A5058740290- Pain Mechanisms and Treatments
- Anesthesia and Neurotoxicity Research
- Anesthesia and Sedative Agents
- Neuroscience and Neuropharmacology Research
- Anesthesia and Pain Management
- Ion channel regulation and function
- Osteoarthritis Treatment and Mechanisms
- Neuropeptides and Animal Physiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related molecular mechanisms research
- Adenosine and Purinergic Signaling
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- Cardiac Ischemia and Reperfusion
- Obsessive-Compulsive Spectrum Disorders
- Intensive Care Unit Cognitive Disorders
- Cancer, Stress, Anesthesia, and Immune Response
- Ion Channels and Receptors
- Laser Applications in Dentistry and Medicine
- 3D IC and TSV technologies
- Neuroendocrine regulation and behavior
- Photoreceptor and optogenetics research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cardiac, Anesthesia and Surgical Outcomes
- Electromagnetic Compatibility and Noise Suppression
Sichuan University
2016-2025
West China Hospital of Sichuan University
2016-2025
Guangdong University of Technology
2025
Central South University
2013-2024
First Affiliated Hospital of Jinan University
2024
Xiangya Hospital Central South University
2022-2024
Hangzhou Hospital of Traditional Chinese Medicine
2024
Changzhou No.2 People's Hospital
2020-2024
Nanjing Traditional Chinese Medicine Hospital
2024
Chengdu University
2023
Abstract Background: Ketamine is a commonly used anesthetic, but the mechanistic basis for its clinically relevant actions remains to be determined. The authors previously showed that HCN1 channels are inhibited by ketamine and demonstrated global knockout mice twofold less sensitive hypnotic of ketamine. Although work identified as viable molecular target ketamine, it did not determine neural substrate. Methods: To localize brain region responsible HCN1-mediated conditional strategy delete...
In this paper, we proposed for the first time a novel mechanism to design tri-band low-scattering metasurface. The radar cross section (RCS) reduction in three operational bands relies on scattering diffusion, absorption, and cancellation, respectively. diffusion metasurface was realized by distributing unit cells with different rotation angles. For four units operating at frequencies were combined achieve broadband absorption. cancellation arranging two out of phase elements chessboard...
Abstract: Intraoperative Neurophysiological Monitoring (IONM) is an indispensable surgical tool that offers invaluable insights into neurological function across a spectrum of anatomical areas. By comprehensively assessing the integrity brain, brainstem, spinal cord, cranial nerves, and peripheral IONM plays pivotal role in guiding decision-making optimizing patient outcomes, particularly context high-risk procedures. drugs, especially anesthetics and/or analgesics, differentially modulate...
The main shaft seal of offshore wind power equipment is one the key components systems. However, wear issues between seals and caused by intrusion particulate matter in environment have become a factor affecting service life equipment. To improve surface performance shaft, this study used laser cladding technology to prepare an Fe55 coating on QT-500 components. Through experiments HNBR pairs with under different load conditions, thoroughly investigated impact frictional coefficients,...
Kainate receptors (KARs), along with AMPA and NMDA receptors, belong to the ionotropic glutamate receptor (iGluR) family play critical roles in mediating excitatory neurotransmission throughout central nervous system. KARs also regulate neurotransmitter release modulate neuronal excitability plasticity. Receptor desensitization plays a role modulating strength of synaptic transmission While share overall structural similarity desensitized state differs strikingly from that other iGluRs....
Hyperpolarization-activated, cyclic nucleotide-gated (HCN) subtype 1 (HCN1) channels have been identified as targets of ketamine to produce hypnosis. Volatile anesthetics also inhibit HCN1 channels. However, the effects on volatile in vivo are still elusive. This study uses global and conditional knockout mice evaluate how affect actions anesthetics.Minimum alveolar concentrations (MACs) isoflurane sevoflurane that induced immobility (MAC immobility) and/or hypnosis hypnosis) were determined...
Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus, there is a need to develop new reparative therapies. In that regard, stimulating tissue regeneration by autologous stem/progenitor cells has emerged as promising strategy. We showed previously migratory chondrogenic progenitor (CPCs) were recruited injured cartilage, where they capability in situ repair. Here, we tested hypothesis contains similar population of regenerative cells. Explant studies...
Abstract Impaired response inhibition has been consistently reported in patients diagnosed with obsessive-compulsive disorder (OCD). This clinically heterogeneous is characterized by several symptom dimensions that may have distinct, but partially overlapping, neural correlates. The present study examined whether alterations be related to severity and dimensions. Event-related potentials (ERPs) were recorded a group of 42 medication-free OCD as well healthy controls during stop-signal task....
Abstract Inflammatory orofacial pain, in which substance P (SP) plays an important role, is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs). SGC activation emerging as key mechanism underlying inflammatory pain through different signalling mechanisms, including fibrillary acidic protein (GFAP) activation, phosphorylation of mitogen-activated kinase (MAPK) pathways, cytokine upregulation. However, TG, SP-mediated generated by SGCs...
Abstract Satellite glial cells (SGCs) activation in the trigeminal ganglia (TG) is critical various abnormal orofacial sensation nerve injury and inflammatory conditions. SGCs express several subtypes of P2 purinergic receptors contributing to initiation maintenance neuropathic pain. The P2Y 14 receptor, a G‐protein‐coupled receptor activated by uridine diphosphate (UDP)‐glucose other UDP sugars, mediates physiologic events such as immune, inflammation, However, expression, distribution,...
Volatile anesthetics induce hyperactivity during induction while producing anesthesia at higher concentrations. They also bidirectionally modulate many neuronal functions. However, the mechanism is unclear. The effects of isoflurane on sodium channel currents were analyzed in acute mouse brain slices, including leak (NALCN) and voltage-gated channels (Nav) currents. Isoflurane sub-anesthetic concentrations increased spontaneous firing rate CA3 pyramidal neurons, whereas anesthetic decreased...
ABSTRACT We showed previously that chondrogenic progenitor cells (CPCs) from the superficial zone of articular cartilage respond vigorously to wounding by responding chemotactically cell debris, but physiologic functions CPCs remain unclear. To help bridge this knowledge gap we undertook a comparative analysis gene expression in bovine CPCs, chondrocytes, synovial fibroblasts (synoviocytes), and isolated fluid (SFCs). Analysis microarrays parsed four types into two distinct groups, one...
Power line communication (PLC) provides intelligent electrical functions such as power quality measurement, fault surveys, and remote control of network. Most research works have been done in low voltage (LV) scenario due to the fast development in-home PLC. The aim this paper is evaluate link-level performance a medium (MV) MIMO-OFDM system based on transmission link under underground channel. MIMO channel modeled modified multipath model presence impulsive noise background noise. We first...
Background Volatile anesthetics moderately depress respiratory function at clinically relevant concentrations. Phox2b-expressing chemosensitive neurons in the retrotrapezoid nucleus, a control center, are activated by isoflurane, but underlying mechanisms remain unclear. The hypothesis of this study was that sodium leak channel contributes to volatile anesthetics-induced modulation nucleus and output. Methods contribution channels isoflurane-, sevoflurane-, propofol-evoked activity output...