A5100326248- Hepatocellular Carcinoma Treatment and Prognosis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Calcium signaling and nucleotide metabolism
- Autophagy in Disease and Therapy
- Animal Virus Infections Studies
- Cancer-related molecular mechanisms research
- Microbial Metabolites in Food Biotechnology
- Viral gastroenteritis research and epidemiology
- Inflammatory Biomarkers in Disease Prognosis
- Food composition and properties
- Protein Hydrolysis and Bioactive Peptides
- Cellular transport and secretion
- Phytochemical compounds biological activities
- Membrane Separation Technologies
- Sirtuins and Resveratrol in Medicine
- Intellectual Capital and Performance Analysis
- Plant Pathogens and Fungal Diseases
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Surgical Simulation and Training
- Cancer Mechanisms and Therapy
- Proteins in Food Systems
- Mycorrhizal Fungi and Plant Interactions
Shenyang Agricultural University
2025
Zhejiang University
2015-2024
Lishui University
2022-2024
Yangtze University
2024
Center of Hubei Cooperative Innovation for Emissions Trading System
2024
Wuhan Polytechnic University
2024
Zhejiang International Studies University
2023
Hainan University
2022
Hunan University of Traditional Chinese Medicine
2022
Zhejiang University of Technology
2021
Sepsis-induced cardiac apoptosis is one of the major pathogenic factors in myocardial dysfunction. As it enhances numerous proinflammatory factors, lipopolysaccharide (LPS) considered principal mediator this pathological process. However, detailed mechanisms involved are unclear. In study, we attempted to explore LPS-induced cardiomyocyte apoptosis. We found that LPS stimulation inhibited microRNA (miR)-499 expression and thereby upregulated SOX6 PDCD4 neonatal rat cardiomyocytes....
ABSTRACTThe acidic environment within lysosomes is maintained a narrow pH range (pH 4.5-5.0) optimal for digesting autophagic cargo macromolecules so that the resulting building block metabolites can be reused. This homeostasis consequence of proton influx produced by V-type H+-translocating ATPase (V-ATPase) and rapid efflux through an unidentified “leak” pathway. By performing candidate expression screening, we discovered TMEM175 gene encodes proton-activated, proton-selective channel...
is one of the leading causative agents foodborne disease outbreaks worldwide. Herein, antibiofilm effect and mechanism Mannosylerythritol Lipid-A against
Arbuscular mycorrhizal fungi (AMF) affect cadmium (Cd) accumulation and tolerance in host plants. However, the effects of AMF on Cd phytotoxicity their underlying mechanism apples remain uncharacterized. In this study, comprehensive physiological molecular responses uninoculated Rhizophagus intraradices-inoculated Malus hupehensis Rehd. rootstocks exposed to 0 or 300 μM were investigated. inoculation mitigated Cd-induced growth photosynthesis inhibition nutrient ion disorders. It also...
The long-term prognosis of patients with hepatocellular carcinoma (HCC) after surgery remains far from satisfactory, especially in microvascular invasion (MVI). This study aimed to evaluate the potential survival benefit adjuvant lenvatinib for HCC and MVI.Patients curative hepatectomy were reviewed. All divided into 2 groups according lenvatinib. Propensity score matching (PSM) analysis was used reduce selection bias make results more robust. Survival curves are shown by Kaplan-Meier (K-M)...
Poultry necrotic enteritis is an important enteric disease which might be controlled by antibiotics. However, with the excessive use of antibiotics, phenomenon drug resistance Clostridium perfringens becoming increasingly prominent. Anemoside B4 exhibits anti-inflammatory, antioxidant and immunomodulatory effects. This study was performed to estimate effect on chicken induced C. in vivo vitro. In experiment we investigated efficacy growth curve, biofilm formation, haemolytic activity,...
Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most economically important swine pathogens causes failure in sows disease growing pigs. PRRSV mainly infects porcine alveolar macrophages (PAMs), leading to subversion innate adaptive immunity The transcriptome analysis gene expression profiles PRRSV-infected PAMs essential for understanding pathogenesis PRRSV. Here we performed next-generation RNA sequencing a comprehensive bioinformatics characterize dynamic...
Soybeans possess unexpected flavors and are difficult to be absorbed by the gastrointestinal tract. Kefir grain fermentation provides diverse strains bioactive compounds, which may enhance flavor bioaccessibility. Third-generation sequencing was applied analyze microbial diversity in milk soybean kefir grains this study. In both types of grains, most common bacterial genus
SUMOylation is a reversible post-translational modification that regulates the function of target protein. In this study, we first predicted by software multiple proteins porcine reproductive and respiratory syndrome virus (PRRSV) could be sumoylated. Next, confirmed Nsp1β, Nsp4, Nsp9, Nsp10 nucleocapsid (N) protein PRRSV interact with sole SUMO E2 conjugating enzyme Ubc9, Ubc9 co-localized Nsp9 in cytoplasm, while N both cytoplasm nucleus. Finally, demonstrated sumoylated either SUMO1 or...
Abnormal lipid accumulation is associated to the development of metabolic diseases such as hepatic steatosis and storage diseases. Pharmacological agents that can attenuate therefore have therapeutic potentials for these Resveratrol (RSV), a natural active substance found in fruits nuts, has been reported effectively reduce intracellular accumulation, but underlying mechanisms RSV remain elusive. Here, we show triggers an endoplasmic reticulum (ER)- Ca2+ signaling activates transcriptional...
Abstract Background & aims Complications after laparoscopic liver resection (LLR) are important factors affecting the prognosis of patients, especially for complex hepatobiliary diseases. The present study aimed to evaluate value a three-dimensional (3D) printed dry-laboratory model in precise planning LLR Methods Patients with diseases who underwent were preoperatively enrolled, and divided into two groups according whether using 3D-printed (3D vs. control group). Clinical variables...
Endothelial progenitor cells (EPCs) are involved in the repair of vessels and angiogenesis useful treatment ischemic diseases. The dimethylarginine dimethylaminohydrolase (DDAH)/asymmetric (ADMA) pathway is regulated by silent information regulator 1 (SIRT1), leading to senescence endothelial (ECs). Here, we demonstrated that peripheral blood EPCs predominantly expressed DDAH2 increased with EPC differentiation. dysfunction were induced on interruption expression, whereas mRNA expression...
Backwashing process is critical for the normal operation of oilfield wastewater filter with walnut shell media. As media different from conventional such as sand in terms surface physicochemical properties and pollutants are drinking water or municipal waste water, investigation on backwash characteristics used filtration necessary. In this paper, performances three backwashing modes including fluidization, hydraulic swirling, blade stirring experimentally evaluated dirty an Shengli oilfeild...
Icariin is the most effective bioactive compound in Herba Epimedii. To enhance content of icariin epimedium water extract, a novel strain, Papiliotrema laurentii ZJU-L07, producing an intracellular α-L-rhamnosidase was isolated from soil and mutagenized. The specific activity 29.89 U·mg−1 through purification, molecular mass enzyme 100 kDa, as assayed by SDS-PAGE. characterization purified determined. optimal temperature pH were 55 °C 7.0, respectively. stable range 5.5–9.0 for 2 h over 80%...
Background & Aims: To examine the association of history preoperative antiviral therapy (AVT) with tumor recurrence and overall survival in HBV-related HCC patients undergoing curative-intent hepatectomy. Methods: Patients who underwent hepatectomy for between 2014 2019 at 4 Chinese hospitals were analyzed. categorized as having undergone > 1 year or without (non-AVT). Patient clinical features, short-term outcomes, (OS), time-to-recurrence (TTR) also compared. Multivariate Cox regression...
The prognosis of patients with hepatocellular carcinoma (HCC) undergoing hepatectomy is unsatisfactory, especially for those microvascular invasion (MVI). This study aimed to determine the impact adjuvant transcatheter arterial chemoembolization (TACE) and Lenvatinib on HCC MVI after hepatectomy. Patients diagnosed were reviewed, stratified into four groups according TACE and/or Lenvatinib. Multivariate Cox regression analyses are used independent risk factors. 346 included, divided (Group...
Abstract Background and aims Preoperative prediction of microvascular invasion (MVI) using a noninvasive method remain unresolved, especially in HBV-related intrahepatic cholangiocarcinoma (ICC). This study aimed to build validate preoperative model for MVI ICC. Methods Patients with HBV-associated ICC undergoing curative surgical resection were identified. Univariate multivariate logistic regression analyses performed determine the independent risk factors training cohort. Then, was built...