A5103267416- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Colorectal Cancer Surgical Treatments
- Pancreatic and Hepatic Oncology Research
- Radiation Dose and Imaging
- Colorectal Cancer Screening and Detection
- Appendicitis Diagnosis and Management
- Gastric Cancer Management and Outcomes
- Atomic and Subatomic Physics Research
- Diverticular Disease and Complications
- Gene Regulatory Network Analysis
- Medical Imaging Techniques and Applications
- Coronary Interventions and Diagnostics
- Surgical Simulation and Training
- Pleural and Pulmonary Diseases
- Colorectal Cancer Treatments and Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Aortic Disease and Treatment Approaches
- Cardiac Valve Diseases and Treatments
- Cardiac and Coronary Surgery Techniques
- Rheumatoid Arthritis Research and Therapies
- Pluripotent Stem Cells Research
Krankenhaus der Augustinerinnen
2024
Fraunhofer Institute for Toxicology and Experimental Medicine
2014-2024
St. Claraspital
2021-2023
Düsseldorf University Hospital
2019
Klinik und Poliklinik für Urologie
2019
Heinrich Heine University Düsseldorf
2019
University Hospital Schleswig-Holstein
2008-2018
University of Lübeck
2008-2018
Maastricht University
2011-2018
Raphaelsklinik Münster
2017
Multislice computed tomography (MSCT) has recently evolved as a modality for noninvasive coronary imaging.To assess the accuracy and robustness of MSCT vs criterion standard invasive angiography detection obstructive artery disease.Prospective, single-center study conducted in referral center setting Germany enrolling 103 consecutive patients (mean age, 61.5 [SD, 9.7] years) from November 2003-August 2004 who were undergoing both using scanner with 16 detector rows.Blinded results modalities...
Multidetector computed tomography (MDCT) has been proposed as a noninvasive method to evaluate coronary anatomy.To determine the diagnostic accuracy of 16-row MDCT for detection obstructive disease based exclusively on quantitative analysis and performed in multicenter study.Eleven participating sites prospectively enrolled 238 patients who were clinically referred nonemergency angiography from June 2004 through March 2005. Following low-dose scan artery calcium, 187 with an Agatston score...
PURPOSE: To evaluate the effect of heart rate on quality coronary angiograms obtained with 16–detector row computed tomography (CT) by using temporally enhanced three-dimensional (3D) approaches. MATERIALS AND METHODS: The local ethics committee approved study, and informed consent was from all patients. Fifty patients underwent CT angiography (heart range, 45–103 beats per minute). Raw data helical electrocardiography (ECG) were saved in a combined set. Retrospectively ECG-gated images...
The purpose of this study was to investigate whether spectral computed tomography (CT) has the potential improve luminal depiction by differentiating among intravascular gadolinium-based contrast agent, calcified plaque, and stent material using characteristic k edge gadolinium. A preclinical CT scanner with a photon-counting detector six energy threshold levels used scan phantom vessel. partially occluded simulated plaque isoattenuated surrounding gadolinium chelate solution. reconstructed...
Background The balance between maintenance of the stem cell state and terminal differentiation is influenced by cellular environment. switching these states has long been understood as a transition attractor molecular network. Herein, stochastic fluctuations are either suppressed or can trigger transition, but they do not actually determine states. Methodology/Principal Findings We present novel mathematical concept in which progenitor population dynamics described probabilistic process that...
As diffusion-weighted imaging is increasingly implemented into routine protocols of abdominal MRI, abnormal findings in expected and unexpected locations become more common. The aim our retrospective study was to investigate the specificity restricted diffusion differentiation benign from malignant disease.Two hundred thirty consecutively registered patients underwent MRI including (single-shot spin-echo echo-planar sequence) with b values 0, 150, 500, 1,000 s/mm(2). Lesions were detected by...
Die kardiale Schnittbilddiagnostik mit der Magnetresonanztomografie (MRT) und Computertomografie (CT) hat sich in letzten Dekade technisch rasant weiterentwickelt. Diese Verbesserungen die breite Verfügbarkeit moderner CT- MRT-Systeme haben dazu geführt, dass beide Verfahren jetzt regelmäßig klinischen Routine eingesetzt werden. Dieses deutsche Konsensuspapier wurde daher gemeinsam von Deutschen Gesellschaft für Kardiologie – Herz- Kreislaufforschung, Röntgengesellschaft Pädiatrische...
Abstract Mouse models indicate that metastatic dissemination occurs extremely early; however, the timing in human cancers is unknown. We therefore determined time point of seeding relative to tumour thickness and genomic alterations melanoma. Here, we find lymphatic shortly after dermal invasion primary lesion at a median ~0.5 mm typical driver changes, including BRAF mutation gained or lost regions comprising genes like MET CDKNA2 , are acquired within lymph node colony formation. These...
Background Disseminated cancer cells (DCCs) and circulating tumor (CTCs) are extremely rare, but comprise the precursors of distant metastases or therapy resistant cells. The detailed molecular analysis these may help to identify key events cell dissemination, metastatic colony formation systemic escape. Methodology/Principal Findings Using Ampli1™ whole genome amplification (WGA) technology high-resolution oligonucleotide aCGH microarrays we optimized conditions for structural copy number...
Although thousands of breast cancer cells disseminate and home to bone marrow until primary surgery, usually less than a handful will succeed in establishing manifest metastases months years later. To identify signals that support survival or outgrowth patients, we profile rare marrow-derived disseminated (DCCs) long before manifestation metastasis IL6/PI3K-signaling as candidate pathway for DCC activation. Surprisingly, similar mammary epithelial cells, DCCs lack membranous IL6 receptor...
At the moment of union in fertilization, sperm and oocyte are transcriptionally silent. The ensuing onset embryonic transcription (embryonic genome activation [EGA]) is critical for development, yet its timing profile remain elusive any vertebrate species. We here dissect during EGA by high-resolution single-cell RNA sequencing precisely synchronized mouse one-cell embryos. This reveals a program gene expression (immediate [iEGA]) initiating within 4 h fertilization. Expression iEGA produces...
Almost all studies on diabetic foot syndrome focused prevention of amputation and did not investigate long-term prognosis survival patients as a primary outcome parameter.We retrospective cohort study including 314 who had underwent between December 1995 January 2001.A total 48% received minor (group I), 15% only major II) 36% initially that was followed by III). Statistically significant differences were observed in comparison the median group I to II (51 vs. 40 months; p = 0.016) III (40...
Resection of isolated hepatic or pulmonary metastases from colorectal cancer is widely accepted and associated with a 5-year survival rate 25-40%. The value aggressive surgical management in patients both still remains controversial area.
Esophageal perforation is a life-threatening disease. Factors impacting morbidity and mortality include the cause site of perforation, time to diagnosis, therapeutic procedure. This study aimed identify risk factors for after esophageal perforation.This retrospective analyzed data collected from all patients treated at Department Surgery, University Schleswig-Holstein, Luebeck Campus, January 1986 through December 2011.Altogether, 80 (52 men, 28 women; mean age 65 years) were treated. The...