A5043715347- Treatment of Major Depression
- Mental Health Research Topics
- Soft tissue tumors and treatment
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Digital Mental Health Interventions
- Stress Responses and Cortisol
- Online and Blended Learning
- Teacher Education and Leadership Studies
- Education and Critical Thinking Development
- COVID-19 and Mental Health
- Child and Adolescent Psychosocial and Emotional Development
- Health Systems, Economic Evaluations, Quality of Life
- Interprofessional Education and Collaboration
- Bipolar Disorder and Treatment
- DNA Repair Mechanisms
- Health, psychology, and well-being
- Gut microbiota and health
- Teacher Professional Development and Motivation
- Nonmelanoma Skin Cancer Studies
- COVID-19 Clinical Research Studies
- Diversity and Career in Medicine
- Hepatitis C virus research
- Impact of Technology on Adolescents
Stanford University
2022-2024
The University of Texas Southwestern Medical Center
2022-2024
Albert Einstein College of Medicine
2013-2023
University of Toronto
2018-2023
AbbVie (United States)
2014-2023
Hospital for Sick Children
2023
Geriatric Research Education and Clinical Center
2023
RELX Group (United States)
2023
Northeast Ohio Medical University
2023
Emory University
2023
Chaperone-mediated autophagy (CMA) is activated in response to cellular stressors prevent proteotoxicity through selective degradation of altered proteins lysosomes. Reduced CMA activity contributes the decrease proteome quality disease and ageing. Here, we report that also upregulated genotoxic insults declined functionality leads reduced cell survival genomic instability. This role genome control exerted regulated checkpoint kinase 1 (Chk1) by this pathway after insult. Nuclear...
Background: Anhedonia is a common, persistent, and disabling phenomenon in treated adults with Major Depressive Disorder (MDD). Hitherto, relatively few antidepressant agents have been evaluated respect to their effect on anhedonia MDD. Methods: This post-hoc analysis of primary study that sought evaluate the sensitivity change THINC-integrated tool (THINC-it) MDD (ClinicalTrials.gov Identifier: NCT03053362). Adults meeting DSM-5 criteria for at least moderate depressive symptom severity...
Mek1 is a meiosis-specific kinase in budding yeast which promotes recombination between homologous chromosomes by suppressing double-strand break (DSB) repair sister chromatids. Previous work has shown that the absence of recombinase gene, DMC1, cells arrest prophase due to unrepaired DSBs and activity required this situation prevent breaks using This demonstrates activated response autophosphorylation two conserved threonines, T327 T331, activation loop. Using version can be conditionally...
Decision Support Systems (DSS) can improve farm management decisions and offer the opportunity to productivity limit environmental degradation, both key tenets of sustainable intensification agriculture. While DSS are becoming increasingly useful for agriculture, uptake computer-based support systems by farmers has remained disappointingly low as evidenced studies spanning at least two decades. This paper explores reasons behind this continued lack interest. Is it, previous researchers have...
The Seraph100 Microbind Affinity Blood Filter (Seraph 100) (ExThera Medical, Martinez, CA) is an extracorporeal therapy that can remove pathogens from blood, including severe acute respiratory syndrome coronavirus 2. aim of this study was to evaluate safety and efficacy Seraph 100 treatment for COVID-19.Retrospective cohort study.Nine participating ICUs.COVID-19 patients treated with (n = 53) control matched by site 53).Treatment 100.At baseline, there were no differences between the groups...
Background: Convergent evidence implicates gut microbiota in human health and disease. Hitherto, relatively few studies have evaluated the profile individuals with bipolar disorder (BD) relative to healthy controls (HC). Methods: Fecal samples were collected from subjects (aged 18-65) meeting DSM-5-defined criteria for BD age- sex-matched HC without current or past history of mental major medical disorders. Samples sequenced using Illumina sequencing association specific taxa co-occurrence...
Novel hemoperfusion systems are emerging for the treatment of sepsis. These devices can directly remove pathogens, pathogen-associated molecular patterns, cytokines, and other inflammatory markers from circulation. However, significant safety concerns such as potential antibiotic clearance need to be addressed prior these being used in large clinical studies.