A5032050469- Reconstructive Surgery and Microvascular Techniques
- Salivary Gland Tumors Diagnosis and Treatment
- Facial Trauma and Fracture Management
- Reconstructive Facial Surgery Techniques
- Head and Neck Cancer Studies
- Oral and Maxillofacial Pathology
- Head and Neck Surgical Oncology
- Cancer Diagnosis and Treatment
- Facial Nerve Paralysis Treatment and Research
- Dental Radiography and Imaging
- Cleft Lip and Palate Research
- Ear and Head Tumors
- Temporomandibular Joint Disorders
- Medical and Biological Sciences
- Facial Rejuvenation and Surgery Techniques
- Dental Implant Techniques and Outcomes
- Vascular Malformations and Hemangiomas
- Sinusitis and nasal conditions
- Oral Health Pathology and Treatment
- Dental Trauma and Treatments
- Traumatic Ocular and Foreign Body Injuries
- Body Contouring and Surgery
- Oral and gingival health research
- Parasitic Diseases Research and Treatment
- Oral health in cancer treatment
Grigore T. Popa University of Medicine and Pharmacy
2016-2025
Spitalul Clinic Judeţean de Urgenţe "Sf. Spiridon" Iaşi
2013-2023
King's College London
2022
Guy's and St Thomas' NHS Foundation Trust
2022
King's College Hospital NHS Foundation Trust
2022
Kings Health Partners
2022
Maudsley Charity
2022
National Institute for Health Research
2022
National Health Service
2022
Economic and Social Research Council
2022
Background and Objectives: Oral cancer remains a critical global health concern, with oral squamous cell carcinoma (OSCC) being the most prevalent form. potentially malignant disorders (OPMDs), such as leukoplakia (OLK), lichen planus (OLP), actinic cheilitis (AC), often precede OSCC. Identifying reliable biomarkers is vital for assessing transformation risk. The present study aimed to evaluate immunohistochemical expression of differentiated embryonic chondrocyte 1 (DEC1), marker dysplasia...
Background Limited information is available about the involvement of human papillomavirus (HPV) in head and neck squamous cell carcinomas (HNSCCs) Romanian patients. Objective To evaluate HPV-attributable fraction HNSCCs collected Northeastern Romania. Materials methods In total, 189 formalin-fixed paraffin-embedded tissue samples (99 oral cavity tumors, 28 oropharynx, 48 pharynx, 14 larynx/hypopharynx) were analyzed for HPV DNA RNA using Luminex-based assays, overexpression p16INK4a (p16)...
Adolescents and young adults’ active lifestyles make dental trauma a significant medical concern. Aim: This study aims to assess the etiology, frequency, localization of periodontal in adolescents adults, along with these individuals’ predisposition based on age, gender, residence. Materials Methods retrospective included 109 adults from database Emergency Oral Maxillofacial Surgery department at “Sf. Spiridon” Hospital, Iasi, Romania. The collected data demographic details, mechanisms...
ABSTRACT Although deterioration of silicone maxillofacial prostheses is severely accentuated in smoking patients, the phenomenon has not been systematically studied. To address a gap literature concerning stability during service, this contribution, effect cigarette smoke on aspect and physical properties M511 elastomer was evaluated. The aspect, surface, overall material, pigmented or not, were followed by AFM, color measurements, FTIR, water contact angle TGA‐DTG DSC, hardness compression...
(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV HPVs recognized to be related HNSCCs skin cancers. There no data from Romania regarding involvement herpes polyomaviruses in these types cancer. We aim evaluate association oncogenic Papillomaviridae, Herpesviridae, Polyomaviridae families (2) Methods: A total 26 fresh tumors (6/26 women) were tested for 67 viral agents using a multiplex PCR...
Even if meningiomas are the most common radio-induced tumors that occur in adult population, epidemiology of these types after Chernobyl nuclear accident, is still unclear. This paper aims to determine tumoral behavior intracranial North-Eastern Romania, affected by radioactive cloud from accident , over a period 25 years, namely between 1990 and 2015. Our research consists an analytical, observational, cohort-based retrospective study, conducted Prof. Dr. N. Oblu Clinical Emergency Hospital...
Oral lichen planus (OLP) is a complex chronic inflammatory disorder in which autocytotoxic CD8<sup>+</sup> T cells, locally present the affected tissue, induce basal keratinocyte apoptosis, through release of several cytokines, such as interleukin‑6 (IL‑6). IL‑6 proinflammatory cytokine that related to alterations lipid metabolism psoriasis patients. Impaired together with high serum levels triglycerides have been found association OLP. However, correlation between and dyslipidemia has not...
Dirofilariosis is an infectious disease caused by species of the Dirofilaria genus. It manifested appearance a subcutaneous swelling, especially in eye region. We present case 29-year-old patient that accused facial asymmetry right genian Following clinical and paraclinical evaluations, diagnosis parasitic cyst was established context dirofilariosis with repens (D. repens). Treatment consisted surgical excision formation associated prophylactic antibiotic medication. Macroscopic analysis...
The soft superficial tissues of the face are against gravity through an intricate network ligaments and ligamentous attachments. aim this investigation is to delineate relationship between muscular, fibrous, vascular components musculoaponeurotic system (SMAS) at level its periosteal fixation areas from advanced radiological novel biomarkers’ perspectives. These represent key points underlying skin aging longevity restorative surgery results. Methods: This study was carried out on 37...
The study aimed to present the characteristics of three most prevalent oral potentially malignant disorders, leukoplakia, lichen planus (OLP), and actinic cheilitis, using data from 62 patients collected at “Sfântul Spiridon” Emergency Clinical Hospital in Iași, Romania, between January 2015 2023. results revealed a higher prevalence these lesions among older adults, particularly those over 50 years old, significant gender disparity incidence which was more common males (68%). Leukoplakia...
Midface fractures are common injuries that the result of interpersonal violence, traffic accidents, falls, work-related sports-related or animal aggression. In northeastern part Romania, these a significant health concern that, if left untreated, may lead to functional and esthetic sequelae. Background Objectives: This study aims update statistical data available help promote different lifestyle, with awareness campaigns prevent aggression, domestic violence. Materials Methods: research was...
Routinely measuring epicardial fat had become a novel tool for cardiovascular risk stratification. Structural changes in adipose tissue (EAT), including thickness, inflammation, and angiogenesis, have been described coronary artery disease (CAD) patients. We proposed to measure EAT thickness characterize inflammatory infiltrate angiogenesis CAD patients with without chronic heart failure (CHF), established by cardiac dysfunction on echocardiography (left ventricular ejection fraction, LVEF ≤...
This manuscript highlights key aspects regarding the practical use of botulinum toxin for conservative nonsurgical treatment a rarely encountered, but significant posttraumatic complication-the parotid salivary fistula. It adds information to scarce existing literature on subject. The authors outline main differences between postoperative and trauma-related injury fistula treatment. A total 6 patients with fistulas have been treated by Abobotulinum injections over course 5 years. technique...
The age-associated adiposity and the effect of long-term vitamin D was studied in deficient rats. In vivo experiments, influence a 9 months treatment (weekly oral gavage with 0.125 mg D3 (5000 IU)/100g body weight) on adipocyte precursors from omental adipose tissue examinated. vitro experiment, rat adipose-derived mesenchymal stromal/stem cells (ASCs) were induced to differentiate into adipocytes presence or absence 25(OH)D3 (0.25, 25, 2500 nmol/L). ASCs derived D-treated animals showed an...