A5033339442- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- T-cell and B-cell Immunology
- Immune Response and Inflammation
- Immune Cell Function and Interaction
- Amyotrophic Lateral Sclerosis Research
- Nerve injury and regeneration
- Reproductive System and Pregnancy
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
John Wiley & Sons (United States)
2024
Hudson Institute
2024
National Center of Neurology and Psychiatry
2023-2024
Tokyo Medical and Dental University
2024
Kindai University
2023
National Center for Global Health and Medicine
2023
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system that causes damage to myelin sheath as well axonal degeneration. Individuals with MS appear have changes in numbers and functions T-cell subsets, leading immunological imbalance accompanied by enhanced autoreactivity. In previous preclinical studies, (2 S,3 S,4R)-1-O-(α-D-Galactopyranosyl)-N-tetracosanoyl-2-amino-1,3,4-nonanetriol (OCH), a synthetic analog α-galactosylceramide stimulatory for...
Eomesodermin‐expressing (Eomes + ) T‐helper (Th) cells show cytotoxic characteristics in secondary progressive multiple sclerosis. We found that Eomes Th cell frequency was increased the peripheral blood of amyotrophic lateral sclerosis and Alzheimer's disease patients. Furthermore, granzyme B production by from such patients high compared with controls. A observed initial (acutely progressive) stage sclerosis, a positive correlation between cognitive decline Therefore, may be involved...
Neuromyelitis optica (NMO) is an autoimmune astrocytopathy mediated by anti-AQP4 antibody-producing B cells. Recently, a B-cell subset highly expressing CD11c and T-bet, originally identified as age-associated cells, has been shown to be involved in the pathogenesis of various diseases. The objective this study was determine relationship between frequency
'No evidence of disease activity (NEDA)', judged by clinical and radiological findings, is a therapeutic goal in patients with multiple sclerosis (MS). It is, however, unclear if distinct biological mechanisms contribute to the maintenance NEDA. To clarify immunological background long-term stability defined NEDA, circulating immune cell subsets relapsing-remitting MS (RRMS) were analyzed using flow cytometry. Patients showing NEDA (n = 31) had significantly higher frequencies non-classical...
Neuromyelitis optica spectrum disorder (NMOSD) is a disabling autoimmune neurologic disease. Anti-IL-6 receptor (IL-6R) therapy prevents relapses in patients with anti-aquaporin 4 (AQP4)-IgG-positive NMOSD; however, it remains unclear how cellular immune components are altered by anti-IL-6R therapy. In this study, we examined the long-term effects of monoclonal antibody tocilizumab (TCZ) on cell profiles NMOSD.Monthly IV injections TCZ (8 mg/kg) were administered as an add-on to 19...
Objectives: Multiple sclerosis (MS) is associated with the activation of CD4 + T helper (Th) cells by self-antigen from central nervous system (CNS) to generate pathogenic self-reactive Th cells.Treat-