A5053192443- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Monoclonal and Polyclonal Antibodies Research
- Rheumatoid Arthritis Research and Therapies
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Dermatology and Skin Diseases
- Chemokine receptors and signaling
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- vaccines and immunoinformatics approaches
- Toxin Mechanisms and Immunotoxins
- Mosquito-borne diseases and control
- Allergic Rhinitis and Sensitization
- Asthma and respiratory diseases
- T-cell and Retrovirus Studies
- Immune cells in cancer
- Immune Response and Inflammation
- Influenza Virus Research Studies
- Contact Dermatitis and Allergies
Genesis Research Institute
2018-2025
Maruho (Japan)
2024
National Sagamihara Hospital
2013-2016
Wakayama Medical University
2011-2013
Dokkyo University
2013
Matsutani (Japan)
2011
University of Miami
2008-2011
Tohoku University
2004-2010
Shionogi (Japan)
1994-2003
Futaba (Japan)
2000-2003
Checkpoint inhibitors have demonstrated efficacy in patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). However, the majority of do not benefit from these agents. To improve checkpoint inhibitors, intratumoral (i.t.) injection innate immune activators, TLR7 TLR9 agonists, were tested along programmed death-1 receptor (PD-1) blockade. The combination therapy suppressed tumor growth at primary injected distant sites human papillomavirus-negative (HPV-negative)...
To investigate the duration of remission and low disease activity (LDA) after cessation tocilizumab (TCZ) treatment in rheumatoid arthritis patients who showed or LDA as assessed by DAS28 response to preceding TCZ monotherapy, explore factors contributing prolonged efficacy duration.Disease was monitored for 56 weeks. The rate continued estimated Kaplan-Meier curves.A total 187 were eligible. At baseline this study, median 7.8 years, period 4.0 years 1.5. at 52 weeks 13.4 % according...
A diverse antibody repertoire is primarily generated by the rearrangement of V, D, and J genes subsequent somatic hypermutation (SHM). Class-switch recombination (CSR) produces various isotypes subclasses with different functional properties. Although are considered to be produced both direct sequential CSR, it still not fully understood how SHMs accumulate during process in which generated. Here, we developed a new next-generation sequencing (NGS)-based analysis capable identifying all...
High-throughput sequencing of T cell receptor (TCR) genes is a powerful tool for analyses antigen specificity, clonality and diversity lymphocytes. Here, we developed new TCR repertoire analysis method using 454 DNA technology in combination with an adaptor-ligation mediated polymerase chain reaction (PCR). This allows the amplification all without PCR bias. To compare gene usage, similarity expressed repertoires among individuals, conducted next-generation (NGS) TRA TRB peripheral blood...
Journal Article Immune response to influenza vaccine and pneumococcal polysaccharide under IL-6 signal inhibition therapy with tocilizumab Get access Tomomi Tsuru, Tsuru Medical Co. LTA PS clinic, Fukuoka, Japan Search for other works by this author on: Oxford Academic Google Scholar Kimio Terao, Terao Chugai Pharmaceutical Co., LTD., Tokyo, Miho Murakami, Murakami Department of Regulation, Wakayama University, Wakayama, JapanDepartment Molecular Regulation Intractable Diseases, Institute...
Chemoradiotherapy (CRT) followed by durvalumab is standard for unresectable locally advanced non-small-cell lung cancer (LA-NSCLC). This study assesses how CRT alters the T-cell receptor (TCR) repertoire in CD8 + PD-1 T-cells and its impact on clinical outcomes. prospective study, conducted from November 2019 to May 2021 at three institutions Japan, evaluated diversity of TCR (DE50) phenotypes peripheral blood before after CRT. Forty patients treated with were included. The usage beta...
Abstract Background A pilot clinical study of a Tax peptide‐pulsed dendritic cell (DC) vaccine for adult T‐cell leukaemia/lymphoma (ATL) indicated favourable outcomes. Methods We investigated its anti‐tumour effect by T receptor (TCR) repertoire analysis in samples from an enrolled ATL patient who achieved 10‐year complete remission after DC vaccination. Results In this patient, the dominant residual clones that had persisted following previous treatment entirely disappeared within 3 years...
Monovalent Omicron XBB.1.5 mRNA vaccines were newly developed and approved by the FDA in Autumn 2023 for preventing COVID-19. However, clinical efficacy these is currently lacking. We previously established quantification of antigen-specific antibody sequence (QASAS) method to assess response severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination at level using B-cell receptor (BCR) repertoire assay database (CoV-AbDab). Here, we used this evaluate immunogenicity monovalent...
The importance of high TCR diversity T regulatory (Treg) cells for self-tolerance is poorly understood. To address this issue, was measured Treg after transfer into IL-2Rbeta(-/-) mice, which develop lethal autoimmunity because failed production cells. In study, we show that pretransferred led to selection therapeutic with lower prevented autoimmunity. Pretransferred through substantial peripheral reshaping even more restricted also suppressed autoimmune symptoms. Thus, in a setting severe...
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating condition characterized by and post-exertional malaise, accompanied various signs of neurological autonomic dysfunction. ME/CFS often triggered an infectious episode associated with aberrant immune system. Here we report that disorder skewed B cell receptor gene usage. By applying next-generation sequencing to determine the clone-based IGHV/IGHD/IGHJ repertoires, revealed biased usage several IGHV genes in...
ABSTRACT We analyzed the CD4 + T-lymphocyte responses of two donors who had received Japanese encephalitis virus (JEV) vaccine 6 or 12 months earlier. Bulk culture proliferation assays showed that peripheral blood mononuclear cells (PBMC) responded to JEV antigens (Ag) but also at lower levels West Nile (WNV) and dengue type 1, 2, 4 (D1V, D2V, D4V, respectively) Ag. Five JEV-specific human T-cell clones one subclone were established from PBMC these donors. Two WNV Ag as well Ag, whereas...
Chromium (Cr) causes delayed-type hypersensitivity reactions possibly mediated by accumulating T cells into allergic inflamed skin, which are called irritants or contact dermatitis. However, during development of metal allergy poorly characterized because a suitable animal model is not available. This study aimed to elucidate the skewing T-cell receptor (TCR) repertoire and cytokine profiles in accumulated skin elucidation Cr allergy. A novel was induced two sensitizations plus...
Summary Itching is one of the major clinical symptoms in atopic dermatitis (AD) and complicates management this pathological condition. An animal model AD‐like pruritus would contribute to a better understanding AD could lead development safe effective antipruritic agents. DS non‐hair (DS‐ Nh ) mice raised under conventional conditions spontaneously develop pruritus, which associated with similar human AD. There significant positive correlation between disease severity period scratching...
To evaluate the safety and efficacy of retreatment with tocilizumab (TCZ) in patients who had participated DREAM study (Drug free remission/low disease activity after cessation [Actemar] monotherapy study) experienced loss efficacy.Patients were retreated TCZ or other modifying antirheumatic drugs (DMARDs). Disease was measured using 28-joint score (DAS28) for 12 weeks.A total 164 eligible patients, including 161 within 52 weeks study, resumed treatment: 157 7 DMARDs and/or infliximab. Of...
Metal allergy is categorized as a delayed-type hypersensitivity reaction, and characterized by the recruitment of lymphocytes into sites allergic inflammation. Because unavailability suitable animal models for metal allergy, role T cells in pathogenesis has not been explored. Thus, we developed novel mouse model associated with infiltration multiple injections palladium (Pd) plus lipopolysaccharide footpad. Using this model, footpad-infiltrating terms phenotypic markers, cell receptor (TCR)...