A5030396238- Urinary Bladder and Prostate Research
- Bladder and Urothelial Cancer Treatments
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Dermatology and Skin Diseases
- Pelvic floor disorders treatments
- Urinary Tract Infections Management
- Urological Disorders and Treatments
- Sexual function and dysfunction studies
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Neuroinflammation and Neurodegeneration Mechanisms
- Kidney Stones and Urolithiasis Treatments
- Healthcare and Venom Research
- Ion Channels and Receptors
- Cancer, Lipids, and Metabolism
- Ubiquitin and proteasome pathways
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Ureteral procedures and complications
- Pediatric Urology and Nephrology Studies
- Endometriosis Research and Treatment
- IgG4-Related and Inflammatory Diseases
- Neuroendocrine Tumor Research Advances
- COVID-19 and Mental Health
University of South China
2019-2025
Third Affiliated Hospital of Sun Yat-sen University
2014-2025
Sun Yat-sen University
2014-2025
Xiangya Hospital Central South University
2023-2024
Central South University
2023-2024
First Affiliated Hospital of University of South China
2019-2024
The University of Texas Medical Branch at Galveston
2016-2022
China National Center for Food Safety Risk Assessment
2016
Adrenomedullin (ADM) exerts anti-oxidant, anti-inflammatory and anti-apoptotic effects in Leydig cells. However, the role mechanism of ADM pyroptosis cells are poorly understood. This study first showed protective on biological functions exposed to lipopolysaccharide (LPS) by promoting autophagy. Primary rat were treated with various concentrations LPS ADM, together or without N-acetyl-L-cysteine (NAC) 3-methyladenine (3-MA). Cell proliferation was detected through CCK-8 BrdU incorporation...
Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) often grieve over a low quality of life brought about by chronic pain. In our previous studies, we determined that neuroinflammation the spinal dorsal horn (SDH) was associated mechanisms cystitis. Moreover, it has been shown brain-derived neurotrophic factor (BDNF) participates in regulation and pathological through BDNF-TrkB signaling; however, whether plays role cyclophosphamide (CYP)-induced cystitis remains unclear. This...
<b><i>Objectives:</i></b> Although evidence supports a role for inflammation in interstitial cystitis/bladder pain syndrome (IC/BPS), the mechanism remains unknown. We determined whether causes an elevated expression of nerve growth factor (NGF) and transient receptor potential vanilloid subtype 1 (TRPV1) correlated them with symptoms. <b><i>Methods:</i></b> Bladder biopsies were obtained from 53 IC/BPS patients 27 controls, hematoxylin eosin...
Abstract Background Bladder-related pain symptoms in patients with bladder syndrome/interstitial cystitis (BPS/IC) are often accompanied by depression and memory deficits. Magnesium deficiency contributes to neuroinflammation is associated pain, depression, Neuroinflammation involved the mechanical allodynia of cyclophosphamide (CYP)-induced cystitis. Magnesium-L-Threonate (L-TAMS) supplementation can attenuate neuroinflammation. This study aimed determine whether how L-TAMS influences...
The long non-coding RNA (lncRNA) AGAP2-AS1 was implicated in tumorigenesis, yet with unclear mechanism the development of Bladder Cancer (BCa).We collected clinicopathological features and tissue samples 45 patients BCa Xiangya Hospital. Expressions LRG1 were detected by RT-qPCR tissues normal as well cells. roles investigated CCK-8, colony formation assay, transwell assays tube assay. subcellular localization Fluorescence situ hybridization. Bioinformatics method, immunoprecipitation,...
Central sensitization plays a critical role in bladder pain syndrome/interstitial cystitis (BPS/IC). Electroacupuncture (EA) nerve stimulation therapy has been broadly acknowledged as an effective means of alleviating chronic pathological pain. However, it remains to be explored whether EA is mitigating pain-sensitive symptoms BPS/IC and the mechanisms involved. This study aims investigate analgesic effect mechanism therapy. To achieve this goal, we employed several techniques: mechanical...
Background Previous studies have demonstrated that glial cells play an important role in the generation and maintenance of neuropathic pain. Activated produce numerous mediators such as proinflammatory cytokines facilitate neuronal activity synaptic plasticity. Similarly, bladder pain syndrome/interstitial cystitis shares many characteristics However, related report on involvement spinal glia cystitis-associated pathological underlying mechanisms are still lacking. The present study...
Bladder cancer (BC) is a commonly occurring malignant tumor of the urinary system, demonstrating high global morbidity and mortality rates. BC currently lacks widely accepted biomarkers its predictive, preventive, personalized medicine (PPPM) still unsatisfactory. N6-methyladenosine (m6A) modification non-coding RNAs (ncRNAs) have been shown to be effective prognostic immunotherapeutic responsiveness contribute PPPM for various tumors. However, their role in remains unclear. m6A-related...
Abstract Opioids are the frontline analgesics in pain management. However, chronic use of opioid causes paradoxical that contributes to decrease their efficacy control and escalation dose long-term management pain. The underling pathogenic mechanism is not well understood. Microglia have been commonly believed play a critical role expression opioid-induced hyperalgesia animal models. We performed microglial ablation experiments using either genetic (CD11b-diphtheria toxin receptor transgenic...
To investigate the relationship between surgeon's experience, tumor characteristics, absent detrusor muscle (DM) tissue in resected specimens, and residual after an initial transurethral resection.We conducted analysis of 216 patients from two centers over a 3-year period. Patients with primary bladder tumors that were judged to have been completely recruited. The data included surgeon category, DM status. Logistic regression multivariate analyses conducted.Large tumors,...
Abstract Background In recent years, long non-coding RNAs (lncRNAs) have attracted much attention because of its regulatory role in occurrence and progression tumors, including triple-negative breast cancer (TNBC). LncRNA PITPNA antisense RNA 1 (PITPNA-AS1) has been explored some cancers, whereas function molecular mechanism TNBC remain unclear. Methods PITPNA-AS1 expression tissues cells was determined by RT-qPCR. cell viability, proliferation, migration, invasion were assessed with CCK-8,...
The mechanism of interstitial cystitis/bladder pain syndrome (IC/BPS) remains unclear to date, but reports showed that bladder inflammation and increasing number activating mast cells in tissues were common patients with IC/BPS. Houttuynia cordata is widely used Chinese traditional medicine, its function anti-inflammation has been proved. purpose this study was investigate the efficacy possible mechanisms (HC) extract treatment (IC/BPS). In current study, a total 30 adult female rats...
There are currently no studies exploring omicron infection and male sexual function semen quality. Our aim was to estimate changes in quality men recovering from since the COVID-19 Omicron pandemic started China late 2022. We collected 1540 questionnaires assessed before acute phase after by using International Index of Erectile Function-5, Premature Ejaculation Diagnostic Tool, Arizona Sexual Experience Scale. also analysis results 247 patients. During infection, proportion erectile...
Pine nut (Pinus koraiensis) meal protein peptides (PNMPP), a kind of Korean pine seed oil by-products, were often considered as waste disposal in food industry. In the present study, we found that 3–10 kDa PNMPP could enhance immunity ICR mice at 100 mg·(kg·d)−1 both innate and adaptive immunity. immunity, abdominal macrophage phagocytosis 30.22% index carbon clearance significantly (P < .05). addition, out low dose cytokine interferon-γ, interleukin-2, interleukin-4, interleukin-6...
Bladder pain syndrome/interstitial cystitis (BPS/IC) is a refractory disease accompanied by bladder-related and hyperactivity. Studies have shown that the translocator protein (TSPO) modulates neuroinflammation central sensitisation associated with pain. Moreover, we previously demonstrated brain-derived neurotrophic factor (BDNF) regulates mechanical allodynia in cyclophosphamide (CYP)-induced through activation of glial cells. Here, aimed to explore whether TSPO attenuates bladder...