A5089557712- Pain Mechanisms and Treatments
- Spinal Cord Injury Research
- Hepatitis C virus research
- HIV/AIDS drug development and treatment
- Musculoskeletal pain and rehabilitation
- Nerve injury and regeneration
- Transcranial Magnetic Stimulation Studies
- Neuroscience of respiration and sleep
- Neuroendocrine regulation and behavior
- Zebrafish Biomedical Research Applications
- Pain Management and Placebo Effect
- Ion channel regulation and function
- Pediatric Pain Management Techniques
- Stress Responses and Cortisol
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Spine and Intervertebral Disc Pathology
- Systemic Lupus Erythematosus Research
- Anesthesia and Pain Management
- Neurogenetic and Muscular Disorders Research
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Liver Disease Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Parvovirus B19 Infection Studies
AbbVie (United States)
2019-2021
The University of Texas Medical Branch at Galveston
2004-2012
Abbott (United States)
2012
Merck (Japan)
2008
United States Military Academy
2007-2008
In-Q-Tel
2008
University of California, Los Angeles
2007
Galveston College
2007
Texas A&M University
1999-2005
Safe and effective treatment for chronic inflammatory neuropathic pain remains a key unmet medical need many patients. The recent discovery description of the transient receptor potential family receptors including TRPV1 TRPA1 has provided number new therapeutic targets treating pain. Recent reports have suggested that may play an important role in acute formalin CFA induced current study was designed to further explore pharmacological antagonism treat pain.The vitro potencies HC-030031...
•Meta-analysis of real-world data from 12,583 patients taking glecaprevir/pibrentasvir.•Glecaprevir/pibrentasvir achieved 96.7% virologic cure overall.•Virologic was ≥95% across subgroups interest.•Serious adverse events were reported in 1.0% patients.•Effectiveness and safety results consistent with those clinical trials. Background & AimsGlecaprevir/pibrentasvir is approved for treating adults infected HCV genotypes 1–6. In trials, glecaprevir/pibrentasvir associated high rates sustained...
Although recovery from spinal cord injury is generally meager, evidence suggests that step training can improve stepping performance, particularly after neonatal injury. The location and nature of the changes in neural substrates underlying behavioral improvements are not well understood. We examined kinematics performance cellular synaptic electrophysiological parameters ankle extensor motoneurons nontrained treadmill-trained rats, all receiving a complete transection as neonates. For...
In this study, we evaluated whether propentofylline, a methylxanthine derivative, modulates spinal glial activation and GABAergic inhibitory tone by modulation of glutamic acid decarboxylase (GAD)(65), the GABA synthase enzyme, in dorsal horn following cord injury (SCI). Sprague-Dawley rats (225-250 g) were given unilateral transverse injury, from to ventral, at T13 segment. Unilateral injured developed robust bilateral hindlimb mechanical allodynia hyperexcitability wide dynamic range (WDR)...
Synaptic plasticity within the spinal cord has great potential to facilitate recovery of function after injury (SCI). Spinal can be induced in an activity-dependent manner even without input from brain complete SCI. A mechanistic basis for these effects is provided by research demonstrating that synapses have many same mechanisms are known underlie learning and memory brain. In addition, lumbar sustain several forms memory, including limb-position training. However, not all promotes...
Prior studies have shown that neurons within the spinal cord are sensitive to response-outcome relations, a form of instrumental learning. Spinally transected rats receive shock one hind leg learn maintain in flexed position minimizes net exposure (controllable shock). uncontrollable stimulation (intermittent shock) inhibits this spinally mediated Here it is undermines recovery function after contusion injury. Rats received moderate injury (12.5 mm drop) and was monitored for 6 weeks. In...
Summary Activated neuronal CaMKII is a critical component of the intracellular signaling pathways that contribute to neuropathic pain and persistent hyperexcitability after spinal cord injury. Chronic central nervous system injuries remains refractory therapeutic interventions. A novel approach would be target key proteins are known continued activation by phosphorylation kinases, transcription factors, and/or receptors changes in membrane excitability. We demonstrate one kinase,...
Spinalized rats given shock whenever 1 hind leg is extended learn to maintain that in a flexed position, simple form of instrumental learning. Rats independent position do not exhibit an increase flexion duration. Experiment showed 6 min intermittent legshock can produce this deficit. Intermittent tailshock undermines learning (Experiments 2-3), and effect lasts at least 2 days (Experiment 4). Exposure continuous did induce deficit 5) but antinociception 6). 7 addressed alternative...
How nociceptive signals are processed within the spinal cord, and whether these lead to behavioral signs of neuropathic pain, depends upon their relation other events behavior. Our work shows that relations can have a lasting effect on plasticity, inducing form learning alters subsequent stimuli. The capacity lower systems adapt, in absence brain input, is examined spinally transected rats receive shock tibialis anterior muscle one hind leg. If delivered whenever leg extended (controllable...
Rats exposed to a few moderately intense (1 mA) shocks subsequently exhibit lower vocalization thresholds shock and thermal stimuli. They also facilitated learning in Pavlovian conditioning paradigm. Together, these results suggest that exposure can enhance pain (hyperalgesia). The present study examined the role of amygdala bed nucleus stria terminalis (BNST), 2 systems have been implicated induction maintenance negative affective states. Experiment 1 showed lesions central, but not...
We have shown that spinal cord neurons can support a simple form of instrumental learning. In typical experiment, rats are spinalized at the second thoracic vertebra (T 2 ) and given shock to one hindleg. One group (master) receives whenever leg is extended. This response-contingent causes an increase in response duration decreases net exposure. learning not observed yoked controls receive same amount independent position (noncontingent shock). Interestingly, received noncontingent also fail...
The spinal cord demonstrates several forms of plasticity that resemble brain-dependent learning and memory. Among the most studied form is memory for noxious (nociceptive) stimulation. Numerous papers have described central pain as a spinally-stored enhances future responses to cutaneous This phenomenon, known sensitization, has broad relevance range pathological conditions. Work from injury (SCI) field indicates lumbar other plasticity, including formal After complete thoracic SCI, can be...
Abstract Although direct‐acting antivirals (DAAs) for chronic hepatitis C virus (HCV) infection are highly efficacious and safe, treatment initiation is often limited in patients with neuropsychiatric disorders due to concerns over reduced adherence drug–drug interactions. Here, we report adherence, efficacy, safety patient‐reported outcomes (PROs) from an integrated analysis of registrational studies using the pangenotypic DAA regimen glecaprevir pibrentasvir (G/P). Patients HCV genotypes...