A5008804622- Cardiovascular Health and Disease Prevention
- Cardiovascular Disease and Adiposity
- Systemic Lupus Erythematosus Research
- Diabetes Treatment and Management
- Rheumatoid Arthritis Research and Therapies
- Herpesvirus Infections and Treatments
- Blood Pressure and Hypertension Studies
- Fatty Acid Research and Health
- Chronic Lymphocytic Leukemia Research
- Metabolism, Diabetes, and Cancer
- Cardiovascular Function and Risk Factors
- Chemical synthesis and alkaloids
- Structural and Chemical Analysis of Organic and Inorganic Compounds
- Oxidative Organic Chemistry Reactions
- Forensic and Genetic Research
- Lipid metabolism and disorders
- Advanced Synthetic Organic Chemistry
- Autoimmune and Inflammatory Disorders Research
- Vasculitis and related conditions
- Muscle and Compartmental Disorders
- Synthesis and Characterization of Heterocyclic Compounds
- Quantum-Dot Cellular Automata
- Bartonella species infections research
- Pharmacology and Obesity Treatment
- Alkaloids: synthesis and pharmacology
Osaka Metropolitan University
2022-2025
Osaka City University
2017-2023
Imari Arita Kyoritsu Hospital
2022
Kyushu University
2013
Shizuoka City Shimizu Hospital
2010
Kagoshima University
1958
Abstract Objectives To investigate the predictive factors for difficult-to-treat rheumatoid arthritis (D2T RA) and assess efficacy of biologic DMARDs (bDMARDs) Janus kinase inhibitors (JAKi). Methods Retrospective analysis was conducted on data from ANSWER cohort comprising 3623 RA patients treated with bDMARDs or JAKi in Japan. Multivariate Cox proportional hazards modelling used to analyse hazard ratios (HRs) treatment retention. Results Of patients, 450 (12.4%) met first two criteria...
ABSTRACT Lymphoproliferative disorders (LPDs) are serious complications that arise in patients with rheumatoid arthritis (RA) receiving immunosuppressive drugs (ISDs). Here, we reported a 73-year-old woman diagnosed RA at 60 years of age and treated methotrexate, bucillamine, prednisolone, infliximab. She was referred to our hospital, Osaka Metropolitan University Hospital, general malaise, pancytopenia, right adrenal mass, enlarged periaortic lymph nodes. Epstein–Barr virus detected serum....
In assessing the effects of smoking cessation on endothelial function, low-flow-mediated constriction (L-FMC) may provide complementary information to flow-mediated dilation (FMD). However, value total (FMTD), an index that incorporates L-FMC into FMD, remains underreported. We aimed evaluate effect as assessed by FMD and FMTD, clarify its associated clinical factors. enrolled 118 consecutive current smokers without previous coronary artery disease (72.9% were men; age: 59 ± 11 years) who...
Abstract Background We assessed the impact of 24 months treatment with ipragliflozin, a sodium-glucose cotransporter 2 (SGLT2) inhibitor, on endothelial function in patients type diabetes as sub-analysis PROTECT study. Methods In study, were randomized to receive either standard antihyperglycemic (control group, n = 241 ) or add-on ipragliflozin (ipragliflozin 241) 1:1 ratio. Among 482 flow-mediated vasodilation (FMD) was 32 control group and 26 before after treatment. Results HbA1c levels...
二次性副甲状腺機能亢進症治療薬シナカルセト塩酸塩（以下シナカルセト）の有害事象として上部消化管症状が頻繁に認められる．これは消化管に存在するカルシウム受容体（以下CaSR）の影響が考えられる．上部消化管機能を胃酸分泌能（胃内pH・血中ガストリン濃度・血中ペプシノーゲン濃度）と胃排出能（アセトアミノフェン法）にて評価した．シナカルセト使用後に血中ガストリン濃度の上昇はみられたが胃酸分泌に明らかな変化はみられなかった．シナカルセト非使用時とくらべ使用時には胃排出能の遅延が認められた．シナカルセトによる胃排出能抑制の強い症例に上部消化管症状がよくみられた．シナカルセトを服用することで消化管に存在するCaSRに擬似的なCa2+負荷が加わり，アセチルコリン遊離が抑制され副交感神経系の抑制による症状が起こることが示唆された．この上部消化管症状に対する対策としては，胃の内容物ができるだけ少ない時間帯や胃排出能が亢進している透析後にシナカルセトを服用し，胃排出能を促進するような健胃消化剤・アセチルコリン作動薬・プロスタグランディン製剤などを使用することが有効であった．制酸剤の効果は定かでなかった...
We herein report a case of Addison's disease caused by tuberculosis characterized atypical hyperpigmentation, noted as exacerbation the pigmentation freckles and occurrence new freckles, that was diagnosed in presence active pulmonary tuberculosis. The clinical condition patient markedly ameliorated administration hydrocortisone anti-tuberculosis agents. When and/or are noted, should be considered part differential diagnosis. In addition, needs to assumed whenever we treat patients with...
Detecting and treating dementia at an early stage are important. Although the Revised Hasegawa Dementia Scale (HDS-R) is commonly used to detect dementia, it takes about 10 min complete. In contrast, 1-min animal test (OMAT) only 1 complete may be a helpful screening for general practitioners in deciding whether proceed with administering further diagnostic tests such as HDS-R. We sought examine relationship between OMAT HDS-R scores, determine cut-off score that balanced sensitivity...
<title>Abstract</title> Background Janus kinase (JAK) inhibitors have emerged as a new class of disease-modifying anti-rheumatic drugs in the treatment rheumatoid arthritis (RA). However, herpes zoster is one common adverse events JAK inhibitors, including upadacitinib, which especially high Japanese patients with RA compared to those from Western countries. Recombinant vaccine (Shingrix®) an adjuvanted subunit containing varicella-zoster virus (VZV) glycoprotein E (gE) that effective adults...
: Janus kinase (JAK) inhibitors have emerged as a new class of disease-modifying anti-rheumatic drugs in the treatment rheumatoid arthritis (RA). However, herpes zoster is one common adverse events JAK inhibitors, including upadacitinib, which especially high Japanese patients with RA compared to those from Western countries. Recombinant vaccine (Shingrix
慢性維持透析患者の高齢化, 透析期間の長期化が進んでおり, 透析患者の健康状態の維持・向上させるための一つの手段として運動療法の重要性が高まっている. 一般的な血液透析の場合, 透析日は時間的制約や透析後の疲労感により身体活動量が低下するため, 透析施行中の運動療法の必要性は高い. 透析施行中の自転車エルゴメーターやゴムチューブなど運動器具を用いた運動療法により透析患者の運動機能やquality of life (QOL) が向上すると報告されている. 本研究では当院外来血液透析患者23名を対象とし, 運動器具を用いない簡便な方法で下肢の筋力強化運動をセルフトレーニングにて12週間実施し, 移動能力・QOLの効果を検討した. 歩行・立ち上がり能力, 膝伸展筋力の向上など移動能力が改善し, 日常役割機能の向上やQOLの改善を認めた. われわれが施行した運動療法においても移動能力やQOLの向上が示唆された.
Abstract Aus den Tetrahydroisochinolinen (Ia)‐(Ic) erhält man mit HCl in Äthanol die entsprechenden phenolischen Isochinoline (II) und Tetrahydroprotoberberine (III).
1. I took 5.520 (2.740 males and 2.780 females) of the people living in southern part Satuma Peninsula as examples Kyushu inhabitants from among all Japanese to examine frequency occurrence four basic fingerprints. And prints cast males, a type is 1.5%±0.07%; r 3.2%±0.1%; u 54.6%±0.30%; w 40.7%±0.29%. case females, 2.1%±0.08%, 2.6%±0.09%, 59.1%±0.29%, 36.2%±0.28%.2. When above mentioned each fingerprints compared with that representative one rase, it found there resemblance east-share...
Abstract A 42‐year‐old man with schizophrenia was referred to our hospital after 2 weeks of worsening fatigue. His hemoglobin level 2.8 g/ dL owing folic acid deficiency stemming from alcohol abuse and consumption unbalanced meals. We induced behavioral changes in the patient by motivational interviewing. had direct methodical conversations medical staff involved as well his family, established new social support for him public assistance. These have resulted maintaining a favorable...
目的：情報通信技術を活用した事前授業とシミュレータ演習を合体したブレンド型授業を導入した．
Abstract Background Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are well-known for preventing cardiovascular disease. Among n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) play key roles in diseases. However, the effects of PUFAs have been examined under conditions simultaneous administration EPA DHA majority clinical investigations effect purified is still controversial. has reported to improve endothelial dysfunction. Although several mechanisms underlying on function...