A5068755935- Glioma Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Acute Ischemic Stroke Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Mitochondrial Function and Pathology
- HER2/EGFR in Cancer Research
- Cutaneous Melanoma Detection and Management
- Asymmetric Synthesis and Catalysis
- Synthetic Organic Chemistry Methods
- Organoselenium and organotellurium chemistry
- Advanced Glycation End Products research
- Lung Cancer Treatments and Mutations
- Ovarian cancer diagnosis and treatment
- Asymmetric Hydrogenation and Catalysis
- Circular RNAs in diseases
- Antioxidant Activity and Oxidative Stress
- Redox biology and oxidative stress
- MicroRNA in disease regulation
- Head and Neck Cancer Studies
- Spectroscopy Techniques in Biomedical and Chemical Research
- Pituitary Gland Disorders and Treatments
- Medical and Biological Ozone Research
- Glutathione Transferases and Polymorphisms
Sichuan University
2015-2022
Dalian Medical University
2016-2021
Weatherford College
2020
West China Medical Center of Sichuan University
2017-2018
West China Hospital of Sichuan University
2017
State Key Laboratory of Biotherapy
2016-2017
Lanzhou University
2009-2014
The catalytic enantioselective synthesis of all-carbon quaternary stereogenic centers in spirocyclic diketones has been achieved for the first time by an unprecedented asymmetric vinylogous alpha-ketol rearrangement which enantiocontrolled semipinacol-type 1,2-carbon migration was realized using multifunctional cinchona-modified primary amine catalysis.
The selenoprotein thioredoxin reductase (TrxR) plays a pivotal role in regulating cellular redox homeostasis and has attracted increasing attention as promising anticancer drug target. We report here that 2-(4-aminophenyl)-1,3,2-dithiarsinane (PAO-PDT, 4), potent highly selective small molecule inhibitor of TrxR, stoichiometrically binds to the C-terminal selenocysteine/cysteine pair enzyme vitro induces oxidative stress-mediated apoptosis HL-60 cells. molecular action 4 cells involves...
The concept of adaptive aromaticity, which denotes two-state aromaticity in both the lowest singlet and triplet states, stands marked contrast to traditional one-state governed by Hückel...
// Jing Zhang 1, * , Yanlin Song 2, Baoyin Shan Min He 1 Qingqing Ren Yunhui Zeng Zhiyong Liu Hao and Jianguo Xu Department of Neurosurgery, West China Hospital, Sichuan University, Chengdu 610041, PR 2 School Medicine, These authors have contributed equally to this work Correspondence to: Xu, email: jianguo_1229@126.com Keywords: D-dimer; stroke; risk factor Received: August 05, 2017 Accepted: September 20, Published: December 18, ABSTRACT The aim study was systematically evaluate the...
The purpose of our study was to assess the prognostic role early D-dimer level in patients with acute ischemic stroke (AIS).The included patients' levels have be tested within 24 hours from onset. Poor functional outcome defined as modified Rankin Scale (mRS) ≥3. endpoints recurrence on 5-day diffusion-weighted imaging, 30-day mRS ≥3, mortality and 90-day Regarding each endpoint, odds ratios (ORs) 95% confidence intervals (CIs) were calculated AIS.A total 2,479 included. results showed that...
Abstract The signal transducers and activators of transcription 3 (STAT3) signaling pathway is a common feature in many solid tumors including non‐small cell lung cancer, whereas current therapies usually fail to treat this disease majority cases. In the present study, we aimed investigate cytotoxic effect underlying mechanisms SZC017, an oleanolic acid derivative, on human cancer cells. Cell viability was significantly decreased SZC017‐treated Mechanistically, SZC017 reduced A549 by...
Diabetic cardiomyopathy (DCM) is one of the common cardiovascular complications in patients with diabetes. Accumulating evidence has demonstrated that DCM thoroughly related to mitochondrial energy impairment and increases generation reactive oxygen species (ROS). Therefore, an ongoing study developing strategies protect cardiac mitochondria from diabetic complications, especially hyperglycemia. Phosphocreatine (PCr) plays a major metabolic role muscular cells including intracellular...
The purpose of this study was to evaluate the prognostic role neutrophil lymphocyte ratio (NLR) in patients with glioma. PubMed, EMBASE, Cochrane Library and China National Knowledge Infrastructure were searched for relevant literature. patient characteristics extracted. Hazard ratios (HRs) 95% confidence intervals (CIs) pooled estimate NLR Subgroup analysis sensitivity also performed. Six studies 1,021 included. HR elevated OS glioma 1.48 (95% CI, 1.25-1.76). Among included studies, five...
The aim of this study was to evaluate the prognostic role neutrophil lymphocyte ratio (NLR) in patients with spontaneous intracerebral hemorrhage (ICH). PubMed, EMBASE, Web Knowledge, Cochrane Library and China National Knowledge Infrastructure were searched for potentially relevant literature. patient characteristics extracted. Odds ratios (ORs) 95% confidence intervals (CIs) pooled estimate NLR ICH. Poor functional outcome defined as modified Rankin Scale≥3. Four studies 1,720 included. OR...