A5059174512- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Cardiac Arrest and Resuscitation
- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Trauma and Emergency Care Studies
- Intensive Care Unit Cognitive Disorders
- Venous Thromboembolism Diagnosis and Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Immunotherapy and Immune Responses
- Non-Invasive Vital Sign Monitoring
- Congenital Diaphragmatic Hernia Studies
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Esophageal and GI Pathology
- Emergency and Acute Care Studies
- Tuberculosis Research and Epidemiology
- Vitamin C and Antioxidants Research
- Burn Injury Management and Outcomes
- Inflammasome and immune disorders
- Pleural and Pulmonary Diseases
- Diabetes and associated disorders
- Intramuscular injections and effects
Nagasaki University Hospital
2014-2024
Nagasaki University
2020-2024
Brigham and Women's Hospital
2007-2020
Harvard University
2008-2020
Dana-Farber Brigham Cancer Center
2011
Dana-Farber Cancer Institute
2011
National Institutes of Health
2011
Osaka University
2005-2007
Tosei General Hospital
2004
Shimizu (Japan)
2004
Programmed cell death-1 (PD-1) is a member of the CD28 superfamily that delivers negative signals on interaction with its 2 ligands, PD-L1 and PD-L2. We studied contribution PD-1 pathway to regulation T cells promote atherosclerotic lesion formation inflammation.We show compared Ldlr-/- control mice, Pd1-/-Ldlr-/- mice developed larger lesions more abundant CD4+ CD8+ macrophages, accompanied by higher levels serum tumor necrosis factor-α. Iliac lymph node from proliferated αCD3 or oxidized...
The Japanese Clinical Practice Guidelines for Management of Sepsis and Septic Shock 2020 (J-SSCG 2020), a Japanese-specific set clinical practice guidelines sepsis septic shock created as revised from J-SSCG 2016 jointly by the Society Intensive Care Medicine Association Acute Medicine, was first released in September published February 2021. An English-language version these based on contents original Japanese-language version. purpose this guideline is to assist medical staff making...
In our previous study of patients with early-phase severe traumatic brain injury (TBI), the anti-inflammatory interleukin (IL)-10 concentration was lower in cerebrospinal fluid (CSF) than serum, whereas proinflammatory IL-1β and tumor necrosis factor (TNF)-α concentrations were higher CSF serum. To clarify influence additional on this disproportion between mediators, we compared their serum TBI without injury. All 35 (18 17 injury) had a Glasgow Coma Scale score 8 or less upon admission....
Although it is known that injury enhances the regulatory activity of CD4+ T cells (Tregs), cellular and molecular mechanisms responsible for injury-induced Treg activation remain unclear. This study was designed to investigate compare T-cell receptor (TCR) signaling in Tregs, non-Tregs, CD8+ cells. Specifically, we used phospho-flow cytometry measure expression phosphorylation ZAP-70, protein kinase C θ, nuclear factor activated cells, glycogen synthase 3β FoxP3+ Tregs versus FoxP3−...
Abstract Major injury is widely thought to predispose the injured host opportunistic infections. This idea supported by animal studies showing that major causes reduced resistance polymicrobial sepsis induced cecal ligation and puncture. Although puncture represents a clinically relevant model, we wanted test whether might also lead greater susceptibility peritoneal infection caused single common pathogen, Escherichia coli. Contrary our expectation, show herein LD50 for sham-injured mice was...
We describe the case of a Japanese girl with recurrent optic neuritis and transient cerebral lesions. Antibodies against N-methyl-d-aspartate (NMDA)-type glutamate receptors were detected in both serum cerebrospinal fluid. Results this study suggest that development autoantibodies NMDA-type may play role pathogenesis central nervous system demyelinating diseases.
ABSTRACT Injury initiates local and systemic host responses is known to increase CD4 Treg activity in mice humans. This study uses a TCR transgenic T cell adoptive transfer approach vivo depletion determine specifically the influence of Tregs on antigen-driven reactivity following burn injury mice. We report here that absence recipient donor promotes high expansion increases level reactivity. In contrast, were suppressed significantly injured Treg-replete additional experiments, we found...
The complexity of a radionuclear event would be immense due to varying levels radiation exposures and injuries caused by blast-associated trauma. With this scenario in mind, we developed mouse model mimic as closely possible the potential consequences injury combined (RCI) on survival, immune system phenotype, function. Using burn 137CsCl source irradiator induce injuries, report that immunological response differs significantly from or alone. Mice underwent showed lower survival cecal...
Abstract Aim To analyze characteristics and investigate prognostic indicators of out‐of‐hospital cardiac arrest (OHCA) in a hilly area Japan. Methods A retrospective population‐based study was conducted using the Utstein Registry for 4280 OHCA patients Nagasaki Medical Region (NMR) registered over 10‐year period from 2011 to 2020. The main outcome measure favorable cerebral performance category (CPC 1–2). Sites at which occurred were classified into “sloped places (SPs)” (not easily...
Background: Recovery of cerebral reperfusion after stroke or cardiac arrest can take a long time. We aimed to identify differences in the postischemic recovery physiologic parameters between short and prolonged brain ischemia. Methods: Eighteen Mongolian gerbils were assigned one three groups: 5-minute (G5), 15-minute (G15), 30-minute (G30) With use our original microspectroscopy system, global ischemic was performed. measured changes regional blood flow (r-CBF), microvessel diameter,...
Although the effects of trauma center(TC) were researched in several studies, there have been few studies on changes regional mortality due to implementation a TC. An emergency medical center (EMC) and TC implemented at Nagasaki University Hospital (NUH) for first time region Japan April 2010 October 2011, respectively, they cooperated with each other treating patients. The purpose this study was investigate early population level working cooperation an EMC.This is retrospective using...
It is well known that oxidative stress causes certain diseases and organ damage. However, roles of in the acute phase critical patients remain to be elucidated. This study aimed investigate balance antioxidative system clarify association between mortality critically ill patients. cohort enrolled 247 transported our emergency department by ambulance. Blood was drawn on hospital arrival, serum derivatives reactive oxidant metabolites (dROMs, index) biological antioxidant potential (BAP, were...
It is well known that radiation-induced vasculopathy and arteritis are two of the complications whole brain radiation therapy. Moyamoya syndromes after cranial irradiation among patients with tumors were previously reported. However, we could find only three cases prophylactic for hematological disorders no case before bone marrow transplantation in acute leukemia. We recently treated a boy who developed moyamoya vessels 1.5 years This first report syndrome transplantation. The mechanism...
Severe crush injury results in a high mortality rate because of acute circulatory failure and hyperkalemia. The purpose this study was to evaluate whether administration prophylactic-recombinant human soluble thrombomodulin (rhsTM) and/or fluid-volume resuscitation before reperfusion attenuates severe rats. Both hindlimbs anesthetized rats were compressed for 6 h under blocks weighing 3.5 kg each, followed by 3 reperfusion. In the first group, fluid with normal saline (1 mL/kg/h) performed...
Burn injury initiates an enhanced inflammatory condition referred to as the systemic response syndrome or two-hit phenotype. Prior reports indicated that macrophages respond and demonstrate a heightened reactivity Toll-like receptor stimulation. Since we others observed significant increase in splenic GR-1 F4/80 CD11b burn-injured mice, wished test if these might be primary macrophage subset shows LPS reactivity. We report here burn promoted higher level TNF-α expression GR-1, but not...
Case A 61‐year‐old man who was hospitalized with schizophrenia in a psychiatric hospital drank hot water estimated to be 90°C. Eight hours after injury, laryngopharynx edema gradually progressed, and his breathing deteriorated. Upon arrival at our emergency room, we secured respiratory tract by nasal intubation under bronchoscope. Outcome The improved peaking day 2, he extubated on 18. There were no apparent or esophageal problems, discharged back the 28. Conclusion These types of burns...
We aimed to create a system for monitoring of regional cerebral oxygen saturation (rSO 2) in patients with prehospital cardiopulmonary arrest and clarify the changes rSO 2 during resuscitation.We measured who were transferred by emergency response vehicle Nagasaki University Hospital. developed portable monitor (HAND ai TOS), which is small enough carry treatment. The sensor attached forehead patient monitors continuously treatment transfer.No difficulties experienced transfer. Median time...
Venous thromboembolism (VTE) is a life-threatening complication after trauma. Several studies have reported VTE prophylaxis using low-molecular-weight heparin; however, there no consensus for This study aimed to assess the efficacy and safety of our new anticoagulation therapy protocol unfractionated heparin (UFH) plus intermittent pneumatic compression (IPC) prevent post-traumatic in high-risk trauma patients.This enrolled 70 patients who were admitted emergency medical center Nagasaki...
Abstract CD4+ regulatory T cells (Tregs) are acutely activated by traumatic injury, which suggests that they may react to injury with similar kinetics as memory cells. Here, we used a mouse burn trauma model screen for memory-like cell responses transferring from sham or CD45.1 mice into CD45.2 and performing secondary injuries in recipient mice. Among all subsets were measured, only Tregs expanded response injury. The CD44high/CD62Llow subpopulation, markers indicative of CyTOF (cytometry...
Aim Because severe trauma patients frequently manifest coagulopathy, it is extremely important to detect venous thromboembolism ( VTE ) in the acute phase. However, no reference value for D‐dimer post‐traumatic has been reported given substantial increase its levels after injury. Therefore, this study evaluates ability of our screening criteria using patients. Methods Trauma n = 455) who were admitted emergency medical center during October 2011–June 2015 included study. To prevent ,...
[Background] Recently, the patients with out-of-hospital cardiac arrest are increasing. It is very important to do chest compression continuously for return of spontaneous circulation (ROSC). But we can not but stop during checking pulse every few minutes. We reported that Regional cerebral Oxygen Saturation (rSO2) value was elevated by manual and mechanical increased a little rSO2 on CPR without ROSC became good parameter in single center study. [Purpose] The purpose this study evaluate...
Infection in patients with systemic inflammation is difficult to diagnose a single biomarker. We aimed clarify the time course of change gene expression profile innate immune receptors infectious or sterile and establish an early diagnostic method using canonical discriminant analysis (CDA) profile.To compare inflammation, we used cecal ligation puncture (CLP) 20% full-thickness burn injury (Burn) models. C57BL/6 mice underwent sham treatment (n = 9 × three groups), CLP 12 Burn groups)...