A5007527793- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Advanced MRI Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Alzheimer's disease research and treatments
- Neurological disorders and treatments
- Glioma Diagnosis and Treatment
- Epilepsy research and treatment
- Neurological diseases and metabolism
- Neuroscience and Neuropharmacology Research
- Mitochondrial Function and Pathology
- Genetics and Neurodevelopmental Disorders
- Dementia and Cognitive Impairment Research
- Pharmacological Effects and Toxicity Studies
- Cerebrospinal fluid and hydrocephalus
- Cerebral Palsy and Movement Disorders
- Spinal Dysraphism and Malformations
- Functional Brain Connectivity Studies
- RNA regulation and disease
- Metabolism and Genetic Disorders
- Gear and Bearing Dynamics Analysis
- Botulinum Toxin and Related Neurological Disorders
- Mechanical Engineering and Vibrations Research
- Cervical and Thoracic Myelopathy
Tokyo Metropolitan Neurological Hospital
2014-2024
University of California, San Francisco
2009-2024
San Francisco VA Medical Center
2024
National Center of Neurology and Psychiatry
2009-2023
Tokyo Metropolitan Tama Medical Center
2017
St. Marianna University School of Medicine
2017
Washington Center
2014
University of Washington
2014
Kitasato University
2012
Nippon Steel (Japan)
2010
The purpose of the present retrospective study was to evaluate sensitivity susceptibility-weighted imaging (SWI) compared conventional spin-echo T2-weighted and T2*-weighted images in detecting iron deposition motor cortex amyotrophic lateral sclerosis (ALS) patients comparison with age-matched normal controls. We also investigated etiology low signal referring pathology one autopsy case.This magnetic resonance (MR) included 23 ALS 28 intensity scored by SWI, images. A postmortem patient...
Hypophysitis is one of the well-known adverse effects immune checkpoint inhibitors. Immune inhibitor-induced hypophysitis frequently causes irreversible hypopituitarism, which requires long-term hormone replacement. Despite high frequency and clinical significance, characteristic MR imaging findings have not been established. In present study, we aimed to review extract features hypophysitis.This retrospective international multicenter study comprised 20 patients with melanoma who were being...
MR imaging findings of LYH and pituitary adenomas are similar, but the therapeutic strategies completely different. The purpose this study was to evaluate sellar parasellar in patients with both diseases, as well characteristic clinical findings.Clinical findings, including endocrinologic images 20 22 adenoma, were retrospectively reviewed. We evaluated relation following: 1) PPHI on T1-weighted images, 2) thickened stalk (>3.5 mm), 3) symmetry, 4) enhancement pattern, 5) a dural tail, 6)...
Objective Alzheimer's disease (AD) research has largely concentrated on the study of cognitive decline, but associated behavioral and neuropsychiatric symptoms are equal importance in clinical profile disease. Apathy is most common manifestation AD. Clinical, multimodal neuroimaging studies pathologic apathy AD have suggested an association with frontal dysfunction without a definitive localization. In this study, we examined between white matter integrity using diffusion tensor imaging...
Amygdala enlargement (AE) has been suggested to be a subtype of mesial temporal lobe epilepsy (MTLE). However, most reports related AE have referred imaging studies, and there few regarding surgical pathological findings. The present study was performed clarify the outcomes pathology AE.Eighty patients with drug-resistant MTLE were treated surgically at Tokyo Metropolitan Neurological Hospital between April 2010 July 2013. Of these patients, 11 diagnosed as based on presurgical MRI. Nine...
Multinodular and vacuolating neuronal tumors ( MVNT ) have been referred to as distinctive whose characteristic features include multiple nodules localized in the subcortical white matter. are composed of dysplastic neurons reactive HuC / HuD . A significant overexpression alpha‐internexin INA limited stroma was reported one tumor. Since genetic analyses failed demonstrate any consistent alterations, nosological position well nature , namely, neoplastic or dysplastic, remains unclear. We...
<b>BACKGROUND AND PURPOSE:</b> Patients with agenesis of the corpus callosum (AgCC) exhibit cognitive and behavioral impairments that are not replicated by surgical transection callosum, suggesting other anatomic changes may contribute to observed clinical findings. The purpose this study was determine whether ventral cingulum bundle (VCB) is affected in patients AgCC using diffusion tensor imaging (DTI) volumetry. <b>MATERIALS METHODS:</b> Twelve participants (8 males 4 females; mean age,...
In multiple system atrophy with predominant parkinsonism (MSA-P), several voxel-based morphometry (VBM) studies have revealed gray matter loss; however, the white volume changes been rarely reported. We investigated of as well by VBM. A retrospective MRI study was performed in 20 patients MSA-P and 30 age-matched healthy controls. applied VBM statistical parametric mapping (SPM8) plus diffeomorphic anatomical registration through exponentiated Lie algebra (DARTEL) to explore regional all...
Abstract Purpose To investigate the feasibility of using spatial normalization in combination with diffusion tensor (DT) corticospinal tractography to assess tract (CST) involvement capsular or pericapsular stroke. Materials and Methods Corticospinal tractograms were created segmented out DT imaging (DTI) data from 10 normal volunteers. After was achieved statistical parametric mapping (SPM), whole ensemble used as a map CST. This overlaid on infarction site, which had also been spatially...
Ota M, Ishikawa Sato N, Hori H, Sasayama D, Hattori K, Teraishi T, Nakata Y, Kunugi H. Glutamatergic changes in the cerebral white matter associated with schizophrenic exacerbation. Objective: dysfunction brain has been implicated pathophysiology of schizophrenia. This study was aimed to examine several chemical mediators, including Glx (glutamate + glutamine), using 1 H magnetic resonance spectroscopy (MRS) medicated patients schizophrenia, and without psychotic Method: MRS acquired 24...
ABSTRACT BACKGROUND AND PURPOSE Amygdala enlargement (AE) has been reported as an epileptogenic focus in subtypes of temporal lobe epilepsy (TLE). The purpose this study was to investigate the clinical, morphological, and pathological characteristics AE. METHODS We retrospectively reviewed clinical data imaging findings 23 TLE patients with ipsilateral performed morphological MR analyses using FreeSurfer voxel‐based morphometry (VBM) 14 20 controls whose images were obtained by a 3.0‐Tesla...
In hemimegalencephaly, MR imaging often reveals midsagittal bandlike structures between the 2 lateral ventricles. To determine whether these are aberrant fibers, we retrospectively reviewed them on conventional and prospectively examined by diffusion tensor fiber tract (FT) reconstruction imaging.We images of 26 consecutive patients with hemimegalencephaly neuroradiologists, focusing abnormal structures. The distance anterior horns widths were measured. Prospective analysis was performed in...