
Purpose: To determine the best predictor of lesion volume induced by magnetic resonance (MR)-guided focused ultrasound (MRgFUS) thalamotomy in patients with tremor-dominant symptoms Parkinson’s disease (PD) and essential tremor (ET) patients. Methods: Thirty-six neurological medication-refractory (n°19 PD; n°17 ET) were treated using a commercial MRgFUS brain system (Exablate Neuro 4000, Insightec) integrated 1.5 T MRI unit (Sigma HDxt; GE Medical System). Linear regression analysis was used...
Background and purpose Late‐onset Pompe disease ( LOPD ) is a rare, multisystem disorder that well established to mainly impair skeletal muscle function. Systematic studies exploring brain functions in are lacking. The aim of this study was detect morphological functional alterations as neuropsychological impairment . Methods We studied 21 patients (10 male, mean age 49 ± 18.4 years) with defined diagnosis , divided into two groups: one pre‐symptomatic hyper CK emia no weakness the second...
The aim of this study was to assess differences in brain activation a large sample Vegetative State (VS) and Minimally Conscious (MCS) patients, using functional magnetic resonance imaging (fMRI).We studied 50 patients four seven months after injury. By international clinical criteria validated behavioural scales such as the Glasgow Coma Scale Clinical Unawareness Assessment Scale, were grouped into VS (n=23) MCS (n=27). All underwent fMRI examination. After 6 months, reassessed Outcome...
Objectives Alzheimer’s disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are among the leading causes of early-onset dementia. This study aimed to assess rate whole brain atrophy by comparing bvFTD AD. Methods Two patients (one man with AD, one woman bvFTD) had neuropsychological neuroimaging assessment using automated techniques for cross-sectional longitudinal measurements. Results In patient magnetic resonance imaging (MRI) showed decreased bilateral hippocampal...
Epilepsy is one of the most common neurological diseases in both adults and children. Despite improvements medical care, 20 to 30% patients are still resistant best treatment. The quality life, neurologic morbidity, even mortality significantly impacted by medically intractable epilepsy. Nowadays, conservative therapeutic approaches consist increasing medication dosage, changing a different anti-seizure drug as monotherapy, combining antiseizure drugs using an add-on strategy. However, such...
Rationale: The aromatic L-amino acid decarboxylase (AADC) deficiency (AADCD) is a rare, autosomal recessive neurometabolic disorder caused by deficit of the AADC that involved in serotonin and dopamine biosynthesis, causing as consequence, their deficits, but also lack norepinephrine epinephrine, given precursor. Patient concerns: We report case Caucasian 43-year-old woman heterozygous for p.Ser250Phe DDC, encoding with positive family history behavioral problems. Diagnoses: Since...
The cognitive dysmetria theory suggests a disconnectivity between the dorsolateral prefrontal cortex, thalami and vermis to explain pathophysiology of schizophrenia. This study investigated metabolic integrity this neurologic circuit in patients with schizophrenia using proton magnetic resonance spectroscopy (H-MRS). Twenty-two twelve control subjects were studied. Metabolites concentrations evaluated by single-voxel technique vermis. To our knowledge, is first H-MRS experience concomitant...
Background A noninvasive method to predict the grade of a meningioma would be desirable since it anticipate information about tumour nature, recurrence and improve management outcomes. The aim present study was assess ability perfusion computed tomography (PCT) technique in predicting before surgery. Data from PCT, such as cerebral blood volume (CBV) permeability surface (PS), were correlated with immunohistolopathological information. Methods Twenty-three patients diagnosis intracranial...
Abstract Introduction: Transient global amnesia (TGA) is characterized by a sudden onset of anterograde and retrograde amnesia, sometimes associated with mild subclinical neuropsychological deficits vegetative symptoms, lasting for days after the episode. Migraine history, cardiovascular risk factors, emotional stress are considered possible factors. TGA usually occurs during seventh decade life, that is, when factors concomitant pathologies have higher incidence. Case Presentation: We...
Abstract Rationale: Limbic encephalitis is a parenchymal inflammation caused by viral, bacterial, or other microbial and postinfectious agents, which usually expressed multifocal neurological signs cognitive impairment. Patient concerns: A 50-year-old female was admitted in postacute phase, at our rehabilitative Center, to undertake neuro-motor treatment for period of 4 months. Diagnoses: The patient affected limbic encephalitis. Clinical presentation revealed attention, memory executive...
Rapid maxillary expansion (RME) is an orthodontic procedure that separates the two bones at mid palatine suture level. RME commonly used in pediatric age group to reduce and/or eliminate a transverse deficiency. At our institution we followed up 11-year-old adolescent who was diagnosed with class III malocclusion and treated by combined use of appliances (i.e., Hyrax) addition protraction devices Delaire facemask). Three months after start treatment, he complained headache double vision,...
Cervical artery dissection (CAD) and Patent Foramen Ovale (PFO) are important causes of stroke in young patients. Although PFO is considered an independent risk factor for cerebral infarction adults with cryptogenic stroke, other concomitant may be necessary to cause brain injury. could a predisposing through several mechanisms including paradoxical embolism from venous source, thrombus formation atrial septum, or arrhythmias causing thromboembolism. The pathophysiology CAD poorly understood...
We describe an unusual case of a 68-year-old male affected by cerebral amyloid angiopathy and cortical blindness associated with Anton’s syndrome. In addition, our patient presented autotopagnosia, form agnosia characterized loss body spatial representation. Neuropsychological assessment evidenced cognitive impairment. Magnetic Resonance Imaging showed hemorrhagic foci in the left occipital right occipito-parietal lobe, paratrigonal white matter, post-ischemic parenchymal gliosis. The...
Our objective was to assess the role of Intrathecal Baclofen Therapy (ITB) in cortical reorganization a patient affected by multiple sclerosis (MS) undergoing physical therapy. We reported case woman MS and severe spasticity, who performed an fMRI examination, before after ITB implantation. The subject showed controlateral motor cortex activation task. After month implantation, ipsilateral although with broader extension. examination supported hypothesis central influence patients undergo...