A5038000368- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Cardiovascular and exercise physiology
- Cardiac Health and Mental Health
- Venous Thromboembolism Diagnosis and Management
- Congenital Heart Disease Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Imaging and Diagnostics
- Cardiovascular Effects of Exercise
- Cardiovascular and Diving-Related Complications
- Obstructive Sleep Apnea Research
- Cardiac pacing and defibrillation studies
- Respiratory Support and Mechanisms
- Cardiac Arrest and Resuscitation
- Cardiovascular Issues in Pregnancy
- Cardiac tumors and thrombi
- Central Venous Catheters and Hemodialysis
- Cardiovascular Disease and Adiposity
- Cardiac Valve Diseases and Treatments
- Heart Failure Treatment and Management
- Adipose Tissue and Metabolism
- Heart Rate Variability and Autonomic Control
- Erythropoietin and Anemia Treatment
- Thyroid Disorders and Treatments
- Neuroscience of respiration and sleep
Tohoku Medical and Pharmaceutical University
2024
Fujita Health University
2023-2024
National Cerebral and Cardiovascular Center
2013-2023
Tohoku University
2005-2022
Tohoku Medical and Pharmaceutical University Hospital
2022
Okayama Medical Center
2022
National Hospital Organization
2022
Policlinico S.Orsola-Malpighi
2022
Iwate Prefectural Central Hospital
2009-2013
Tohoku University Hospital
2008
Balloon pulmonary angioplasty (BPA) has been reported to improve haemodynamics and functional capacity, with an acceptable risk, in patients chronic thromboembolic hypertension (CTEPH) who are not candidates for endarterectomy. However, right ventricular (RV) function, important predictor CTEPH, remains be elucidated. We aimed examine the impact of BPA on RV remodelling dysfunction relative haemodynamic improvements inoperable CTEPH. 20 consecutive CTEPH underwent cardiovascular magnetic...
Hypertension in patients with chronic kidney disease (CKD) strongly associates cardiovascular events. Among CKD, reducing the accumulation of uremic toxins may protect against development hypertension and progression renal damage, but there are no established therapies to accomplish this. Here, overexpression human kidney-specific organic anion transporter SLCO4C1 rat reduced hypertension, cardiomegaly, inflammation setting failure. In addition, decreased plasma levels guanidino succinate,...
Journal Article Assessment of Biological Age by Multiple Regression Analysis Get access Toshiyuki Furukawa, MD, PhD, PhD Search for other works this author on: Oxford Academic PubMed Google Scholar Michitoshi Inoue, Fumihiko Kajiya, MD Hiroshi Inada, Seiichi Takasugi, Sugao Fukui, Takeda, Abe, 1First Dept. Medicine, Osaka Univ. Medical SchoolOsaka, Japan. Gerontology, Volume 30, Issue 4, July 1975, Pages 422–434, https://doi.org/10.1093/geronj/30.4.422 Published: 01 1975
<h3>Objective</h3> To determine safety and efficacy of cardiac rehabilitation (CR) initiated immediately following balloon pulmonary angioplasty (BPA) in patients with inoperable chronic thromboembolic hypertension (CTEPH) who presented continuing exercise intolerance symptoms on effort even after a course BPA; 2–8 sessions/patient. <h3>Methods</h3> Forty-one consecutive CTEPH underwent their final BPA improved resting mean arterial pressure 24.7±5.5 mm Hg suffered remaining were...
Background The specific incidence of thrombotic pulmonary embolism (PE), tumor PE and invasion into large veins according to type site remains unclear. Methods Results A total 65,181 cancer patients were identified from 98,736 postmortem examinations. Thrombotic occurred in 2.32% all comprised 88.6% the number events. was high those with adenocarcinoma, leukemia cell carcinoma, low hepatic carcinoma. when present hematogenous tissue, lungs, ovaries, pancreas biliary system, liver. carcinoma...
Diastolic heart failure (DHF) is a major cardiovascular disorder with poor prognosis; however, its molecular mechanism still remains to be fully elucidated. We have previously demonstrated the important roles of Rho-kinase pathway in mechanisms fibrosis/hypertrophy and oxidative stress, but not examined development failure. Therefore, we this study whether also involved pathogenesis DHF Dahl salt-sensitive rats, an established animal model DHF. They were maintained or without fasudil,...
Heart failure is the most common cardiovascular disease with high mortality and morbidity. Both enhanced microtubule polymerization cardiomyocyte apoptosis are involved in pathogenesis of heart failure. However, link between two mechanisms remains to be elucidated. In this study, we thus address important issue cultured cardiomyocytes from Wistar rats vitro angiotensin II (ATII)-infused vivo. Confocal microscopy examination showed that rat cardiomyocytes, micrographic density microtubules...
Abstract Chronic thromboembolic pulmonary hypertension (CTEPH) is a chronic disease that can rapidly deteriorate into circulatory collapse when complicated by comorbidities. We herein describe case involving 43‐year‐old woman with class III obesity (body mass index of 63 kg/m 2 ) and severe CTEPH associated total occlusion the left main artery who subsequently developed along multiple comorbidities, including acute kidney injury, tuberculosis, catastrophic antiphospholipid syndrome. The...
Chronic left ventricular (LV) pressure overload induced by hypertension is one of the most common causes heart failure. Earlier reports have shown cardioprotective effects erythropoietin (EPO). In present study, we tested hypothesis that recombinant human EPO exerts a protective effect against pressure-overload LV remodeling. Mice subjected to transverse aortic constriction (TAC) (n = 70) were randomly assigned treatment with phosphate buffer solution (PBS) (TAC-PBS) or (2,000 U/kg twice...
Sleep-disordered breathing (SDB) has been reported to influence mortality and occurrence of ventricular tachyarrhythmia in patients with chronic heart failure (CHF). It remains be elucidated, however, whether respiratory therapy (RT) can affect the fatal CHF SDB.We prospectively examined severity SDB was associated cardiac events and, if so, RT for improved prognosis. We enrolled 95 stable CHF, whom on overnight polygraphy. The quantified using apnea-hypopnea index (AHI). All AHI ≥10 (n=42)...
Although balloon pulmonary angioplasty (BPA) improves symptoms and hemodynamics in patients with chronic thromboembolic hypertension (CTEPH), the effects of riociguat on exercise capacity after BPA remain to be elucidated. This study was a single-center, prospective, randomized, open-label trial. From November 2015 2018, we prospectively examined 21 CTEPH (65 ± 9 years old, M/F 2/19) who showed hemodynamic improvement mean arterial pressure (mPAP) < 30 mmHg without any vasodilators. We...
Whether the magnitude and predictors of improvement in exercise capacity after cardiac rehabilitation (CR) are same between young-old (YO) octogenarian (OCT) patients with acute myocardial infarction (AMI) is unknown.
Background: The AmplatzerTM PFO Occluder was approved for marketing in Japan May 2019, and the Amplatzer Post-marketing Surveillance (PFO PMS) study initiated December 2019. This analysis presents 30-day clinical outcomes PMS patients.
Background:The efficacy of exercise training (ET) programs and its relationship with long-term clinical outcomes in advanced heart failure (HF) patients high levels B-type natriuretic peptide (BNP) remain uncertain.
Pulmonary tumor thrombotic microangiopathy (PTTM) is a specific type of embolism in the small and medium pulmonary arteries, leading to rapid progressive hypertension. Antemortem diagnosis PTTM extremely difficult. We encountered three patients who were histopathologically or clinically diagnosed with PTTM. In all cases, lung perfused blood volume (PBV) images on dual-energy computed tomography (CT) demonstrated multiple subpleural wedge-shaped defects no evidence CT angiography. The PBV...