A5101421690- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- RNA modifications and cancer
- Peroxisome Proliferator-Activated Receptors
- Thyroid Cancer Diagnosis and Treatment
- Circular RNAs in diseases
- Alcohol Consumption and Health Effects
- Liver Disease Diagnosis and Treatment
- RNA Research and Splicing
- Thyroid Disorders and Treatments
- Chronic Kidney Disease and Diabetes
- interferon and immune responses
- Toxoplasma gondii Research Studies
- Calpain Protease Function and Regulation
- Cancer-related gene regulation
- Biomarkers in Disease Mechanisms
- Cell death mechanisms and regulation
- Folate and B Vitamins Research
- Vitamin D Research Studies
- Atherosclerosis and Cardiovascular Diseases
- Gout, Hyperuricemia, Uric Acid
- Nutrition and Health in Aging
- Cancer, Lipids, and Metabolism
- Kruppel-like factors research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Huazhong University of Science and Technology
2022-2024
Tongji Hospital
2022-2024
Shanxi Medical University
2008-2023
Shanxi Academy of Medical Sciences
2022-2023
Second Hospital of Shanxi Medical University
2018-2021
Diabetes Foundation
2013
Shanghai Sixth People's Hospital
2013
Shanghai Clinical Research Center
2013
Accumulating clinical evidence suggests that hyperuricemia is associated with an increased risk of type 2 diabetes. However, it still unclear whether elevated levels uric acid can cause direct injury pancreatic β-cells. In this study, we examined the effects on β-cell viability and function. Uric solution or normal saline was administered intraperitoneally to mice daily for 4 weeks. acid-treated exhibited significantly impaired glucose tolerance lower insulin in response challenge than did...
Abstract Hepatic glucose and lipid metabolism disorders promote the development progression of type 2 diabetes mellitus (T2DM), yet underlying mechanisms are not fully understood. Here, we identify tripartite motif-containing protein 21 (TRIM21), a class IV TRIM family member, as pivotal regulator hepatic in T2DM for first time. Bioinformatic analysis suggests that TRIM21 expression is significantly reduced patients. Intriguingly, mouse model obese diabetes, predominantly liver rather than...
The association between thyroid nodules and adiposity remains controversial. We performed a cross-sectional, community-based study to examine whether are associated with overweight obesity, as defined body mass index (BMI) waist circumference.The included 1482 subjects (≥20 years of age; residing in Nanjing, China) receiving questionnaire interview, anthropometric measurements, laboratory tests ultrasonography 2009-2010. Overweight obesity were BMI ≥24 ≥28 kg/m2, respectively. Central was...
Background: Increasing attention has been attracted by the role of circular RNAs (circRNAs) in ocular diseases. Previous study revealed that circ_0005941 (also known as circFTO, an alpha-ketoglutarate–dependent dioxygenase) was upregulated vitreous humor diabetic retinopathy (DR), while its underlying mechanism DR remains unknown. Methods: Retinal vascular endothelial cells (RVECs) treated with high glucose (HG) were used to establish cell model. The vivo assays conducted using...
Triple-negative breast cancer (TNBC) is a common with increasing incidence and mortality in female. Increasing studies have revealed that long noncoding RNAs (lncRNAs) are novel molecules regulating tumors. Long intergenic non-protein coding RNA 1234 (LINC01234) has been demonstrated to function as an oncogene several However, the role of LINC01234 TNBC remains unelucidated. Herein, RT-qPCR showed expression was upregulated both tissues cell lines. Functionally, knockdown suppressed...
Alcoholic beverages are widely consumed all over the world, but continuous ethanol exposure leads to hepatic steatosis that, without proper treatment, will later develop into severe liver disorders. In this study, we investigated potential protective effect of tangeretin, a flavonoid derived from citrus peel, against alcoholic fatty liver. The in vivo effects tangeretin were analyzed by oral intake chronic-binge alcohol feeding C57BL/6j mouse model, while underlying mechanism was explored...
Abstract Background In recent years, long non-coding RNAs (lncRNAs) have attracted much attention because of its regulatory role in occurrence and progression tumors, including triple-negative breast cancer (TNBC). LncRNA PITPNA antisense RNA 1 (PITPNA-AS1) has been explored some cancers, whereas function molecular mechanism TNBC remain unclear. Methods PITPNA-AS1 expression tissues cells was determined by RT-qPCR. cell viability, proliferation, migration, invasion were assessed with CCK-8,...
Diabetic retinopathy (DR) as a frequent diabetic microvascular complication shows signs in one-third of patients. Long non-coding RNAs (lncRNAs) have drawn increasing attention because their regulatory roles DR. LncRNA plasmacytoma variant translocation 1 (PVT1) is documented to be upregulated diabetes-related diseases, while its effects DR remains unexplored. ARPE-19 cells under the treatment high-glucose (HG) were used cell models. The gene expression was examined using RT-qPCR. viability...
Metabolic reprogramming is one of the cancer hallmarks, important for survival malignant cells. We investigated prognostic value genes associated with metabolism in thyroid carcinoma (THCA). A risk model metabolism-related (MRGs) was built and tested based on datasets The Cancer Genome Atlas (TCGA), univariate Cox regression analysis, LASSO, multivariate analysis. used Kaplan-Meier (KM) curves, time-dependent receiver operating characteristic curves (ROC), a nomogram, concordance index...
Prostate adenocarcinoma (PRAD) persists as the predominant non-cutaneous malignancy diagnosed in males, which is a primary contributor to cancer-related mortality globally. It reported that progression of prostate associated with various factors, including genetics, age, obesity, etc. Contemporary research indicates epigenetic inheritance leading factor initiation and cancer. RNA methylation modification most prevalent form modification, N6-methyladenosine (m6A) representing common on mRNA...
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | 1479-6848 (online)
Objective To investigate the effect on growth and development of fetus placental coefficient BALB/c mice infected with Toxoplasma gondii during second trimester pregnancy. Me-thods The animal model was established by intraperitoneal injection ( i. p. ) tachyzoites T. at 8th day pregnancy, then placentas fetuses were separated 12th, 14th,16th, 18th respectively. survival rate observed under anatomical micro-scope, weighted electronic balance, body length tail measured sliding caliper. Results...