A5115978395- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Parkinson's Disease Mechanisms and Treatments
- Vestibular and auditory disorders
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Neurological disorders and treatments
- Neurotransmitter Receptor Influence on Behavior
- Sarcoma Diagnosis and Treatment
- Neuroscience and Neural Engineering
- Botulinum Toxin and Related Neurological Disorders
- EEG and Brain-Computer Interfaces
- Neural dynamics and brain function
- Multisensory perception and integration
- Urologic and reproductive health conditions
- Neuroscience and Music Perception
- Tumors and Oncological Cases
- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Neural and Behavioral Psychology Studies
- Curcumin's Biomedical Applications
- Balance, Gait, and Falls Prevention
- Urinary Bladder and Prostate Research
- Health and Wellbeing Research
- Treatment of Major Depression
Beijing Friendship Hospital
2020-2025
Capital Medical University
2020-2025
Tongji University
2024
Gansu Provincial Hospital
2024
Tianjin haihe hospital
2023
First People's Hospital of Chongqing
2021
Air Force Medical University
2018-2019
Beijing Wuzi University
2016
Medtronic (United States)
2011
Neuromod (Ireland)
2011
Abstract Microstructural alterations in the brain networks of Parkinson’s disease (PD) patients are correlated with gait impairments. Evaluate microstructural white matter (WM) fiber bundle tracts using neurite orientation dispersion and density imaging (NODDI) technique PD versus healthy controls (HC). In this study, 24 29 HC were recruited. NODDI high-resolution 3D structural images acquired for each participant. The indicators, including intracellular index (NDI), (ODI), isotropic volume...
Background: The neuroanatomical basis of white matter fiber tracts in gait impairments individuals suffering from Parkinson’s Disease (PD) is unclear. Methods: Twenty-four living with PD and 29 Healthy Controls (HCs) were included. For each participant, two-shell High Angular Resolution Diffusion Imaging (HARDI) high-resolution 3D structural images acquired using the 3T MRI. Diffusion-weighted data preprocessing was performed orientation distribution function to trace main individuals....
Abstract Background: Gait impairment is closely related to quality of life in patients with Parkinson’s disease (PD). This study aimed explore alterations brain microstructure PD and healthy controls (HCs) identify the correlation gait ON OFF states PD, respectively. Methods: We enrolled 24 29 from Movement Disorders Program at Beijing Friendship Hospital Capital Medical University between 2019 2020. acquired magnetic resonance imaging (MRI) scans processed diffusion kurtosis (DKI) images....
Abstract Study Objectives Increased incidence of narcolepsy was reported in children during the 2009 H1N1 pandemic following Pandemrix, a flu vaccine. A link with A(H1N1) pdm09 infections remains controversial. Using nationwide surveillance data from China (1990 to 2017), epidemiology analyzed. Methods Individual records patients were collected 15 42 hospitals across known diagnose cases. Incidence estimated assuming representativeness these hospitals. Age-specific incidence, epidemiological...
This study aimed to explore brain structural and white matter microstructural reorganization in the early stage of tinnitus identify alterations that contribute its relief after 6 months sound therapy. We studied 64 patients with idiopathic tinnitus, including 29 who were categorized into an effective group (EG) 35 ineffective (IG) according 6-month follow-up improvement Tinnitus Handicap Inventory score, along 63 healthy controls (HCs). All participants underwent diffusion tensor imaging...
Curcumin exerts a protective effect on diabetic encephalopathy (DN), It is known for its potent neuroprotective, anti-inflammatory, antioxidant, and anticancer properties. However, the underlying mechanisms of curcumin's neuroprotective effects resulting from high glucose (HG)-induced injuries remain unknown. The purpose this study to identify mechanism in DN.In study, pheochromocytoma cells (PC12 cells) were pretreated with different concentrations then co-treated 48 hours, cell viability...
Parkinson's disease (PD) is a common neurodegenerative with progressive gait, cognition, and overall functional decline. Surface area changes are frequently seen aging. In diseases, the can be evident progression. The current study aimed to regional microstructural alterations using surface-based morphometry correlate gait measures of pace rhythm domains in PD patients. We hypothesize that specific surface associated impairments. analysis might provide useful tool for assessing status motor...
This study aimed to explore brain surface-based morphometry cortical thickness changes in patients with idiopathic tinnitus before and after 24 weeks of sound therapy. In this prospective observational study, we recruited 33 who had undergone therapy 26 matched healthy controls. For the two groups subjects, a 3D-BRAVO pulse sequence was acquired both at baseline 24th week. Structural image data preprocessing performed using DPABISurf toolbox. The Tinnitus Handicap Inventory (THI) score...
This paper describes the use of an electrocorticographic (ECoG) based brain machine interface (BMI) as a validation tool for chronic, embedded neural sensing device. device is designed basic science and clinical research in neurological diseases. Using BMI application allows comparison quantifiable metrics against off-the-shelf methods, its signals represent types expected disease state.
According to previous studies, many neuroanatomical alterations have been detected in patients with tinnitus. However, few studies reported on the morphological changes observed following sound therapy. To explore brain anatomical idiopathic tinnitus using voxel-based morphometry (VBM) analysis before and after effective 12 weeks The protocol was registered ClinicalTrials.gov, ID: NCT02774122. In this study, we collected data from 27 matched healthy control (HC) individuals of therapy by...
This paper describes a neuroprosthetic methodology using functional electrical stimulation (FES) to treat urinary incontinence. The neuroprosthesis is designed enable closed-loop incontinence treatment by providing dynamic support the urethra restore function. Acute in vivo evaluation of FES control system canine model has demonstrated that can significantly increase warning time and bladder capacity prevent be triggered sensation urgency contraction urge incontinence, sudden abdominal...
Brain-derived neurotrophic factor (BDNF) regulates neuronal plasticity by targeting the tyrosine kinase B receptor (TrkB) receptor, but limited researches concentrate on role of BDNF/TrkB signaling in vestibular compensation. In this study, rats with unilateral dysfunction were established labyrinthectomy (UL) and infusion siBDNF or 7, 8-Dihydroxyflavone (7,8-DHF, a TrkB agonist). The behavioral scores deficits determined rotarod test was performed after UL. BDNF levels UL western blot...
The objective of the present study was to determine whether methadone maintenance treatment (MMT) in heroin‑dependent patients affects inhibitory control, any MMT‑induced changes correlate with dose and MMT duration, these depend on psychological characteristics patients, such as depression, anxiety impulsivity. Response inhibition GO/NO‑GO test combined functional magnetic resonance imaging (fMRI) scanning data examine control 21 heroin‑addicted who had already undergone at least three...
Based on hubs of neural circuits associated with addiction and their degree centrality (DC), this study aimed to construct the addiction-related brain networks for patients diagnosed heroin dependence undertaking stable methadone maintenance treatment (MMT) further prospectively identify ones at high risk relapse cluster analysis.Sixty-two male MMT 30 matched healthy controls (HC) underwent resting-state functional MRI data acquisition. The received 26-month follow-up monthly...
The current state of neuromodulation can be cast in a classical dynamic control framework such that the nervous system is "plant", neural stimulator controller, tools to collect clinical data are sensors, and physician's judgment estimator. This characterizes types opportunities available advance neuromodulation. In particular, technology potentially address two dominant factors limiting performance system: "observability," ability observe from output measurements, "controllability," drive...
本文报道1例发生于中年男性下咽部的脂肪肉瘤（Hypopharyngeal liposarcoma）。患者，男，47岁，主因“夜间睡眠打鼾、憋气1年余伴不能平卧位睡眠1个月”就诊，完善电子喉镜检查提示下咽部新生物、喉梗阻，完善MRI提示颈深部咽旁间隙肿物，部分突入下咽部，边界清楚。行颈部开放手术完整切除肿物，病理检查提示高分化脂肪肉瘤，术后未进一步行放化疗。术后2年内定期复查，未见复发，恢复良好。.
In this study, we performed brain surface-based morphometry to evaluate changes in sulcal depth after sound therapy patients with idiopathic tinnitus. Our results showed thatsulcal was signiêcantly reduced the left medial temporal cortex (MTC) and right somatosensory motor (SMC) of tinnitus compared healthycontrols, but increased at 24 weeks therapy. Therefore, auditory sensory regions is a potential neuroimaging biomarker forevaluating treatment eìcacy patients.
In an era characterized by rapid economic growth and evolving lifestyles, college students encounter numerous challenges, encompassing academic pressures professional competition. The respiratory muscle endurance capability is important for during prolonged aerobic exercise. Therefore, it of great significance to explore effective intervention enhance the level students. This study explores transformative potential inspiratory training (IMT) improve physical functions research comprised a...
Motivation: This study aimed to explore alterations in brain surface-based morphometry sulcal depth patients with idiopathic tinnitus before and after 24 weeks of sound therapy. Goal(s): Approach: Thirty-three underwent magnetic resonance imaging scans at baseline Results: Compared HCs, those the group had significantly lower left medial temporal cortex (MTC) right somatosensory motor (SMC). Impact: The remodeling therapy is an indicator for effective
There are currently no deep learning models applying resting-state functional magnetic resonance imaging (rs-fMRI) data to distinguish patients with Parkinson's disease (PD) and healthy controls (HCs). Moreover, study has correlated objective gait parameters brain network alterations in PD. We propose BrainNetCNN + CL, a convolutional neural (CNN) joint contrastive (CL) method analysis classify PD HCs, compare their performance classical classification methods. This aimed explore more...
After the implementation of Salt Industry System Reform Program, other domestic salt enterprises will compete for market share in Beijing. With method SWOT, this paper analyzes advantages, disadvantages, opportunities and challenges Beijing Company after industry system reform, puts forward to seize transition period, make close cooperation with upstream enterprises; innovate business models, improve service level; optimize logistics links, reduce cost circulation; enrich product variety,...
This study aimed to investigate abnormal tinnitus activity by evaluating brain surface-based amplitude of low-frequency fluctuation (ALFF) changes detected resting-state functional magnetic resonance imaging (RS-fMRI) in patients with idiopathic before and after 24 weeks sound therapy. We hypothesized that therapy could gradually return cortical local function a relatively normal range. In this prospective observational study, we recruited thirty-three who had undergone 26 matched healthy...