A5034460571- Corneal Surgery and Treatments
- Hair Growth and Disorders
- Wound Healing and Treatments
- Corneal surgery and disorders
- melanin and skin pigmentation
- Silk-based biomaterials and applications
- Ocular Surface and Contact Lens
- Skin Protection and Aging
- Dermatologic Treatments and Research
- Skin and Cellular Biology Research
- Viral Infectious Diseases and Gene Expression in Insects
- Mesenchymal stem cell research
- Nanoparticles: synthesis and applications
- Tissue Engineering and Regenerative Medicine
- Garlic and Onion Studies
- Immunotherapy and Immune Responses
- T-cell and Retrovirus Studies
- BRCA gene mutations in cancer
- Biochemical Analysis and Sensing Techniques
- Signaling Pathways in Disease
- Extracellular vesicles in disease
- Multiple and Secondary Primary Cancers
- Melanoma and MAPK Pathways
- Hepatitis C virus research
- Rabbits: Nutrition, Reproduction, Health
Academic Center for Education, Culture and Research
2015-2024
Royan Institute
2010-2024
Shahid Beheshti University of Medical Sciences
2014-2024
University of Regensburg
2022-2024
University of Science and Culture
2016-2020
Northwest Hospital
2020
Shahid Beheshti University
2015
The availability of 3D sponges combining proper biochemical, biophysical, and biomechanical properties with enhanced capacity in vivo engraftment vascularization is crucial regenerative medicine. A simple process developed to generate macroporous scaffolds a well‐defined architecture interconnected pores from chicken egg white (EW), material protein‐ growth factor‐binding features which has not yet been employed physicomechanical degradation rates the scaffold are finely tuned by using...
Wound healing remains a burdensome healthcare problem due to moisture loss and bacterial infection. Advanced hydrogel dressings can help resolve these issues by assisting accelerating regenerative processes such as cell migration angiogenesis because of the similarities between their composition structure with natural skin. In this study, we aimed develop keratin-based dressing investigate impact delivery LL-37 antimicrobial peptide using in treating full-thickness rat wounds. Therefore,...
Inflammatory and autoimmune diseases are among the most challenging disorders for health care professionals that require systemic immune suppression which associates with various side effects. Mesenchymal stromal cells (MSCs) capable of regulating responses, mainly through paracrine effects cell-cell contact. Since MSCs advanced therapy medicinal products (ATMPs), they must follow Good Manufacturing Practice (GMP) regulations to ensure their safety efficacy. In this study, we evaluated...
Hypertrophic scar involves excessive amounts of collagen in dermal layer and may be painful. Nowadays, we can't sure about effectiveness procedure for hypertrophic management. The application stem cells with natural scaffold has been the best option treatment burn wounds skin defect, recent decades. Fibrin glue (FG) was among first biomaterials applied to enhance deformity patients. This study aimed identify an efficient, minimally invasive economical transplantation using novel FG from...
Recently, the promising potential of fibroblast transplantation has become a novel modality for skin rejuvenation. We investigated long-term safety and efficacy autologous participants with mild to severe facial contour deformities.In this open-label, single-arm phase IIa clinical trial, total 57 wrinkles (n=37, 132 treatment sites) or acne scars (n=20, 36 who had an evaluator's assessment score at least 2 out 7 (based on standard photo-guide scoring) received 3 injections cultured...
Abstract The earliest steps of lethal metastasis in patients are incompletely understood. To dissect them, we prospectively searched for the detectable disseminated cancer cells (DCC) sentinel lymph node biopsies 492 stage I-III patients. By visually-controlled, micromanipulator-assisted isolation and single cell transcriptome analysis these extremely rare DCC, identified MCSP + melanoma as strong candidates founder (MFC) nodes. Based on a median follow-up time 6 years, their detection was...
This study aimed to identify the optimal growth media for culturing human skin melanocytes clinical applications and assess their tumorigenic potential both in vitro vivo. Various were tested determine most effective safest melanocyte culture, avoiding harmful factors such as TPA colorant toxins. The evaluated changes RAF NRAS gene expression through real-time PCR sequencing of BRAF V600E exons 1 2, comparing these with melanoma. Melanocytes subcutaneously injected into BALB/c nude mice...
Autologous transplantation of epidermal cells has been used increasingly to treat vitiligo patients and is a simple, safe, relatively efficient method. However, the outcome not always satisfactory, some show less or no response this treatment. This study was evaluated identify genes expressed differently among responders non-responders cell find potential markers that could predict 'patients' responses type therapy.Eleven stable who received autologous were included in clinical trial study....
Abstract Objective Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic skin fragility and ultimately lethal blistering disease caused by mutations in the COL7A1 gene which responsible for coding type VII collagen. Investigating pathological mechanisms novel candidate therapies RDEB could be fostered new cellular models. Here, we developed multiple immortalized -deficient keratinocyte cell lines using CRISPR/Cas9 technology as model. Materials Methods In this experimental study,...