A5062730131- Reproductive System and Pregnancy
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Ovarian function and disorders
- Sperm and Testicular Function
- Assisted Reproductive Technology and Twin Pregnancy
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Estrogen and related hormone effects
- Acute Kidney Injury Research
- Hybrid Renewable Energy Systems
- CAR-T cell therapy research
- Cytokine Signaling Pathways and Interactions
- Structural Analysis and Optimization
- Endometrial and Cervical Cancer Treatments
- Flow Measurement and Analysis
- Evaluation and Optimization Models
- IL-33, ST2, and ILC Pathways
- Gynecological conditions and treatments
- Advanced Sensor and Control Systems
- Ectopic Pregnancy Diagnosis and Management
- Cardiovascular Health and Risk Factors
- Urinary Tract Infections Management
- Cellular and Composite Structures
- Pregnancy and Medication Impact
First Affiliated Hospital of GuangXi Medical University
2019-2025
Guangxi Medical University
2019-2025
Tumor Hospital of Guangxi Medical University
2022
Tianjin University
2014
Nanjing University of Aeronautics and Astronautics
2013
Abstract Background Pancreatic cancer is one of the most lethal types with extremely poor diagnosis and prognosis, chemo-resistance remains a major challenge. The dynamic reversible N 6 -methyladenosine (m A) RNA modification has emerged as new layer epigenetic gene regulation. Methods qRT-PCR IHC were applied to examine ALKBH5 levels in normal pancreatic tissues. Cancer cell proliferation evaluated by clonogenic formation, chemosensitivity detection, Western blotting assays. m A-seq was...
In the endometrium of women with recurrent implantation failure and unexplained miscarriage, expression levels homeobox A10 E-cadherin were positively correlated. To explore whether regulates during endometrial receptivity establishment, Ishikawa RL95-2 cells transfected target-specific small interfering RNA (siRNA) overexpression plasmid A10. The measured by western blot quantitative Real-time Polymerase Chain Reaction (qRT-PCR). Attachment assay JEG-3 spheroids to conducted adhesive...
This study investigates the impact of progesterone resistance on endometrial receptivity and evaluates efficacy pituitary downregulation combined with hormone replacement therapy (HRT) in improving pregnancy outcomes following frozen embryo transfer (FET). A retrospective analysis was conducted 147 patients recurrent implantation failure (RIF) who underwent secretory-phase biopsy subsequent FET treatments at Reproductive Center First Affiliated Hospital Guangxi Medical University between...
<title>Abstract</title> The cytochrome b5 reductase (CYB5R) family of enzymes, consisting five members, has been reported to profoundly affect various physiological and pathological processes. However, it remains unclear how CYB5Rs function have prognostic value in cervical squamous cell carcinoma endocervical adenocarcinoma (CESC). In this study. Gene expression data clinical details 304 CESC patients were acquired from Cancer Genome Atlas (TCGA) database. Data processing visualization...
The adverse effect of ambient PM2.5 exposure on very early pregnancy (VEP) remains controversial among epidemiological studies but is supported by toxicological evidence. We adopted a multicenter retrospective cohort 141,040 cycles to evaluate the VEP using in vitro fertilization and embryo transfer platform high-resolution data China. first investigated association between 1 week before after date VEP. average concentrations 2 weeks were approximately 47 μg/m3. pooled results revealed...
Recurrent miscarriage (RM) is a chronic, heterogeneous autoimmune disease that has serious social and personal consequences. No valid reliable diagnostic markers or therapeutic targets for RM have been identified. Macrophages impact the innate immune system can be used as prognostic many diseases. We first collected 16 decidua villi tissue samples from 5 normal patients 3 single-cell RNA sequencing data analysis identified 1293 macrophage marker genes. then screened recurrent cohort...
Abstract Peripheral blood mononuclear cells (PBMCs) are rich in hematopoietic and mesenchymal stem cells. Platelet-rich plasma (PRP) is various growth factors. PBMCs PRP have been suggested, individually, to restore ovarian function by improving the local microenvironment. The current study investigated effect of granulocyte colony-stimulating factor (G-CSF)-mobilized combined with on restoring rats primary insufficiency (POI). Thirty adult female were randomly subdivided into five groups:...
Endometrial cancer is a type of malignant tumor the female reproductive system. Preserving fertility in endometrial patients currently formidable challenge. Interleukin-24 (IL-24) unique cytokine suppressor gene belonging to IL-10 family. IL-24 has broad-spectrum antitumor activity through different signaling pathways but does not affect normal cells. therapy may provide new method for treatment cancer.Transfection was used transfer. The expression and related pathway proteins tissue...
Objective Peripherally inserted central catheters (PICCs), the most frequent venous catheter, are used to provide medical treatments, although long-term PICC-related adverse outcomes unknown in China. This study systematically investigated complications four Chinese hospitals. Methods Between January 2014 and 2020, we analyzed results of 3550 patients with PICC who were referred All underwent treatment Patient-reported signs symptoms a putative complication or functional studied. Long-term...
Machine learning (ML) models can be used to improve therapeutic schedule and predict outcomes for the women undergoing in vitro fertilization embryo transfer (IVF-ET). However, there is still lacking of a high-quality platform facilitate user-interactive modeling key predictors are under discussion. We aimed build an analytical framework reproductive IVF-ET ascertain crucial clinical factors. Our study adopted various features 53,156 fresh cycles 45,559 from eight typical centers China...
Abstract Background: Hepatocellular carcinoma (HCC) has an extremely poor prognosis due to the development of chemoresistance, coupled with inherently increased stemness properties. Long non-coding RNAs (LncRNAs) are key regulators for tumor cell and chemosensitivity. Currently relevance between LINC00680 progression was still largely unknown, only one study showing its significance in glioblastoma. The herein aimed at identifying role regulation HCC Methods: QRT-PCR used detect expression...
BackgroundWe previously reported that obese mice had significantly high lipid content in embryos, and excessive lipids are detrimental to embryonic development. However, whether maternal obesity has an effect on vitrification injury subsequent pregnancy outcomes is still controversial. This study was conducted clarify the influence of by vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI).MethodsWe retrospectively collected medical record IVF/ICSI patients from reproductive...
To compare the efficacy and safety between laparoscopy local injection with absolute ethanol (AE) for treating tubal ectopic pregnancy (EP). Retrospective cohort study of pregnancies in fallopian tube from two tertiary hospitals January 2015 December 2017. Clinical information such as presenting symptoms, reproductive history, possible risk factors, initial diagnosis, serum beta-human chor-ionic gonadotropin (β-HCG) level, transvaginal ultrasonography findings, methods treatment outcomes...
There exists an exclusive cytokine and tumor suppressor gene, which is called Interleukin 24 (IL-24), in interleukin 10 (IL-10) family with antitumor immune-activating properties. However, pan-cancer analysis of IL-24 for identifying survival prognosis immune infiltration level remains lacking. This study utilized multiple online data approaches, including TIMER, Oncomine, GEPIA the Kaplan-Meier Plotter, analyzing differences expression level, from a perspective. The dissection expounded was...
Objective: Some patients fail to obtain an embryo for transplantation during previous in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles, and require multiple reproductive treatments. This study aimed evaluate whether changing the control ovarian stimulation (COS) protocol subsequent cycle could improve laboratory clinical outcomes these patients. Methods: Patients without a transplantable (TE) IVF/ICSI cycles were recruited their second cycles. They classified...