Yutaka Kawabata
A5078979905- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Metabolism, Diabetes, and Cancer
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infective Endocarditis Diagnosis and Management
- Coronary Interventions and Diagnostics
- Lipoproteins and Cardiovascular Health
- Actinomycetales infections and treatment
- Vascular Procedures and Complications
- Ion Transport and Channel Regulation
- Medical Imaging and Pathology Studies
- Bone and Joint Diseases
- Atherosclerosis and Cardiovascular Diseases
- Bone Metabolism and Diseases
- Regulation of Appetite and Obesity
- Coronary Artery Anomalies
- Renin-Angiotensin System Studies
- Inflammasome and immune disorders
- interferon and immune responses
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Antimicrobial Resistance in Staphylococcus
- Parathyroid Disorders and Treatments
- Atrial Fibrillation Management and Outcomes
Tokushima University Hospital
2018-2025
Tokushima University
2016-2023
Osaka University of Pharmaceutical Sciences
2013
Lifestyle-related diseases promote atherosclerosis, a chronic inflammatory disease; however, the molecular mechanism remains largely unknown. Endogenous DNA fragments released under over-nutrient condition provoke sterile inflammation through recognition by sensors. Here, we investigated role of stimulator interferon genes (STING), cytosolic sensor, in atherogenesis.Apolipoprotein E-deficient (Apoe-/-) mice fed western-type diet (WTD), hypercholesterolaemic mouse model, showed higher STING...
Abstract Aims To examine the effects of a 24-month treatment with ipragliflozin on carotid intima-media thickness (IMT) in type 2 diabetes patients. Methods and results In this multicenter, prospective, randomized, open-label, blinded-endpoint investigator-initiated clinical trial, adults haemoglobin A1C (HbA1c) 6.0–10.0% (42–86 mmol/mol) were randomized equally to (50 mg daily) non-sodium-glucose cotransporter-2 (SGLT2) inhibitor use standard-care (control group) for followed-up 24 months....
ABSTRACT Background Speckles tracking echocardiography imaging enables clinicians to detect subtle systolic dysfunction. The aim of the present study was elucidate differences in speckle echocardiographic findings between immunoglobulin light chain amyloid cardiomyopathy (AL‐CM) and transthyretin (TTR‐CM). Methods patients with a confirmed diagnosis cardiac amyloidosis through biopsy from March 2013 October 2022 were included. relative apical sparing index (RASI) calculated using by...
The coronary adventitia has recently attracted attention as a source of inflammation because it harbors nutrient blood vessels, termed the vasa vasorum (VV). This study assessed link between local in adjacent epicardial adipose tissue (EAT) and arterial atherosclerosis fresh cadavers.
The renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP) regulate body fluids. Although conventional diuretics have been used for treating heart failure, they activate RAAS exacerbate renal function. Tolvaptan, a newly developed vasopressin-2 receptor antagonist, elicits aquaresis improves volume overload in failure patients, however, the predictors of tolvaptan effectiveness influence on function according to therapy are not established. We evaluated 26 chronic...
Abstract Background We assessed the impact of 24 months treatment with ipragliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on endothelial function in patients type diabetes as sub-analysis PROTECT study. Methods In study, were randomized to receive either standard antihyperglycemic (control group, n = 241 ) or add-on ipragliflozin (ipragliflozin 241) 1:1 ratio. Among 482 flow-mediated vasodilation (FMD) was 32 control group and 26 before after treatment. Results HbA1c levels...
It is speculated that statin therapy modulates the synthesis of polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA) and docosahexaenoic (DHA). However, data available on effects serum levels PUFA subsequent impact in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS) are limited.A total 120 ACS who received emergent stent implantation, follow-up angiography to evaluate ISR, new were enrolled. We measured lipids at onset angiography.The revealed 38 ISR...
Coronary intraplaque microluminal structures (MS) are associated with plaque vulnerability, and the inward progression of vascular inflammation from adventitia towards media intima has also been demonstrated. Therefore, in present study we investigated relationships among MS, local adjacent epicardial adipose tissue (EAT), coronary characteristics.
Aortic valve calcification (AVC), which causes aortic stenosis (AS), is more common in elderly persons. Controlling for conventional risk variables did not, however, reduce the incidence of AS. Thus, residual factors AS should be identified. We enrolled 513 patients who underwent coronary angiography with computed tomography because suspicion artery disease (CAD) or ruling out CAD before replacement. Calcium volume was calculated a commercially available application. Conventional and...
The COVID-19 pandemic has caused an unprecedented disruption in medical education. Students and lecturers had to adapt online current study aimed investigate the level of satisfaction future preference for lectures among clinical clerkship students elucidated factors that affect these outcomes.We selected a sample 114 undergoing during pandemic. We conducted onsite before after outbreak. A survey was conducted, included 17 lecturers. average scores total related were computed.Students' on...
Objectives. Cilnidipine, an L-/N-type calcium channel blocker (CCB), has unique organ-protective properties due to suppression of hyperactivity in the sympathetic nervous system and renin-angiotensin (RAS). In this study, we hypothesized that cilnidipine might exert a renoprotective effect by suppressing RAS. Methods. A total 25 hypertensive patients receiving RAS inhibitor were randomly assigned (n = 12) or amlodipine 13) group. The effects on proteinuria angiotensin II–renin feedback...
[Background]: Evidence on the long-term prognosis of stent-less percutaneous coronary intervention (PCI) using paclitaxel-coated balloons (PBCs) is becoming established, however some prognostic indicators remain unexplored. Recently, elevated blood lipoprotein(a) levels are gaining attention as an independent risk factor for development atherosclerosis. We hypothesized that would also adversely affect outcome PCI. [Object]: The aim this study to investigate association between and outcomes...
Infective endocarditis (IE) may be acquired in the community as community-acquired (CA) IE or healthcare setting. In Japan, cases of CA-methicillin-resistant Staphylococcus aureus (MRSA) infection skin have been increasing. CA-MRSA strains, including USA300 clone, higher pathogenicity and are more destructive to tissue than healthcare-associated MRSA strains because toxins they produce, arginine-catabolic mobile element (ACME) Panton-Valentine leukocidin (PVL). However, only a few induced by...
Transthyretin amyloidosis (ATTR) variant is a life-threatening hereditary disease predominantly affecting the peripheral nervous system and heart. Tafamidis, which prevents deposition of amyloid by stabilizing transthyretin, available for treatment neuropathy cardiomyopathy ATTR. However, whether tafamidis could eliminate established deposits improve cardiac function remains unknown. We reported case regression left ventricular hypertrophy after therapy in patient with an ATTR variant. J....
Primary non-Hodgkin bone lymphoma (PBL) can involve solitary or multiple destructive lesions such as those of the femur pelvis humerus, and some cases have osteolytic lesions. PBL is a rare disease in adults. Thus, rarely considered differential diagnosis tumor. In addition, be underdiagnosed because patients do not experience symptoms show objective abnormalities early stage. Here, we reported an elderly patient with bones, including cranial femoral bones that were fractured due to falling....
There have been reports of true aneurysm the posterior tibial artery, but only three described artery at ankle, and there has one report tarsal tunnel syndrome caused by this artery. In case report, we describe a rare septic presenting as which was found after anterior arthroscopic debridement ankle in 55-year-old man.13 years earlier, patient had undergone aortic valve replacement for severe regurgitation infective endocarditis with vegetations. Since then, treated oral anticoagulant...
Introduction: Conventional PCI with stenting in high bleeding risk (HBR) patients is associated withhigher all-cause mortality rates and complications. To minimize DAPT duration, stentlessPCI using drug-coated balloons (DCB) increasingly favored. However, there a lack ofcomprehensive long-term outcome data on stentless therapy HBR within real-worldclinical practice. Research Questions: Do discernible disparities exist the extended-term ramifications of treatment utilizing DCB between...