A5048516290- Multiple Sclerosis Research Studies
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Peripheral Neuropathies and Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Immunotherapy and Immune Responses
- Gut microbiota and health
- Polyomavirus and related diseases
- Immune Response and Inflammation
- Genetic Neurodegenerative Diseases
- Advanced Neuroimaging Techniques and Applications
- IL-33, ST2, and ILC Pathways
- Sphingolipid Metabolism and Signaling
- Autoimmune and Inflammatory Disorders Research
- Systemic Lupus Erythematosus Research
- Tryptophan and brain disorders
- Metabolism and Genetic Disorders
- Galectins and Cancer Biology
- Olfactory and Sensory Function Studies
- Psoriasis: Treatment and Pathogenesis
- Infectious Encephalopathies and Encephalitis
- Neurological diseases and metabolism
- Bone Metabolism and Diseases
- Porphyrin Metabolism and Disorders
National Center of Neurology and Psychiatry
2015-2024
John Wiley & Sons (United States)
2021-2024
Hudson Institute
2021-2024
Tokyo Medical and Dental University
2024
Kyoto University
2016-2023
Kindai University
2023
National Center for Global Health and Medicine
2023
Kyoto Prefectural University of Medicine
2023
Kansai Medical University
2023
Institute of Science Tokyo
2022
The pathogenesis of multiple sclerosis (MS), an autoimmune disease affecting the brain and spinal cord, remains poorly understood. Patients with MS typically present recurrent episodes neurological dysfunctions such as blindness, paresis, sensory disturbances. Studies on experimental encephalomyelitis (EAE) animal models have led to a number testable hypotheses including hypothetical role altered gut microbiota in development MS. To investigate whether patients is altered, we compared 20...
Neuromyelitis optica (NMO) is an inflammatory disease affecting the optic nerve and spinal cord, in which autoantibodies against aquaporin 4 (AQP4) water channel protein probably play a pathogenic role. Here we show that B-cell subpopulation, exhibiting CD19 int CD27 high CD38 CD180 − phenotype, selectively increased peripheral blood of NMO patients anti-AQP4 antibodies (AQP4-Abs) are mainly produced by these cells patients. These B showed morphological as well phenotypical characteristics...
Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous system. Foxp3+ regulatory (Treg) cells are reduced in frequency and dysfunctional patients with MS, but underlying mechanisms this deficiency unclear. Here, we show that induction human IFN-γ-IL-17A-Foxp3+CD4+ inhibited presence circulating exosomes from MS. The exosomal miRNA profile MS differs healthy controls, let-7i, which markedly increased suppresses Treg by targeting insulin like growth factor 1...
Multiple sclerosis (MS), an autoimmune disease of the central nervous system, generally starts as relapsing remitting form (RRMS), but often shifts into secondary progressive MS (SPMS). SPMS represents a more advanced stage MS, characterized by accumulating disabilities and refractoriness to medications. The aim this study was clarify microbial functional differences in gut microbiomes different stages MS. Here, we compared patients with RRMS, SPMS, two closely related disorders healthy...
Abstract Development of acute experimental autoimmune encephalomyelitis (EAE) depends on Th17 cells expressing the nuclear factor NR4A2. However, in mice lacking NR4A2 T cells, a late-onset disease is still inducible, despite great reduction inflammation. We here reveal that development this late onset cytotoxic T-cell-like CD4 + T-box transcription Eomesodermin (Eomes). T-cell-specific deletion Eomes gene remarkably ameliorates EAE. Strikingly, similar are increased peripheral blood and...
Multiple sclerosis (MS), a putative autoimmune disease of the central nervous system (CNS), commonly presents as relapsing-remitting MS (RRMS), characterized by recurrent episodes peripheral disabling symptoms resulting from inflammatory CNS damage. Many RRMS patients transition to chronic course with progressive neurological dysfunctions (secondary MS, SPMS), progression rate varying between and over time. SPMS pathogenesis is now linked immune-cell-mediated processes, although mechanisms...
Abstract Recent reports have shown that IL-17-producing CD4+ T cells (Th17 cells) belong to a distinct helper cell lineage and are critically involved in the pathogenesis of autoimmune diseases allergies. However, chemokine receptor profile Th17 remains be clarified. In this study, we report human identified as CCR2+CCR5− memory cells. Analysis PBMC from healthy donors showed CCR2+ produce much larger amounts IL-17 than CCR2− cells, indicating preferential expression CCR2 on Notably,...
The mechanism underlying the progression of relapsing-remitting multiple sclerosis to secondary progressive (SPMS), characterized by accumulating fixed disability, is yet be fully understood. Although alterations in gut microbiota have recently been highlighted pathogenesis, linking altered environment with remote CNS pathology remains unclear. Here, we analyse human CD4+ memory T cells expressing gut-homing chemokine receptor CCR9 and found a reduced frequency CCR9+ peripheral blood...
Multiple sclerosis (MS) is a demyelinating disease of the CNS that presumably mediated by CD4(+) autoimmune T cells. Although both Th1 and Th17 cells have potential to cause inflammatory pathology in rodents, identity pathogenic remains unclear human MS. Given each Th cell subset preferentially expresses specific chemokine receptors, we were interested know whether defined particular receptor profile play an active role pathogenesis In this article, report CCR2(+)CCR5(+) constitute unique...
Background: Fingolimod is an oral drug approved for multiple sclerosis (MS) with ability to trap central memory T cells in secondary lymphoid tissues; however, its variable effectiveness individual patients indicates the need evaluate effects on other cells. Objective: To clarify of fingolimod B-cell populations MS. Methods: We analysed blood samples from 9 fingolimod-treated and 19 control MS by flow cytometry, determine frequencies activation states naive B cells, plasmablasts. Results:...
To characterize phenotypes of T cells that accumulated in multiple sclerosis (MS) lesions, to compare the lesional T-cell receptor (TCR) repertoire subsets peripheral blood, and identify paired α β chains from single CD8(+) an index patient who we followed for 18 years.We combined immunohistochemistry, laser microdissection, single-cell multiplex PCR subtypes TCRα TCRβ individual brain-infiltrating frozen brain sections. The TCR repertoires were analyzed by pyrosequencing.We found a Vβ1(+)...
Resident memory T (Trm) cells are a unique population that can survive and function in compartmentalized tissue with inflammatory potential. We aim to investigate the alteration of Trm acute/chronic neurodegenerative diseases CNS.The frequencies CD4+ CD8+ expressing both CD69 CD103, markers for cells, were quantified peripheral blood CSF (n = 80 44, respectively) cross-sectional manner. The transcriptional profile Trm-like was further analyzed using public single-cell dataset.The frequency...
ABSTRACT BACKGROUND AND PURPOSE Recent studies suggest that the autoantibodies against adrenergic/muscarinic receptors might be one of causes and potential markers myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The purpose this study was to investigate structural network changes related autoantibody titers in ME/CFS by performing a single‐subject gray matter similarity‐based analysis. METHODS We prospectively examined 89 consecutive right‐handed patients who underwent both...
Eomesodermin‐expressing (Eomes + ) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes Th cell frequency was increased the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by from such patients high compared with controls. A observed initial (acutely progressive) stage sclerosis, a positive correlation between cognitive decline Therefore, may be involved...
To compare effects of natalizumab on inflammatory and regulatory T cells with regard to expression α4-integrin (CD49d).Twenty-seven natalizumab-naive 8 natalizumab-treated patients multiple sclerosis (MS), 7 neuromyelitis optica (NMO) or NMO spectrum disorder, healthy controls were included. The positive rate CD49d was analyzed compared among helper 1 (Th1), 17 (Th17), (Treg) (CD49d+Th1, CD49d+Th17, CD49d+Treg, respectively).Natalizumab treatment increased ratios, CD49d+Th1/CD49d+Treg,...
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system that causes damage to myelin sheath as well axonal degeneration. Individuals with MS appear have changes in numbers and functions T-cell subsets, leading immunological imbalance accompanied by enhanced autoreactivity. In previous preclinical studies, (2 S,3 S,4R)-1-O-(α-D-Galactopyranosyl)-N-tetracosanoyl-2-amino-1,3,4-nonanetriol (OCH), a synthetic analog α-galactosylceramide stimulatory for...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by and post-exertional malaise, accompanied various signs of neurological autonomic dysfunction. ME/CFS often triggered an infectious episode associated with aberrant immune system. Here we report that disorder skewed B cell receptor gene usage. By applying next-generation sequencing to determine the clone-based IGHV/IGHD/IGHJ repertoires, revealed biased usage several IGHV genes in...
Abstract Background and Purpose Free‐water‐corrected diffusion tensor imaging (FW‐DTI), a new analysis method for MRI, can indicate neuroinflammation degeneration. There is increasing evidence of autoimmune etiology in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). We used FW‐DTI conventional DTI to investigate microstructural brain changes related autoantibody titers patients with ME/CFS. Methods prospectively examined 58 consecutive right‐handed ME/CFS who underwent both MRI...
Objectives The central nervous system disorder in systemic lupus erythematosus (SLE), called neuropsychiatric (NPSLE), is one of the most severe phenotypes with various clinical symptoms, including mood disorder, psychosis and delirium as diffuse neuropsychological manifestations (dNPSLE). Although stress aggravating factors for its role pathogenesis dNPSLE remains to be elucidated. We aimed investigate effects on pathophysiology SLE using lupus-prone mice patients’ data. Methods Sleep...
Neuromyelitis optica (NMO) is an autoimmune astrocytopathy mediated by anti-AQP4 antibody-producing B cells. Recently, a B-cell subset highly expressing CD11c and T-bet, originally identified as age-associated cells, has been shown to be involved in the pathogenesis of various diseases. The objective this study was determine relationship between frequency
Background Diffusional kurtosis imaging (DKI) and neurite orientation dispersion density (NODDI) metrics provide more specific information regarding pathological changes than diffusion tensor (DTI). Purpose To detect microstructural abnormalities in myalgic encephalomyelitis (ME) / chronic fatigue syndrome (CFS) patients by using DKI NODDI metrics. Study Type Prospective. Population Twenty ME/CFS 23 healthy controls were recruited. Field Strength/Sequence Three‐b value DWI (b‐values = 0,...