A5071663657- Diet and metabolism studies
- Nutritional Studies and Diet
- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Asthma and respiratory diseases
- Immunodeficiency and Autoimmune Disorders
- Birth, Development, and Health
- Sphingolipid Metabolism and Signaling
- Helicobacter pylori-related gastroenterology studies
- Adipose Tissue and Metabolism
- Diet, Metabolism, and Disease
- Gut microbiota and health
- Lipid Membrane Structure and Behavior
- Nutrition and Health in Aging
- Lipid metabolism and disorders
- Eosinophilic Esophagitis
- Pneumocystis jirovecii pneumonia detection and treatment
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Pediatric health and respiratory diseases
- Erythrocyte Function and Pathophysiology
- Sodium Intake and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Nutrition, Genetics, and Disease
Harvard University
2023-2025
Harvard University Press
2025
Shanghai Institute of Nutrition and Health
2020-2022
University of Chinese Academy of Sciences
2020-2022
MedStar Harbor Hospital
2011
Mayo Clinic in Florida
2009-2011
Background Animal studies suggest vital roles of sphingolipids, especially ceramides, in the pathogenesis type 2 diabetes (T2D) via pathways involved insulin resistance, β-cell dysfunction, and inflammation, but human are limited. We aimed to evaluate associations circulating sphingolipids with incident T2D explore underlying mechanisms. Methods findings The current study included 826 men 1,148 women who were aged 50–70 years, from Beijing Shanghai, without 2005 resurveyed 2011....
The health benefits of the Mediterranean diet (MedDiet) have been linked to presence beneficial gut microbes and related metabolites. However, its impact on fecal metabolome remains poorly understood. Our goal was investigate weight loss effects a 1-year lifestyle intervention based an energy-reduced MedDiet coupled with physical activity (intervention group), compared ad libitum (control metabolites, microbiota, their potential association cardiovascular risk factors A total 400...
Background: Extending the healthspan – years of lived without disease is a public health priority. Healthy diets have been linked to lower chronic risk, but underlying mechanisms are largely unknown. We previously identified plasma multi-metabolite signatures that measure intakes and metabolic responses different dietary patterns. Hypothesis: Plasma heathy associated with longer healthspan. Methods: studied 12,478 participants from Nurses’ Health Studies Professional Follow-up Study who were...
Background: Obesity, a major risk factor for cardiovascular disease (CVD), is complex trait with substantial heterogeneity in its etiology, comorbidity risk, and prevention strategies. Hypothesis: Individuals early-onset obesity-related comorbidities ( vs. late-onset) carry different genetic loci obesity varied biological consequences. Methods: We examined longitudinal data from 43,567 participants the Nurses’ Health Studies Professionals Follow-Up Study, including biennial measurements of...
Introduction: Higher coffee consumption has been consistently associated with lower type 2 diabetes (T2D) risk but the underlying mechanisms are largely unknown. Our prior study showed higher intake was improved post-load glucose clarence and insulin sensitivity, visceral adiposity. Hypothesis: We hypothesized that decreased T2D risk, by lowering genetic susceptibility of in pathophysiological pathways related to production, central Methods: analyzed data from 333,053 UK Biobank participants...
Omics data may provide a unique opportunity to discover dairy-related biomarkers and their linked cardiovascular health.Dairy-related lipidomic signatures were discovered in baseline from Chinese cohort study (n=2140) replicated another (n=212). Dairy intake was estimated by validated food-frequency questionnaire. Lipidomics profiled high-coverage liquid chromatography-tandem mass spectrometry. Associations of lipids with 6-year changes risk factors examined the discovery cohort, causalities...
Abstract Inflammation is a critical component of chronic diseases, aging progression, and lifespan. Omics signatures may characterize inflammation status beyond blood biomarkers. We leveraged genetics (Polygenic-Risk-Score; PRS), metabolomics (Metabolomic-Risk-Score; MRS), epigenetics (Epigenetic-Risk-Score; ERS) to build multi-omics-multi-marker risk scores for represented by the level circulating C-reactive protein (CRP), interleukin 6 (IL6), tumor necrosis factor alpha (TNFa). found that...
Although bioactive sphingolipids have been shown to regulate cardiometabolic homeostasis and inflammatory signaling pathways in rodents, population-based longitudinal studies of relationships between onset metabolic syndrome (MetS) are sparse. We aimed determine associations circulating with markers, adipokines, incidence MetS. Among 1242 Chinese people aged 50–70 years who completed the 6-year resurvey, 76 baseline plasma were quantified by high-throughput liquid chromatography-tandem mass...
Background: Plasma metabolites have been associated with type 2 diabetes (T2D) risk and may reflect metabolic homeostasis as a result of the interplay among diet, genetics, gut microbiome. Hypothesis: We hypothesized that specific multi-metabolite signatures can characterize adherence response to various dietary patterns are incident T2D. Methods: analyzed 20578 participants in Nurses’ Health studies Professional Follow-up Study (NHS/HPFS), Hispanic Community Study/Study Latinos, Women’s...