A5055560998- Ultrasound and Hyperthermia Applications
- Osteoarthritis Treatment and Mechanisms
- Infrared Thermography in Medicine
- Knee injuries and reconstruction techniques
- Cellular Mechanics and Interactions
- Heart Rate Variability and Autonomic Control
- Tendon Structure and Treatment
- Cardiac Structural Anomalies and Repair
- Periodontal Regeneration and Treatments
- Advanced Drug Delivery Systems
- EEG and Brain-Computer Interfaces
- Cardiac Fibrosis and Remodeling
- Cardiac Imaging and Diagnostics
- Bone Tumor Diagnosis and Treatments
- Microbial Inactivation Methods
- Musculoskeletal synovial abnormalities and treatments
- Ultrasound in Clinical Applications
- Nanoparticle-Based Drug Delivery
- Photoacoustic and Ultrasonic Imaging
- Elasticity and Material Modeling
- NF-κB Signaling Pathways
- Cell Adhesion Molecules Research
- Vagus Nerve Stimulation Research
- Cardiovascular Function and Risk Factors
- Healthcare and Venom Research
Center for Devices and Radiological Health
2020
United States Food and Drug Administration
2020
Office of Science
2020
National Institutes of Health
2016-2020
National Institutes of Health Clinical Center
2016-2018
University of Iowa
2013-2015
Serious meniscus injuries seldom heal and increase the risk for knee osteoarthritis; thus, there is a need to develop new reparative therapies. In that regard, stimulating tissue regeneration by autologous stem/progenitor cells has emerged as promising strategy. We showed previously migratory chondrogenic progenitor (CPCs) were recruited injured cartilage, where they capability in situ repair. Here, we tested hypothesis contains similar population of regenerative cells. Explant studies...
Focal adhesions are transmembrane protein complexes that attach chondrocytes to the pericellular cartilage matrix and in turn, linked intracellular organelles via cytoskeleton. We previously found excessive compression of articular leads cytoskeleton-dependent chondrocyte death. Here we tested hypothesis this process also requires integrin activation signaling focal adhesion kinase (FAK) Src family (SFK). Osteochondral explants were treated with FAK SFK inhibitors (FAKi, SFKi, respectively)...
Background: Investigations into the benefits of Vagus nerve stimulation (VNS) through clinical and pre-clinical research have led to promising findings for treating several disorders. Despite proven efficacy VNS on approved conditions such as epilepsy depression, underlying mechanism off-target effects contribution factors sex differences can be beneficial optimize design therapy. New methods: In this paper, we assessed longitudinal cardiovascular immune systems potential using rat models...
Image-guided high intensity focused ultrasound has been used as an extracorporeal cardiac pacing tool and to enhance homing of stem cells targeted tissues. However, molecular changes in the myocardium after sonication have not widely investigated. Magnetic-resonance (MR)-guided pulsed (pFUS) was rat over a range pressures microenvironmental histological effects were evaluated time. Eight-to-ten-week-old Sprague–Dawley rats received T2-weighted MR images target pFUS left ventricular septum...
Melanoma is one of the most aggressive types cancer, and its incidence has increased rapidly in past few decades. In this study, we investigated a novel treatment approach, use low-intensity ultrasound (2.3 W/cm2 at 1 MHz)-mediated Optison microbubble (MB) destruction (UMMD) to treat melanoma flank tumor model. The effect UMMD was first evaluated cell line B16 F10 (B16) vitro then mice inoculated with cells. MB+B16 cells were exposed US vitro, resulting significant death proportional duty...
Background: Transplantation of osteochondral allografts (OCAs) freshly preserved for ≥30 days has proven to be a reliable technique cartilage resurfacing. However, the prolonged storage comes at expense chondrocyte viability, which declines precipitously after 14 under refrigeration. Despite this, radiographic data indicate that most allograft remains stable years implantation. The apparent durability partially devitalized begs question how extracellular matrix is maintained. Hypothesis:...
Abstract Image‐guided pulsed focused ultrasound (pFUS) is a non‐invasive technique that can increase tropism of intravenously (IV)‐infused mesenchymal stromal cells (MSC) to sonicated tissues. MSC have shown promise for cardiac regenerative medicine strategies but be hampered by inefficient homing the myocardium. This study left ventricles (LV) in rats with magnetic resonance imaging (MRI)‐guided pFUS and examined both proteomic responses subsequent treated T2‐weighted MRI was used targeting...