A5055112734- Mesenchymal stem cell research
- Corneal Surgery and Treatments
- Wound Healing and Treatments
- Hair Growth and Disorders
- Tissue Engineering and Regenerative Medicine
- Dermatologic Treatments and Research
- Ocular Surface and Contact Lens
- Extracellular vesicles in disease
- Reproductive Biology and Fertility
- Electrospun Nanofibers in Biomedical Applications
- Corneal surgery and disorders
- Protease and Inhibitor Mechanisms
- Metalloenzymes and iron-sulfur proteins
- Ocular Disorders and Treatments
- Facial Rejuvenation and Surgery Techniques
- Lipoproteins and Cardiovascular Health
- Nuclear Structure and Function
- Skin Protection and Aging
- melanin and skin pigmentation
- Skin and Cellular Biology Research
- Metabolism and Genetic Disorders
- Neurological diseases and metabolism
- MicroRNA in disease regulation
- RNA Interference and Gene Delivery
- Connective tissue disorders research
Tehran University of Medical Sciences
2017-2024
Shahid Beheshti University of Medical Sciences
2017-2024
Royan Institute
2010-2020
Academic Center for Education, Culture and Research
2010-2020
Stem Cell Technology Research Center
2018-2020
University of Tehran
2018
Shahid Beheshti University
2010
University of Science and Culture
2010
Latent transforming growth factor (TGF) beta-binding protein 2 (LTBP2) is an extracellular matrix (ECM) that associates with fibrillin-1 containing microfibrils. Various factors prompted considering LTBP2 in the etiology of isolated ectopia lentis and associated conditions such as Weill–Marchesani syndrome (WMS) Marfan (MFS). was screened 30 unrelated Iranian patients. Mutations were found only one WMS proband MFS proband. Homozygous c.3529G>A (p.Val1177Met) shown to cause autosomal...
Purpose: To report the midterm outcomes of autologous limbal stem cell transplantation cultivated on amniotic membrane (AM) with or without subsequent penetrating keratoplasty (PKP) in patients total unilateral deficiency (LSCD). Methods: Eight eyes 8 consecutive LSCD underwent AM. Four optical PKP. Main outcome measures were corneal vascularization and transparency. Results: The followed for 34.0 ± 13.5 months (6-48 months). Seven cases had a stable epithelium marked decrease opacification...
As a biological tissue material, amniotic membrane (AM) has low immunogenicity and to date been widely adopted in clinical practice. However, some features such as biomechanical consistency rapid biodegradation is limited the application of AM. Therefore, this study, we fabricated novel three-dimensional (3D) spongy scaffold made extracellular matrix (ECM) denuded Due their unique characteristics which are similar skin, these scaffolds can be considered an alternative option skin...
To date, the widespread implementation of therapeutic strategies for treatment chronic wounds, including debridement, infection control, and use grafts various dressings, has been time-consuming accompanied by many challenges, with definite success not yet achieved. Extensive studies on mesenchymal stem cells (MSCs) have led to suggestions their in treating diseases. Given existing barriers utilizing such numerous pieces evidence indicating crucial role paracrine signaling system treatments...
Hypertrophic scar involves excessive amounts of collagen in dermal layer and may be painful. Nowadays, we can't sure about effectiveness procedure for hypertrophic management. The application stem cells with natural scaffold has been the best option treatment burn wounds skin defect, recent decades. Fibrin glue (FG) was among first biomaterials applied to enhance deformity patients. This study aimed identify an efficient, minimally invasive economical transplantation using novel FG from...
Wharton's jelly-derived extracellular matrix (WJ-ECM) has attracted researcher's attention for its biomedical applications. Previously, we fabricated a biomimetic spongy scaffold from decellularized WJ-ECM and, in this study, sought to examine the osteogenic inductive potential of and underlying mechanism. To address question, mesenchymal stem cells (MSCs) were isolated WJ using mechanical method cultured on scaffold, under dynamic condition, over 21 days presence or absence medium. The...
Recently, the promising potential of fibroblast transplantation has become a novel modality for skin rejuvenation. We investigated long-term safety and efficacy autologous participants with mild to severe facial contour deformities.In this open-label, single-arm phase IIa clinical trial, total 57 wrinkles (n=37, 132 treatment sites) or acne scars (n=20, 36 who had an evaluator's assessment score at least 2 out 7 (based on standard photo-guide scoring) received 3 injections cultured...