A5019911642- Epigenetics and DNA Methylation
- Genetic Associations and Epidemiology
- Cognitive Abilities and Testing
- Child and Adolescent Psychosocial and Emotional Development
- Genetic Syndromes and Imprinting
- Tryptophan and brain disorders
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Diet and metabolism studies
- Early Childhood Education and Development
- Genetic Mapping and Diversity in Plants and Animals
- Metabolomics and Mass Spectrometry Studies
- Health, Environment, Cognitive Aging
- Identity, Memory, and Therapy
- Cancer-related gene regulation
- RNA modifications and cancer
- Bioinformatics and Genomic Networks
- Neuroinflammation and Neurodegeneration Mechanisms
- Gene expression and cancer classification
- Bipolar Disorder and Treatment
- Genomics and Rare Diseases
- Autism Spectrum Disorder Research
- Receptor Mechanisms and Signaling
- Family Support in Illness
- Schizophrenia research and treatment
Virginia Commonwealth University
2015-2025
Edinburgh Cancer Research
2024
The University of Queensland
2023
Florey Institute of Neuroscience and Mental Health
2018
Swinburne University of Technology
2018
Center For Biomarker Research In Medicine
2008-2013
University of Richmond
2013
Virginia Commonwealth University Medical Center
2003-2012
Virginia BioTechnology Research Park
2010
Prevention Institute
2002
This article examines how parental education level moderates the genetic and environmental contributions to variation in verbal IQ. Data are from 1909 non‐Hispanic Whites African American sibling pairs National Longitudinal Study of Adolescent Health, which obtained nationally‐based samples identical (MZ) twins, fraternal (DZ) full half siblings, cousins (in same household), biologically unrelated siblings. In whole sample, variance estimate for heritability ( h 2 = .57, SE .08) was greater...
<h3>Importance</h3> Being exposed to trauma is a common childhood experience associated with symptoms and impairments in childhood. <h3>Objective</h3> To assess the association between cumulative exposure adult psychiatric functional outcomes. <h3>Design, Setting, Participants</h3> Prospective, population-based cohort study of 1420 participants. A community representative sample participants was assessed structured Child Adolescent Psychiatric Assessment interviews up 8 times (ages 9-16...
Epigenetic studies present unique opportunities to advance schizophrenia research because they can potentially account for many of its clinical features and suggest novel strategies improve disease management.To identify DNA methylation biomarkers in blood.The sample consisted 759 cases 738 controls (N = 1497) collected Sweden. We used methyl-CpG-binding domain protein-enriched genome sequencing the methylated genomic fraction, followed by next-generation sequencing. obtained a mean (SD)...
Major depressive disorder is associated with an increased risk of mortality and aging-related diseases. The authors examined whether major depression higher epigenetic aging in blood as measured by DNA methylation (DNAm) patterns, clinical characteristics have a further impact on these the findings replicate brain tissue.DNAm age was estimated using all sites 811 depressed patients 319 control subjects no lifetime psychiatric disorders low symptoms from Netherlands Study Depression Anxiety....
DNA methylation (DNAm) is one of the most reliable biomarkers aging across mammalian tissues. While age-dependent global loss DNAm has been well characterized, gain less characterized. Studies have demonstrated that CpGs which with age are enriched in Polycomb Repressive Complex 2 (PRC2) targets. However, whole-genome examination all PRC2 targets as determination pan-tissue or tissue-specific nature these associations lacking. Here, we show low-methylated regions (LMRs) highly bound by...
The central importance of epigenetics to the aging process is increasingly being recognized. Here we perform a methylome-wide association study (MWAS) in whole blood DNA from 718 individuals, aged 25-92 years (mean = 55). We sequenced methyl-CpG-enriched genomic fraction, averaging 67.3 million reads per subject, obtain methylation measurements for ∼27 autosomal CpGs human genome. Following extensive quality control, adaptively combined measures neighboring, highly-correlated into 4 344 016...
Genetic influence on DNA methylation is potentially an important mechanism affecting individual differences in humans. We use next-generation sequencing to assay blood at approximately 4.5 million loci, each comprising 2.9 CpGs average, 697 normal subjects. Methylation measures locus are tested for association with single nucleotide polymorphisms (SNPs) exhaustively screen quantitative trait loci (meQTLs). Using stringent false discovery rate control, 15 % of sites show genetic influence....
<h3>Context</h3> Neuroticism is a trait that reflects tendency toward negative mood states. It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, it accounts for much of the substantial comorbidity seen between these disorders. <h3>Objective</h3> To identify common genetic variants affect neuroticism better understand (the between) broad range disorders develop effective treatments. <h3>Design, Setting, Participants</h3> More than 420 000 markers...
Abstract Twin‐singleton differences in problem behaviours 2–3‐year‐olds were studied. Maternal ratings of children's obtained with the CBCL/2–3. The twin sample Consisted d 1863 pairs (456 MZ, 907 DZ), singletons consisted 420 children from general population. Results indicated that level twins was broadly comparable to singletons. Four seven syndromes showed lower scores for twins. These difference, however, small and mainly caused In tower DZ comparison MZ Pan difference could be...
Genetically informative data can be used to address fundamental questions concerning the measurement of behavior in children. The authors illustrate this with longitudinal multiple-rater on internalizing problems twins. Valid information a child is obtained for that multiple raters agree upon and rater-specific perception child's behavior. Rater-disagreement variance varsigma2(rd) accounted 35% individual differences Up 17% was by additive genetic varsigma2(Au). Thus, disagreement should not...
Objective Interindividual clinical response to leukotriene modifiers is highly variable, and less efficacious than inhaled corticosteroids in treating asthma. Genetic variability 5-lipoxygenase biosynthetic receptor pathway gene loci may influence cysteinyl-leukotriene production subsequent modifiers. Methods Using data from two trials of 12-week duration, post-hoc analyses were performed 174 patients randomized montelukast. Associations between polymorphisms 10 candidate genes (ALOX5,...
Background Longitudinal studies are needed to clarify whether early adversities associated with advanced methylation age or if they actually accelerate aging. This study test different dimensions of childhood adversity biological aging from adulthood, and, so, via which mechanisms. Methods 381 participants provided one blood sample in (average 15.0; SD = 2.3) and another young adulthood 23.1; 2.8). Participants their parents a median 6 assessments (total 1,950 observations), reporting...
Objective: Postpartum depression (PPD) is a common subtype of major depressive disorder (MDD) that more heritable, yet understudied in psychiatric genetics. The authors conducted meta-analyses genome-wide association studies (GWASs) to investigate the genetic architecture PPD. Method: Meta-analyses were on 18 cohorts European ancestry (17,339 PPD cases and 53,426 controls), one cohort East Asian (975 3,780 African (456 1,255 totaling 18,770 58,461 controls. Post-GWAS analyses included 1)...
Maternal ratings on internalizing (INT) and externalizing (EXT) behaviors were collected in a large, population-based longitudinal sample.The numbers of participating twin pairs at ages 3, 7, 10, 12 5,602, 5,115, 2,956, 1,481, respectively.Stability both was accounted for by genetic shared environmental influences.The contribution to stability (INT: 43%; EXT: 60%) resulted from the fact that subset genes expressed an earlier age still active next time point.A common set factors operated all...
Abstract Motivation: During the past decade, we have seen an exponential growth of vast amounts genetic data generated for complex disease studies. Currently, across a variety biological problems, there is strong trend towards integration from multiple sources. So far, candidate gene prioritization approaches been designed specific purposes, by utilizing only some available sources studies, or using simple weight scheme. Specifically to psychiatric disorders, has no approach that fully...
Abstract Motivation Enrichment-based technologies can provide measurements of DNA methylation at tens millions CpGs for thousands samples. Existing tools methylome-wide association studies cannot analyze datasets this size and lack important features like principal component analysis, combined analysis with SNP data outcome predictions that are based on all informative sites. Results We present a Bioconductor R package called RaMWAS full set large-scale studies. It is free, cross-platform,...