A5084889431- Cancer Cells and Metastasis
- TGF-β signaling in diseases
- Developmental Biology and Gene Regulation
- Angiogenesis and VEGF in Cancer
- Animal Genetics and Reproduction
- Cancer, Stress, Anesthesia, and Immune Response
- CRISPR and Genetic Engineering
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Xenotransplantation and immune response
- Pluripotent Stem Cells Research
- Chemokine receptors and signaling
- Cancer Immunotherapy and Biomarkers
University Hospital Regensburg
2025
Leibniz Association
2025
Leibniz Institute for Immunotherapy
2025
University of Regensburg
2018-2024
Although thousands of breast cancer cells disseminate and home to bone marrow until primary surgery, usually less than a handful will succeed in establishing manifest metastases months years later. To identify signals that support survival or outgrowth patients, we profile rare marrow-derived disseminated (DCCs) long before manifestation metastasis IL6/PI3K-signaling as candidate pathway for DCC activation. Surprisingly, similar mammary epithelial cells, DCCs lack membranous IL6 receptor...
Members of the Ski/Sno protein family are classified as proto-oncogenes and act negative regulators TGF-ß/BMP-pathways in vertebrates invertebrates. A newly identified member this is fussel (fuss), Drosophila homologue human functional Smad suppressing elements (fussel-15 fussel-18). We others have shown that Fuss interacts with SMAD4 overexpression leads to a strong inhibition Dpp signaling. However, be able characterize endogenous function melanogaster, we generated number state art tools...
Abstract Metastatic dissemination occurs very early in melanoma, often before diagnosis, rendering prevention of metastasis formation an important therapeutic goal. However, the earliest steps lethal patients are incompletely understood. Therefore, this study we searched for detectable disseminated cancer cells (DCC) sentinel lymph node biopsies 492 stage I-III melanoma patients. We used micromanipulator-assisted isolation and single-cell transcriptome analysis these extremely rare DCC...
Abstract The earliest steps of lethal metastasis in patients are incompletely understood. To dissect them, we prospectively searched for the detectable disseminated cancer cells (DCC) sentinel lymph node biopsies 492 stage I-III patients. By visually-controlled, micromanipulator-assisted isolation and single cell transcriptome analysis these extremely rare DCC, identified MCSP + melanoma as strong candidates founder (MFC) nodes. Based on a median follow-up time 6 years, their detection was...
Abstract Members of the Ski/Sno protein family are classified as proto-oncogenes and act negative regulators TGF-ß/BMP-pathways in vertebrates invertebrates. A newly identified member this is fussel ( fuss ), Drosophila homologue human functional Smad suppressing elements fussel-15 fussel-18 ). We others have shown that Fuss interacts with SMAD4 overexpression leads to a strong inhibition Dpp signaling. However, be able characterize endogenous function melanogaster, we generated number state...
Abstract Although thousands of breast cancer cells disseminate and home to bone marrow until primary surgery, usually less than a handful will succeed in establishing manifest metastases months years later. To identify signals that support survival or outgrowth patients, we profiled rare marrow-derived disseminated (DCCs) long before manifestation metastasis identified IL6/PI3K-signaling as candidate pathway for DCC activation. Surprisingly, similar mammary epithelial cells, DCCs lacked...