A5048478528- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Bone and Joint Diseases
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Bone health and osteoporosis research
- Liver Disease Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Knee injuries and reconstruction techniques
- Bone health and treatments
- Osteoarthritis Treatment and Mechanisms
- Nutrition and Health in Aging
- Orthopedic Surgery and Rehabilitation
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Psoriasis: Treatment and Pathogenesis
- Lymphoma Diagnosis and Treatment
- Musculoskeletal synovial abnormalities and treatments
- Cytokine Signaling Pathways and Interactions
- Immunodeficiency and Autoimmune Disorders
- Vitamin D Research Studies
- Hematological disorders and diagnostics
- Mesenchymal stem cell research
- Advanced MRI Techniques and Applications
- Foot and Ankle Surgery
Osaka Metropolitan University
2022-2025
Tokyo Metropolitan University
2023-2024
Osaka City University
2013-2022
Yodogawa Christian Hospital
2019-2021
Cleveland Clinic
2018-2020
Cleveland Clinic Lerner College of Medicine
2020
University of California, San Francisco
2018-2019
Takeda (Japan)
2018
Eisai (Japan)
2018
Astellas Pharma (Japan)
2018
Adipose-derived stem cells (ADSCs) have anti-inflammatory and regenerative properties. The purpose of this study was to investigate the effect locally administered ADSCs in a rheumatoid arthritis (RA) mouse model. In an vivo experiment, single-cell three dimensionally-cultured ADSC spheroids were injected intra-articularly into knees RA model mice histologically assessed. Marked improvement synovial inflammation articular cartilage regeneration found ADSC-treated mice. Proliferation,...
Shohei Anno, M.D., Kentaro Inui, Ph.D., Masahiro Tada, Yuko Sugioka, Tadashi Okano, Ph.D.,, Kenji Mamoto, Tatsuya Koike, Ph.D.. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2024.0130
Objectives This study aimed to clarify the associations between metabolic syndrome (MetS) and rheumatoid arthritis (RA), MetS dietary factors in RA patients. Methods Data were analyzed from a prospective cohort that began 2010, comprising 208 patients 205 gender- age-matched controls. The components (blood pressure, lipid metabolism, glucose waist circumference) evaluated up 2017. Dietary intake was assessed 2011. effect of covariates for development among participants without 2010 tested...
The effect of serum 25-hydroxycalciferol [25(OH)D] on rheumatoid arthritis (RA) activity remains controversial. This study was undertaken with an aim to clarify the relationship between 25(OH)D and RA activity, determine effects dietary vitamin D intake age level.A total 208 outpatients were matched according sex 205 individuals without (controls) from TOMORROW (UMIN000003876). We excluded 27 patients 19 control subjects who had been prescribed medication or taking supplements. Vitamin...
Objectives: Osteoporosis is one of the complications in patients with rheumatoid arthritis (RA). In this study, we researched morbidity existing vertebral fractures and risk factors for RA. Methods: This study included 413 participants, 208 RA, 205 age- sex-matched controls without Clinical data, radiographic assessment fracture from T4 to L4 thoracic lumber spine, bone mineral density (BMD), metabolic markers (BMM) were analyzed. Results: Vertebral observed more frequently, severe multiple...
Objective: Patients with rheumatoid arthritis (RA) have been recognized to experience falls frequently due functional disabilities. The aim of this study was prospectively investigate factors influencing in patients RA compared controls. Methods: We the frequency 208 and 205 age- sex-matched volunteers for four years analyzed risk using multivariate regression analysis. Results: No significant difference incidence rate (/person-year) between (median [interquartile range]: 0 [0, 0.5])...
MRI acceleration using deep learning (DL) convolutional neural networks (CNNs) is a novel technique with great promise. Increasing the number of layers may allow for more accurate image reconstruction. Studies on evaluating diagnostic interchangeability DL reconstructed knee magnetic resonance (MR) images are scarce. The purpose this study was to develop CNN (DCNN) an optimal accelerating imaging (MRI) acquisition by 6-fold and test quality nonaccelerated versus 15-layer DCNN or 3-layer...
Osteoporosis is one of the complications for patients with rheumatoid arthritis (RA). Rheumatoid cachexia, loss lean body mass, another. However, relationship between decreased mass and reduced bone mineral density (BMD) in RA has not been well studied.This study included 413 participants, comprising 208 205 age- sex-matched healthy volunteers. Clinical data, BMD, metabolic markers (BMM) composition, such as percent fat, were collected. Risk factors osteoporosis including BMD composition...
Abstract Background The dietary inflammatory index (DII®), a quantitative measure of the potential daily food and nutrient intake, associations between variety health outcomes have been reported. However, association DII score disease activity rheumatoid arthritis (RA) is unclear. Therefore, this study was designed to test whether higher contributes as corollary, reducing helps achieve or maintain low remission in patients with RA. Methods We performed cross-sectional longitudinal analysis...
Objectives. The deformed rheumatoid forefoot may be treated with resection of lesser metatarsal heads combined arthrodesis or the first metatarsophalangeal joint. Recurrent hallux valgus deformity has been reported by resection. We performed a prospective, randomized, internal-controlled study to compare results between and Methods. resected bilaterally joint on one side opposite side. investigated 26 patients (52 feet) who were followed at least year. Patients assessed for clinical score,...
Abstract Introduction The effects of biologic and targeted synthetic disease‐modifying anti‐rheumatic drugs (b/tsDMARDs) conventional (csDMARDs) on body composition muscle function in rheumatoid arthritis (RA) patients requiring treatment enhancement were compared. Methods This multicenter, prospective, observational study (PRESENT Study) divided RA non‐randomly into a csDMARD group ( n = 100) b/tsDMARD 100). Changes examined 80 each followed for 52 weeks. percentages new‐onset improved...
Objective. To investigate the correlation between changes in radiological quantitative assessment with clinical and functional from baseline to 3 months patients rheumatoid arthritis (RA). Methods. Twenty-eight RA [methotrexate (MTX) anti-tumor necrosis factor–α (TNF-α) group high disease activity (n = 18); MTX low 10)] underwent assessments at months: [28-joint count Disease Activity Score (DAS28)], [Health Assessment Questionnaire (HAQ) Michigan Hand Outcome (MHQ)], imaging-based [3 Tesla...
Abstract Aim Cardiovascular disease is one of the complications rheumatoid arthritis ( RA ). We researched morbidity and severity existing carotid atherosclerosis plaque associated risk factors in patients with . Method This study included 413 participants, including 208 205 age‐ sex‐matched healthy volunteers. Carotid ultrasound, clinical data collection assessment cardiovascular were performed. Atherosclerotic was defined as an intima‐media thickness ≥ 1.1 mm. Severity assessed by score,...