A5057309609- Gut microbiota and health
- Tryptophan and brain disorders
- Diet and metabolism studies
- Stress Responses and Cortisol
- Neuroendocrine regulation and behavior
- Dietary Effects on Health
- Nutritional Studies and Diet
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Birth, Development, and Health
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Neurological disorders and treatments
- Diabetes Treatment and Management
- Alzheimer's disease research and treatments
- Psychosomatic Disorders and Their Treatments
- Natural Antidiabetic Agents Studies
- Adolescent and Pediatric Healthcare
- Nutrition, Health and Food Behavior
- Global Maternal and Child Health
- Clostridium difficile and Clostridium perfringens research
- Diet, Metabolism, and Disease
- AI in cancer detection
- Pharmacological Effects and Toxicity Studies
- COVID-19 Impact on Reproduction
UNSW Sydney
2020-2024
Deakin University
2012-2021
Barwon Health
2020-2021
Objective This study aimed to explore effects of adjunctive N -acetylcysteine (NAC) treatment on inflammatory and neurogenesis markers in unipolar depression. Methods We embarked a 12-week clinical trial NAC (2000 mg/day compared with placebo) as an for A follow-up visit was conducted 4 weeks following the completion treatment. collected serum samples at baseline end phase (week 12) determine changes interleukin-6 (IL6), C-reactive protein (CRP) brain-derived neurotrophic factor (BDNF)...
The effects of diet cycling on cognition and fecal microbiota are not well understood.
Bipolar disorder is a mental health condition with progressive social and cognitive function disturbances. Most patients' treatments are based on polypharmacy, but no biological basis little known of the drugs' interactions. The aim this study was to analyze effects lithium, valproate, quetiapine, lamotrigine, interactions between them, markers inflammation, bioenergetics, mitochondrial function, oxidative stress in neuron-like cells microglial cells.Neuron-like lipopolysaccharide-stimulated...
Abstract Objective This study aimed to explore effects of adjunctive treatment with N -acetyl cysteine (NAC) on markers inflammation and neurogenesis in bipolar depression. Methods is a secondary analysis placebo-controlled randomised trial. Serum samples were collected at baseline, week 8, 32 the open-label maintenance phases clinical trial determine changes interleukin (IL)-6, IL-8, IL-10, tumour necrosis factor-α (TNF-α), C-reactive protein (CRP) brain-derived neurotrophic factor (BDNF)...
The amyloid precursor protein (APP) generates a number of peptides when processed through different cleavage mechanisms, including the beta peptide that is implicated in development Alzheimer's disease. It well established APP via its cleaved regulates aspects neuronal metabolism. Emerging evidence suggests amyloidogenic processing can lead to altered systemic metabolism, similar observed metabolic disease states. In present study, we investigated effect deficiency on obesity-induced...
This study aimed to explore effects of adjunctive minocycline treatment on inflammatory and neurogenesis markers in major depressive disorder (MDD). Serum samples were collected from a randomised, placebo-controlled 12-week clinical trial (200 mg/day, added as usual) for adults (n = 71) experiencing MDD determine changes interleukin-6 (IL-6), lipopolysaccharide binding protein (LBP) brain derived neurotrophic factor (BDNF). General Estimate Equation modelling explored moderation baseline...
Abstract Background Despite well-known effects of diet on gut microbiota diversity, relatively little is known about how maternal quality shapes the longitudinal maturation in offspring. To investigate, we fed female rats standard chow (Chow) or a western-style, high-choice cafeteria (Caf) prior to and during mating, gestation lactation. At weaning (3 weeks), male offspring were either maintained their mother’s (ChowChow, CafCaf groups) switched other (ChowCaf, CafChow). Fecal microbial...
Abstract Gut bacteria from the genus Prevotella are found in high abundance faeces of non-industrialised communities but low industrialised, Westernised communities. copri is one principal species within human gut. As it has been associated with developmental health and disease states, we sought to (i) develop a real-time polymerase chain reaction (PCR) rapidly determine P. (ii) investigate its large group Australian pregnant mothers. The Barwon Infant Study pre-birth cohort study ( n =...
Maternal obesity increases the risk of health complications in children, highlighting need for effective interventions. A rat model maternal to examine whether a diet switch intervention could reverse adverse effects an unhealthy postweaning is used.
Abstract Pregnancy can alter gut microbiota composition, but how an obesogenic diet impacts maternal microbiota, and the extent to which this influences offspring microbiome be obscured by confounding factors. This study examined changes in composition across pre-pregnancy, gestation lactation rat dams fed either a high-fat, high-sugar Cafeteria (Caf) or Chow. Microbiome development was assessed their weaned onto chow. Caf consumption during pregnancy increased weight gain adiposity,...
目的:コンピューター技術の急速な進歩に伴い画像解析技術が進み, 細胞診の自動スクリーニング装置が開発されてきている. 自動スクリーニング装置の導入目的として,「精度の向上」と「省力化」が求められる. わが国においては2000年に日本臨床細胞学会から陰性標本の10%以上のダブルチェックの必要性と署名の励行について見解が表明されたが, われわれの施設は1993年にCollege of American Pathologists (CAP) の認定を得たためCAPの精度管理基準に従っている. その精度管理基準により婦人科の陰性標本の10%以上を再検することが義務づけられている. そこでわれわれは, 1995年米国Food and Drug Administration (FDA) により認可された婦人科細胞診自動スクリーニング装置 (Auto Pap) を導入し1998年から精度管理を目的としたrescreening用としてroutineに使用し成果を上げている. さらに同装置は1998年に一次スクリーニング用として75%の再検必要率値の条件でFood に承認された....