A5050849324- Influenza Virus Research Studies
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Viral Infections and Vectors
- Animal Disease Management and Epidemiology
- Climate Change and Health Impacts
- China's Socioeconomic Reforms and Governance
- Social Capital and Networks
- Air Quality and Health Impacts
- Natural product bioactivities and synthesis
- COVID-19 Pandemic Impacts
- Cancer-related Molecular Pathways
- Cancer, Hypoxia, and Metabolism
- Amino Acid Enzymes and Metabolism
- Cancer Mechanisms and Therapy
- Sulfur Compounds in Biology
- Trauma and Emergency Care Studies
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Outbreaks Research
- Polyomavirus and related diseases
- Sleep and Wakefulness Research
- X-ray Diffraction in Crystallography
- Epigenetics and DNA Methylation
- Cancer Research and Treatments
- Traumatic Brain Injury and Neurovascular Disturbances
Shanghai Meteorological Bureau
2017-2024
Fudan University
2015-2024
China Academy of Engineering Physics
2024
Zhangqiu City People's Hospital
2021-2023
Nanjing Foreign Language School
2023
Chinese Academy of Sciences
2020-2022
Qingdao Institute of Bioenergy and Bioprocess Technology
2020-2022
Shihezi University
2022
University of Hong Kong
2014-2020
Minhang District Central Hospital
2020
BackgroundThe estimation of influenza-associated excess mortality in countries can help to improve estimates the global burden attributable influenza virus infections. We did a study estimate respiratory mainland China for 2010–11 through 2014–15 seasons.MethodsWe obtained provincial weekly surveillance data and population 161 disease points 31 provinces from Chinese Center Disease Control Prevention years 2005–15. with an annual average rate less than 0·4% between 2005 2015 or 0·3% any...
Abstract East Asia is as a principal hotspot for emerging zoonotic infections. Understanding the likely pathways their emergence and spread requires knowledge on human-human human-animal contacts, but such studies are rare. We used self-completed interviewer-completed contact diaries to quantify patterns of these contacts 965 individuals in 2017/2018 high-income densely-populated area China, Shanghai City. Interviewer-completed recorded more social (19.3 vs. 18.0) longer duration (35.0 29.1...
Anemia of inflammation is quite prevalent in hospitalized patients with poor prognosis. Concerns about the effectiveness and safety iron supplementation have arisen, driving demand for alternative therapies. Induction hepatic hepcidin, master hormone homeostasis, causes anemia under inflammatory conditions. Previous studies indicated that hydrogen sulfide (H2S), third gasotransmitter a well-known regulator inflammation, may inhibit secretion cytokines. We thus investigated effect H2S on...
Abstract We used national sentinel surveillance data in China for 2005–2016 to examine the lineage-specific epidemiology of influenza B. Influenza B viruses circulated every year with relatively lower activity than A. B/Yamagata was more frequently detected adults children.
Human influenza virus infections cause a considerable burden of morbidity and mortality worldwide each year. Understanding regional influenza-associated outpatient is crucial for formulating control strategies against viruses.
To assess the case fatality risk (CFR) of COVID-19 in mainland China, stratified by region and clinical category, estimate key time-to-event intervals.We collected individual information aggregated data on cases from publicly available official sources 29 December 2019 to 17 April 2020. We accounted for right-censoring CFR explored factors mortality. fitted Weibull, gamma, log-normal distributions using maximum-likelihood estimation.We analyzed 82 719 laboratory-confirmed reported including...
Sepsis is a leading cause of death in patients with trauma, and the risk mortality increases significantly for each hour delay treatment. A hypermetabolic baseline explosive inflammatory immune response mask clinical signs symptoms sepsis trauma patients, making early diagnosis more challenging. Machine learning-based predictive modeling has shown great promise evaluating predicting general intensive care unit (ICU) setting, but there been no prediction model specifically developed so far.To...
Abstract Background The COVID-19 epidemic originated in Wuhan City of Hubei Province December 2019 and has spread throughout China. Understanding the fast evolving epidemiology transmission dynamics outbreak beyond would provide timely information to guide intervention policy. Methods We collected individual on 8,579 laboratory-confirmed cases from official publically sources reported outside mainland China, as February 17, 2020. estimated temporal variation demographic characteristics key...
Abstract BACKGROUND An unbalance of cell proliferation and apoptosis is an important mechanism in carcinogenesis, angiogenesis also plays a crucial role tumorigenesis. Recently, survivin has been identified as member the inhibitor protein (IAP) family. Although it shown that highly expressed gliomas, associated with tumorigenesis, progression, poor prognosis yet relation expression proliferation, apoptosis, gliomas still unclear. METHODS Eighty‐three cases brain glioma were chosen...
The fifth epidemic wave of avian influenza A(H7N9) virus in China during 2016-2017 demonstrated a geographic range expansion and caused more human cases than any previous wave. factors that may explain the recent surge incidence remain unknown. We investigated effect anthropogenic, poultry, wetland variables on all waves. Poultry predictor became much important last 2 waves they were previously, supporting assumption wider H7N9 transmission chicken reservoir. show future to northern increase...
Abstract Study Objectives Increased incidence of narcolepsy was reported in children during the 2009 H1N1 pandemic following Pandemrix, a flu vaccine. A link with A(H1N1) pdm09 infections remains controversial. Using nationwide surveillance data from China (1990 to 2017), epidemiology analyzed. Methods Individual records patients were collected 15 42 hospitals across known diagnose cases. Incidence estimated assuming representativeness these hospitals. Age-specific incidence, epidemiological...
The presence of simian virus 40 (SV40) in human brain tumors remains a controversial issue. Even if SV40 does exist tumors, the questions whether it is associated with tumorigenesis and by what mechanisms are unknown.SV40 large tumor antigen (Tag) was investigated immunoprecipitation, silver staining, Western blot analysis 65 cases 8 normal tissue. Tag-p53 Tag-pRb complexes were screened immunoprecipitation 18 15 Tag positive tissues, respectively.Tag found all ependymoma 2 choroid plexus...
Background The 2009 H1N1 influenza pandemic caused offseason peaks in temperate regions but coincided with the summer epidemic of seasonal and other common respiratory viruses subtropical Hong Kong. This study was aimed to investigate impact on age-specific curves viruses. Methods Weekly laboratory-confirmed cases A (subtypes A(H1N1), A(H3N2), virus A(H1N1)pdm09), B, syncytial (RSV), adenovirus parainfluenza were obtained from 2004 2013. Age-specific than A(H1N1)pdm09 compared between...
Unlike influenza viruses, little is known about the prevalence and seasonality of other respiratory viruses because laboratory surveillance for non-influenza not well developed or supported in China resource-limited countries. We studied interference between seasonal epidemics five common that cause illnesses Hong Kong from 2014 to 2017.The weekly laboratory-confirmed positive rates each virus were analyzed 2017 describe epidemiological trends syncytial (RSV), parainfluenza (PIV),...
Sepsis is a severe and complicated syndrome that characterized by dysregulation of host inflammatory responses organ failure. Cystathionine-γ-lyase (CSE)/ hydrogen sulfide (H2S) has potential anti-inflammatory activities in variety diseases. NADPH oxidase 4 (Nox4), member the oxidases, major source reactive oxygen species (ROS) its expression increased sepsis, but function CSE-mediated remains unknown.Macrophages were either transfected with CSE, Nox4 siRNA or transduced lentiviral vector...
The 2016-17 epidemic of human infections with avian influenza A(H7N9) virus was alarming, due to the surge in reported cases across a wide geographic area and emergence highly-pathogenic viruses. Our study aimed assess whether human-to-human transmission risk has changed 5 waves since 2013.