A5101792890- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Cardiomyopathy and Myosin Studies
- Coronary Interventions and Diagnostics
- Plasma Applications and Diagnostics
- Cardiac tumors and thrombi
- Cardiovascular Health and Disease Prevention
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Parathyroid Disorders and Treatments
- Cardiovascular Disease and Adiposity
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Issues in Pregnancy
- Pulmonary Hypertension Research and Treatments
- Cardiac Fibrosis and Remodeling
- Cardiac Valve Diseases and Treatments
- Blood Pressure and Hypertension Studies
- Heart Failure Treatment and Management
- Cardiovascular Syncope and Autonomic Disorders
- Peripheral Artery Disease Management
- Takotsubo Cardiomyopathy and Associated Phenomena
Nagasaki University
2016-2025
Nagasaki University Hospital
2006-2025
Tokyo Institute of Technology
2015-2022
Foundation of Cardiac Surgery Development
2022
Ministry of Health Labour and Welfare
2020
Foundation for Ichthyosis and Related Skin Types
2016-2018
Sasebo City General Hospital
2013-2018
Kokura Memorial Hospital
2016
Kyowa Hakko Kirin (Singapore)
2015
Kumamoto University
2000-2013
Article abstract—We followed 828 nondemented residents of Hisayama Town, Kyushu, Japan, aged 65 years or older (88.3% the elderly population) for 7 starting in 1985 order to determine type-specific incidence dementia and its risk factors general Japanese population. Only two subjects were lost follow-up, during which period 103 developed dementia. Morphologic examination brains 89 (86.4%) was made by autopsy CT. We initial diagnosis based on DSM-111-R criteria, with diagnoses vascular (VD)...
Background —Angiotensin II (Ang II) is implicated in cardiac remodeling and increasingly recognized for its profibrotic activity. Methods Results —Because little known about the direct cellular effects of Ang on human fibroblasts, we isolated fibroblasts from ventricles explanted hearts added (100 nmol/L) to determine role growth, extracellular matrix accumulation, adhesion. To assess which receptor involved, was presence irbesartan (10 μmol/L), a specific AT 1 antagonist; PD 123319 2...
4H-SiC(0001), (0001), and (1120) have been directly oxidized by N 2 O at 1300°C, metal–oxide–semiconductor (MOS) interfaces characterized. The interface state density has significantly reduced oxidation on any face, compared to conventional wet 1150°C. Planar n-channel field-effect transistors (MOSFETs) fabricated (0001) faces shown effective channel mobilities of 26, 43, 78 cm /Vs, respectively. Secondary ion mass spectrometry analyses revealed a clear pileup nitrogen atoms near the MOS...
The purpose of this study was to determine the effect peroxisome proliferator-activated receptor γ-(PPARγ) ligands troglitazone (TRO), rosiglitazone (RSG), and 15-deoxy-Δ prostaglandin J2 (15d-PGJ2) on vascular smooth muscle cell (VSMC) migration directed by multiple chemoattractants. Involvement mitogen-activated protein kinase (MAPK) in also examined, because TRO previously shown inhibit nuclear events stimulated pathway during mitogenic signaling VSMCs. Migration rat aortic VSMCs induced...
Abstract —Migration of vascular smooth muscle cells (VSMC) is a key event in neointimal formation and atherosclerosis that may be linked to the accumulation inflammatory release chemotactic cytokines. Tumor necrosis factor-α (TNF-α) induces chemotaxis fibroblasts, but little known about signaling by TNF-α VSMC. The aim this study was investigate role VSMC migration elucidate pathways mediating action. (50 400 U/mL) induced cultured rat aortic dose-dependent manner. Because activation...
Hypertension in patients with chronic kidney disease (CKD) strongly associates cardiovascular events. Among CKD, reducing the accumulation of uremic toxins may protect against development hypertension and progression renal damage, but there are no established therapies to accomplish this. Here, overexpression human kidney-specific organic anion transporter SLCO4C1 rat reduced hypertension, cardiomegaly, inflammation setting failure. In addition, decreased plasma levels guanidino succinate,...
Angiotensin II (Ang II) plays an important role in cardiac remodeling through stimulation of proliferation and extracellular matrix (ECM) production fibroblasts. Integrins are a family transmembrane receptors that mediate the attachment cells to ECM. We hypothesized Ang regulation integrins further contributes its remodeling. cultured adult rat fibroblasts with without (100 nmol/L) determine effects on mRNA protein levels integrins, as well alpha-actinin other cytoskeletal proteins link at...
Ovarian stimulation induced by follicle-stimulating hormone and human chorionic gonadotrophin (hCG) is commonly used in assisted reproductive technology to increase embryo production. However, recent clinical animal studies have shown that ovarian disrupts endometrial function development adversely affects pregnancy outcomes. How impairs establishment the precise mechanisms which this reduces chances of conception remain unclear. In study, we first demonstrated using hCG alone implantation,...
Abstract Aims To examine the effects of a 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. Methods and results In this multicenter, prospective, randomized, open-label, blinded-endpoint investigator-initiated clinical trial, adults haemoglobin A1C (HbA1c) 6.0–10.0% (42–86 mmol/mol) were randomized equally to (50 mg daily) non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use standard-care (control group) for followed-up 24 months....
A 17-year-old Japanese boy was admitted to our hospital with intermittent claudication. He belonged a weightlifting team at high school. had occasionally dropped lightweight lifting weights on his right foot. Arteriography of the anterior and posterior tibial arteries revealed 4-cm total occlusion in dorsalis pedis artery (DPA). Intravascular ultrasonography intimal thickening thrombus formation diagnosed DPA due damage caused by weightlifting. thrombosis may occur young athletes who do not...
A 65-year-old woman was admitted to our hospital with heart failure secondary aortic regurgitation and paroxysmal atrial fibrillation. During surgery for valve-sparing root replacement, a biopsy obtained from the right atrium because of AF mild LV hypokinesis. histopathological examination revealed natriuretic peptide amyloidosis, patient clinically diagnosed isolated amyloidosis (IAA). Although IAA is rarely clinically, it should be considered in patients failure.
Background Fibrosis, as well myocyte hypertrophy, is the major determinant of prognosis in hypertrophic cardiomyopathy (HCM). Valsartan, an angiotensin II type 1 receptor blocker, may improve myocardial fibrosis patients with HCM. Methods and Results Twenty-three HCM were randomly divided into 2 groups: 11 had valsartan added to conventional treatment (V group) 12 received therapy (C group). Plasma concentrations brain natriuretic peptide (BNP), troponin T (TnT), aldosterone (ALDO),...
Peripartum cardiomyopathy (PPCM) is a form of heart failure that affects women late in pregnancy or early peripartum. The present report describes case patient with PPCM demonstrated by magnetic resonance imaging (MRI) gadolinium enhancement the left ventricle (LV). MRI improved associated recovery cardiac function. Endomyocardial biopsy showed mild cell infiltration and fibrosis. Thus, may be useful for evaluation myocardial damage to predict outcome PPCM.
Protein introduction into cells is more difficult in plants than mammalian cells, although it was reported that protein successful shoot apical meristem and leaves only together with a cell-penetrating peptide. In this study, we tried to introduce superfolder green fluorescent (sGFP)-fused adenylate cyclase as reporter without peptide the of tobacco by treatment atmospheric non-thermal plasmas. For purpose, CO2 or N2 plasma generated using multi-gas jet. Confocal microscopy indicated sGFP...
Comparisons between the resting full-cycle ratio (RFR), a new physiological index, and fractional flow reserve (FFR) in terms of prognostic value are limited. We aimed to identify concordance RFR FFR determine stability measured RFR.We 161 coronary arteries 119 patients classified data using known cutoffs for (≤0.80) (≤0.89) into groups; high (high FFR/low RFR) group, low (low FFR/high group. The rates these groups were 42.2% (68/161), 4.4% (7/161), 14.3% (23/161), 39.1% (63/161),...