A5035005369- Dermatology and Skin Diseases
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Tendon Structure and Treatment
- Bone fractures and treatments
- Mesenchymal stem cell research
- Sarcoma Diagnosis and Treatment
- Orthopaedic implants and arthroplasty
- Stress Responses and Cortisol
- Rheumatoid Arthritis Research and Therapies
- Plasma and Flow Control in Aerodynamics
- Plasma Applications and Diagnostics
- Surface Modification and Superhydrophobicity
- Shoulder Injury and Treatment
- Asthma and respiratory diseases
- Spine and Intervertebral Disc Pathology
- Skin Protection and Aging
- Allergic Rhinitis and Sensitization
- Bone health and osteoporosis research
- Exercise and Physiological Responses
- Wound Healing and Treatments
- Bone Tissue Engineering Materials
- Nerve injury and regeneration
Osaka Metropolitan University
2022-2025
Tokyo Metropolitan University
2022-2024
Osaka City University
2010-2022
Search Institute
2018
Kitano Hospital
2018
Adipose-derived stem cells (ADSCs) have anti-inflammatory and regenerative properties. The purpose of this study was to investigate the effect locally administered ADSCs in a rheumatoid arthritis (RA) mouse model. In an vivo experiment, single-cell three dimensionally-cultured ADSC spheroids were injected intra-articularly into knees RA model mice histologically assessed. Marked improvement synovial inflammation articular cartilage regeneration found ADSC-treated mice. Proliferation,...
Background/Objective: Anti-tumor effects of plasma-activated medium (PAM) were demonstrated using various malignant tumors. However, the anti-tumor effect PAM on synovial sarcoma remains unclear. Therefore, we aimed to investigate and its underlying mechanisms, focusing quantitative analyses both intracellular reactive oxygen species (ROS) cell apoptosis. Methods: The human line HS-SY-II was used viability after treatment. We investigated side local injection in a xenograft murine model....
Abstract: To elucidate the possible involvement of nitric oxide (NO) derived from inducible NO synthase (iNOS) in pathogenesis patients with allergic rhinitis, we used an animal model atopic dermatitis (AD) induced by epicutaneous sensitization and analysed differences ear thickness, frequency scratching plasma levels ovalbumin-specific immunoglobulin E (OVA-IgE), transforming growth factor (TGF)-β, tumor necrosis (TNF)-α, adrenocorticotropic hormone (ACTH) α-melanocyte-stimulating (α-MSH)...
Non-thermal atmospheric-pressure plasma (NTAPP) is attracting widespread interest for use in medical applications. The tissue repair capacity of NTAPP has been reported various fields; however, little known about its effect on fracture healing. Non-union or delayed union after a clinical challenge. In this study, we aimed to investigate how irradiation promotes healing non-union model and underlying mechanism, vitro vivo. For the vivo created normal models LEW/SsNSlc rats effects NTAPP. To...
Non-thermal atmospheric-pressure plasma (NTAPP) has been widely studied for clinical applications, e.g., disinfection, wound healing, cancer therapy, hemostasis, and bone regeneration. It is being revealed that the physical chemical actions of have enabled these applications. Based on our previous report regarding plasma-stimulated regeneration, this study focused Achilles tendon repair by NTAPP. This first to reveal exposure NTAPP can accelerate using a well-established injury rat model....
Effects of catecholamines and osmotical physical stimuli on the induction anti-sheep red blood cells (SRBC) plaque-forming (PFC) were investigated in (C57BL/6 X BALB/c)F1 mice vivo vitro. The anti-SRBC PFC from immunized with 5 10(7) SRBC was markedly increased by daily s.c. injections epinephrine. enhancement epinephrine completely blocked preadministration propranolol hexamethonium, but not phentolamine. osmotic given once a day for 4 days after immunization SRBC. these hexamethonium....
Progressive fatty infiltration and muscle atrophy after rotator cuff tears lead to tendon repair failure poor outcomes. Fibro-adipogenic progenitors (FAPs) are involved in homeostasis of skeletal muscle. Inducing FAP differentiation into brown adipocyte-like "beige adipocytes" suppresses atrophy.Parathyroid hormone (PTH) a rat model by browning FAPs.Controlled laboratory study.PTH was administered subcutaneously for 4 or 8 weeks tear rats. After treatment, supraspinatus muscles assessed...
Atopic dermatitis is well known to exacerbate by stress. How the influence of exercise stress on skin symptoms in patients with atopic has not been clarified. The purpose our research investigate how different strength acts dermatitis. Specific pathogen-free (SPF) and conventional NC/Nga male mice were used for experiments. Conventional but SPF group spontaneously develop dermal symptom similar that at their age 7 weeks. They given two types stress, mild (20 m/min 60 min) or strong (25 90...
Abstract Treatment options for metastatic osteosarcoma are limited. The present study aimed to evaluate whether radiofrequency ablation (RFA) combined with intratumoural OK-432 injection induces systemic anti-tumour immunity in rat model. Eighty of 145 rats were assigned four groups overall survival and tumour size: control (no treatment), RFA-only, OK-432, RFA-OK-432. remaining 65 histological examination. Maximum diameters tibial lung tumours determined. Tumour samples histologically...
The stromal-cell-derived factor-1α (SDF-1) is well-known for playing important roles in the regeneration of tissue by enhancing cell migration. However, effect SDF-1 meniscal healing remains unknown. purpose this study to investigate effects intra-articular injection on meniscus a rat defect model. was performed at meniscectomy and one week later. Macroscopic histological assessments reparative were conducted one, two six weeks after rats. In macroscopic evaluation, group showed an increase...
Abstract Ligamentum flavum (LF) hypertrophy is a major cause of lumbar spinal canal stenosis. Although mechanical stress thought to be factor involved in LF hypertrophy, the exact mechanism by which it causes has not yet been fully elucidated. Here, changes gene expression due long‐term were analyzed using RNA‐seq rabbit model. In combination with previously reported analysis results, periostin was identified as molecule whose fluctuates stress. The and function further investigated human...
Biomechanical changes in articular cartilage are associated with the onset of osteoarthritis. We developed an optical coherence tomography-based strain rate tomography method: stress relaxation straingraphy (SR-OCSA). The purpose this study was to establish approach for measuring mechanical properties using SR-OCSA, and investigate distribution viscoelastic early Anterior cruciate ligament transection surgery performed on left knees 8–9-month-old New Zealand white rabbits. SR-OCSA used...
The negative impact of cigarette smoking on bone union has been well documented. However, the heated tobacco product (HTP) use fracture-healing remains unclear. present study investigated effect HTPs preosteoblast viability, osteoblastic differentiation, and compared effects with those conventional combustible cigarettes.Cigarette smoke extracts (CSEs) were generated from cigarettes (cCSE) (hCSE). CSE concentrations standardized by assessing optical density. Preosteoblast (MC3T3-E1) cells...
Medical treatment using non-thermal atmospheric pressure plasma (NTAPP) is rapidly gaining recognition. NTAPP thought to be a new therapeutic method because it could generate highly reactive species in an ambient atmosphere which exposed biological targets (e.g., cells and tissues). If plasma-generated stimulate bone regeneration, can provide opportunity regenerative medicine. Here, we investigated the impact of on regeneration large defect New Zealand White rabbits simple (helium...
Aims Vitamin E-infused highly cross-linked polyethylene (E1) has recently been introduced in total knee arthroplasty (TKA). An vitro wear simulator study showed that E1 reduced wear. However there is no published information regarding vivo Previous reports suggest newly materials which reduce do not necessarily To assist the evaluation of material before widespread use, we established an particle analysis for TKA. The aim this was to compare generation between and conventional (ArCom)...
In modern society, irregular lifestyles are a problem. It is well known that Atopic Dermatitis (AD) occurs during physical stress in people with an lifestyle. We evaluated the influence day-and-night reversal has on AD.Six-week-old specific-pathogen-free and conventional NC/Nga male mice were used. For procedure, ran treadmill at slow speed of 10 m/min for 12 h (between 8:00 20:00). Then, between 20:00 8:00, we put dark place. This treatment was repeated every day two weeks. The behavioral...
Hypertrophy of the ligamentum flavum (LF) is a major cause lumbar spinal stenosis (LSS), and pathology involves disruption elastic fibers, fibrosis with increased cellularity collagens, and/or calcification. Previous studies have implicated expression proteoglycan family in hypertrophied LF. Furthermore, gene profile rabbit experimental model LF hypertrophy revealed that biglycan (BGN) upregulated by mechanical stress. However, function BGN human has not been well elucidated. To investigate...
This study investigated whether mixing low viscosity alginic acid with calcium phosphate cement (CPC) causes interconnected porosity in the CPC and enhances bone replacement by improving biological interactions. Furthermore, we hypothesized that would shorten setting time of improve its strength. samples were prepared 0, 5, 10, 20% acid. After immersion acetate buffer, possible porosification was monitored vitro using scanning electron microscopy (SEM), times compressive strengths measured....