A5103187122- Anesthesia and Neurotoxicity Research
- Cardiac Ischemia and Reperfusion
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Anesthesia and Sedative Agents
- Cardiac Fibrosis and Remodeling
- Autophagy in Disease and Therapy
- Pregnancy and preeclampsia studies
- Pancreatic function and diabetes
- Inflammasome and immune disorders
- Endoplasmic Reticulum Stress and Disease
- Cardiac electrophysiology and arrhythmias
- Birth, Development, and Health
- Fuel Cells and Related Materials
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Gynecological conditions and treatments
- Trigeminal Neuralgia and Treatments
- Diabetes Treatment and Management
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Biochemical effects in animals
- Gestational Diabetes Research and Management
- Alzheimer's disease research and treatments
- Pregnancy and Medication Impact
- Selenium in Biological Systems
Shanghai First People's Hospital
2018-2024
Shanghai Jiao Tong University
2018-2024
Shanghai Xuhui Central Hospital
2019-2021
Hangzhou First People's Hospital
2012-2018
Sir Run Run Shaw Hospital
2014-2018
Zhejiang University
2014-2018
Shanghai Tenth People's Hospital
2017-2018
Tongji University
2017-2018
Hangzhou Medical College
2017
Fudan University
2016-2017
Diabetes mellitus is a significant global public health problem depicting rising prevalence worldwide. As serious complication of diabetes, diabetes-associated cognitive decline attracting increasing attention. However, the underlying mechanisms are yet to be fully determined. Both endoplasmic reticulum (ER) stress and autophagy have been reported modulate neuronal survival death associated with several neurodegenerative diseases. Here, streptozotocin-induced diabetic mouse model primary...
Lipotoxicity has been implicated in pancreatic β-cell dysfunction type 2 diabetes, but the exact mechanisms remain unknown. The current study explored role of endoplasmic reticulum (ER) stress pathway cholesterol-induced lipotoxicity. Two different insulinoma cell lines were treated with cholesterol or without inhibitors. ER stress-associated proteins glucose-regulated protein (GRP) 78, activating transcription factor (ATF) 4 and C/EBP homologous (CHOP), as was phosphorylation eukaryotic...
Postoperative cognitive dysfunction (POCD) is a clinical phenomenon characterized by deficits in patients after anesthesia and surgery, especially geriatric surgical patients. Although it has been documented that isoflurane exposure impaired function several aged animal models, there are few interventions treatments available to prevent this disorder. Minocycline well established exert neuroprotective effects various experimental models neurodegenerative diseases. Therefore, we hypothesized...
Pathological cardiac hypertrophy aggravated myocardial infarction and is causally related to autophagy dysfunction increased oxidative stress. Rapamycin an inhibitor of serine/threonine kinase mammalian target rapamycin (mTOR) involved in the regulation as well oxidative/nitrative Here, we demonstrated that ameliorates ischaemia reperfusion injury by rescuing defective cytoprotective mechanisms hypertrophic heart. Our results showed chronic treatment markedly reduced phosphorylated mTOR...
Abstract Background Ischaemic preconditioning elicited by brief periods of coronary occlusion and reperfusion protects the heart from a subsequent prolonged ischaemic insult. Here, we test hypothesis that short‐term non‐ischaemic stimulation hypertrophy renders resistant to injury. Methods Results Transient transverse aortic constriction (TAC) was performed for 3 days in mice then withdrawn 4 debanding, followed exposure myocardial ischaemia‐reperfusion (I/R) Following I/R injury, infarct...
Remote ischemic preconditioning (RIPC) is one of the most powerful intrinsic cardioprotective strategies discovered so far and experimental data indicate that comorbidity may interfere with protection by RIPC. Therefore, we investigate whether RIPC-induced cardioprotection was intact in hypercholesterolemic rat hearts exposed to ischemia reperfusion vivo. Normal or were 30 min 2 h reperfusion, without RIPC, PI3K inhibitor wortmannin, MEK-ERK1/2 PD98059, GSK3β SB216763. Infarct size,...
The mechanisms underlying cyclin-dependent kinase 5 (Cdk5)-mediated thermal hyperalgesia induced by inflammation remain poorly understood. In the present study, we examined provoked peripheral injection of complete Freund׳s adjuvant (CFA) to test for Cdk5 signaling in spinal dorsal horns rats through p38 mitogen-activated protein (p38 MAPK) pathway, which is known function mediating inflammatory pain.We pain model plantar CFA and compared inhibitory effects roscovitine SB203580 on...
Introduction: Gestational diabetes mellitus (GDM) is a metabolic disorder during mid- to late-pregnancy characterized by hyperglycemia, insulin resistance and fetal mal-development. Glucose transporter type 2 (GLUT2) sodium-coupled glucose cotransporters (SGLT2) in the proximal tubules play critical role reabsorption of have been linked occurrence (T2DM). Our study was designed investigate GLUT2 SGLT2 pathogenesis GDM, which considered forerunner T2DM, related molecular mechanism. Methods:...
Relative expression of IR, IRS-1, IRS-2 and GLUT4 mRNA was determined in insulin-resistant 3T3-L1 adipocytes with different treatments.
Recent studies have demonstrated that volatile anesthetic postconditioning confers myocardial protection against ischemia-reperfusion injury through activation of the reperfusion salvage kinase (RISK) pathway. As RISK has been shown to be impaired by ventricular hypertrophy, we investigate whether anesthetic-induced cardiac was maintained in rat hearts with hypertrophy. Transverse aortic constriction operation performed on male Sprague-Dawley rats induce left (LV) then sham-operated or...
The transverse aortic constriction (TAC) model surgery is a widely used disease to study pressure overload–induced cardiac hypertrophy and heart failure in mice. severity of adverse remodeling the TAC largely dependent on degree around aorta, phenotypes are also different mouse strains. Few studies focus directly comparing with degrees no compares difference C57BL/6N In present study, mice aged 10 weeks were subjected sham, 25G TAC, 26G 27G for 4 weeks. We then analyzed induced by c57BL/6N...
Left ventricular hypertrophy (LVH) is causally related to increased morbidity and mortality following acute myocardial infarction (AMI) via still unknown mechanisms. Although rapamycin exerts cardioprotective effects against ischemia/reperfusion (MI/R) injury in normal animals, whether rapamycin-elicited cardioprotection altered the presence of LVH has yet be determined. Pressure overload induced cardiac hypertrophied mice sham-operated controls were exposed AMI by coronary artery ligation,...
Recent studies have demonstrated that intralipid (ILP) conferred myocardial protection against ischemia-reperfusion (IR) injury through activation of reperfusion salvage kinase (RISK) pathway. As RISK signal has been shown to be impaired in hypertrophied myocardium, we investigated whether ILP-induced cardiac was maintained rat hearts. Transverse aortic constriction performed on male Sprague-Dawley rats induce left ventricular hypertrophy, then sham-operated or hearts were isolated and...