A5003676996- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Consumer Attitudes and Food Labeling
- COVID-19 Pandemic Impacts
- Body Composition Measurement Techniques
- Psychological Well-being and Life Satisfaction
- Muscle metabolism and nutrition
- Nutrition, Genetics, and Disease
- COVID-19 and Mental Health
- Clinical Nutrition and Gastroenterology
- Agriculture Sustainability and Environmental Impact
- Folate and B Vitamins Research
- Frailty in Older Adults
- Metabolomics and Mass Spectrometry Studies
- Muscle Physiology and Disorders
- Liver Disease Diagnosis and Treatment
- Schizophrenia research and treatment
- Primary Care and Health Outcomes
- Cardiac electrophysiology and arrhythmias
- Healthcare Systems and Technology
- Occupational exposure and asthma
- Contact Dermatitis and Allergies
- Drug-Induced Adverse Reactions
Harvard University
2022-2025
Université de Montréal
2024-2025
Montreal Heart Institute
2024-2025
Sinai Hospital
2024
Canadian Apheresis Group
2024
Institut de Valorisation des Données
2024
McGill University Health Centre
2017-2023
McGill University
2017-2023
Centre Hospitalier Universitaire de Grenoble
2004
As the global population ages, it is critical to identify diets that, beyond preventing noncommunicable diseases, optimally promote healthy aging. Here, using longitudinal questionnaire data from Nurses' Health Study (1986–2016) and Professionals Follow-Up (1986–2016), we examined association of long-term adherence eight dietary patterns ultraprocessed food consumption with aging, as assessed according measures cognitive, physical mental health, well living 70 years age free chronic...
Abstract Experimental studies reported biochemical actions underpinning aging processes and mortality, but the relevant metabolic alterations in humans are not well understood. Here we examine associations of 243 plasma metabolites with mortality longevity (attaining age 85 years) 11,634 US (median follow-up 22.6 years, 4288 deaths) 1878 Spanish participants 14.5 525 deaths). We find that, higher levels N2,N2-dimethylguanosine, pseudouridine, N4-acetylcytidine, 4-acetamidobutanoic acid,...
Importance Age-standardized dementia mortality rates are on the rise. Whether long-term consumption of olive oil and diet quality associated with dementia-related death is unknown. Objective To examine association intake subsequent risk assess joint substitution for other fats. Design, Setting, Participants This prospective cohort study examined data from Nurses’ Health Study (NHS; 1990-2018) Professionals Follow-Up (HPFS; 1990-2018). The population included women NHS men HPFS who were free...
A healthy lifestyle is associated with a lower premature mortality risk and longer life expectancy. However, the metabolic pathways of how they relate to longevity are unclear. We aimed identify replicate metabolomic signature examine it related total cause-specific longevity.
Cross-sectional studies have shown that combined low muscle mass and strength are associated with cognitive impairment. Whether mass, reflective of physiologic reserve, is independently faster decline remains unknown.To investigate the associations between in 3 distinct domains among adults aged at least 65 years.The Canadian Longitudinal Study on Aging a prospective population-based cohort study community-dwelling adults. Enrollment occurred from 2011 to 2015 3-year follow-up. Analyses for...
Abstract Background Aging is associated with sarcopenia (low muscle mass) and dynapenia strength) leading to disability mortality. Widely used previous cut‐points for were established from dated, small, or pooled cohorts. We aimed identify of low strength as a determinant impaired physical performance appendicular lean mass (ALM) predictor in single, large, contemporary cohort community‐dwelling older adults compare these criteria others. Methods Cross‐sectional analyses conducted on...
Background: Extending the healthspan – years of lived without disease is a public health priority. Healthy diets have been linked to lower chronic risk, but underlying mechanisms are largely unknown. We previously identified plasma multi-metabolite signatures that measure intakes and metabolic responses different dietary patterns. Hypothesis: Plasma heathy associated with longer healthspan. Methods: studied 12,478 participants from Nurses’ Health Studies Professional Follow-up Study who were...
Introduction: The portfolio diet, a cholesterol-lowering plant-based is recommended for lowering low-density lipoprotein cholesterol (LDL-C), however, less known about its long-term impact on cardiometabolic disease. Objective metabolic response to diet using metabolomics can provide additional insight into how affects disease risk. Objective: To investigate whether metabolomic signature characterize adherence the and this associated with Methods Results: discovery cohort included 633 plasma...
Abstract Background Dairy products provide essential nutrients such as calcium and vitamins B12 D, include bioactive peptides fermented products, which may be beneficial for cognition, especially in older adults. Yet, few studies of large contemporary cohorts have investigated this relationship using sensitive domain-specific cognitive tests. Method In community-dwelling adults the Canadian Longitudinal Study on Aging (2011–2015), we examined cross-sectional associations between total...
Background Thorough dietary assessment is essential to obtain accurate food and nutrient intake data yet challenging because of the limitations current methods. Image-based methods may decrease energy underreporting increase validity self-reported intake. Keenoa an image-assisted diary that integrates artificial intelligence recognition. We hypothesized as valid for automated self-administered 24-hour recall (ASA24)–Canada better appreciated by users. Objective aimed evaluate relative...
Background The COVID-19 pandemic and related lockdowns have impacted lifestyle behaviors, including eating habits physical activity; yet, few studies identified the emerging patterns of such changes associated risk factors. Objective This study aims to identify weight behavior changes, potential factors, resulting from in Canadian adults. Methods Analyses were conducted on 1609 adults (18-89 years old; n=1450, 90.1%, women; n=1316, 81.8%, White) COVIDiet baseline data (May-December 2020)....
Background: Olive oil intake is inversely associated with the risk of chronic diseases and mortality. However, it unclear whether there an association between olive weight changes; because energy-dense food concerns have been raised that high may contribute to gain. Therefore, we aimed determine associations long-term changes in consumption weight. Methods: We examined data from 116,243 women men Nurses’ Health Study (NHS, 1990-2010), NHSII (1991-2015), Professional Follow-up (HPFS,...
Loss of autonomy is often the trigger for institutionalization older adults. A nutritional intervention within a rehabilitation program may attenuate loss muscle mass and function to enable continued in this understudied group seniors. Objectives: 1) To assess feasibility combined nutrient supplementation with regards recruitment, compliance, completion assessments adults losing autonomy; 2) characterize specific population. Seniors taking part were randomized an supplement (EXP: 2 g fish...