A5043698945- Hepatitis B Virus Studies
- Antibiotic Resistance in Bacteria
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Cervical Cancer and HPV Research
- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- Polyomavirus and related diseases
- Antibiotic Use and Resistance
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Parvovirus B19 Infection Studies
- Head and Neck Cancer Studies
- Viral gastroenteritis research and epidemiology
- Infective Endocarditis Diagnosis and Management
- Research on Leishmaniasis Studies
- Reproductive tract infections research
- Diabetes and associated disorders
- Genital Health and Disease
- Tuberculosis Research and Epidemiology
- Urinary Tract Infections Management
- Mycobacterium research and diagnosis
- Hepatitis Viruses Studies and Epidemiology
- Bacterial biofilms and quorum sensing
- COVID-19 Clinical Research Studies
Grigore T. Popa University of Medicine and Pharmacy
2015-2025
Center for Research and Interdisciplinarity
2018
Institutul Cantacuzino
1999
Spitalul Clinic C.F. Iasi
1993
Hadassah Medical Center
1979
The aim of this study was to evaluate the immune and inflammatory responses in COVID-19 patients by dosing specific IgM IgG total antibodies interleukin 6, correlating them with hematological biochemical blood parameters comparing form disease.One hundred twenty-five polymerase chain reaction-confirmed COVID-19, hospitalized between 15.03.2020 1.07.2020 Clinical Hospital Infectious Diseases "Sf. Parascheva" Iaşi, were tested chemiluminescence for presence anti-SARS-CoV-2 IL-6 serum. results...
Background: The rise in multidrug-resistant (MDR) Gram-negative bacteria (GNB) poses a critical threat to global health, exacerbated by the increased use of antibiotics during SARS-CoV-2 pandemic. Colistin, often considered last-resort antibiotic, has seen heightened usage, raising concerns about resistance and clinical outcomes. This study investigates evolution colistin GNB pandemic, with focus on outcomes colistin-treated patients. Methods: Conducted “Saint Spiridon” Hospital, Iasi,...
The incidence of urinary tract infections (UTIs) caused by <em>Klebsiella pneumoniae</em> has exhibited an increasing trend and become a high burden for many public health systems, especially in hospital settings. Multidrug resistance associated with the production extended‑spectrum β‑lactamases (ESBL) among <em>K. isolates is endemic Southeastern Europe. We retrospectively analyzed 75 cases admitted to 'St. Parascheva' Clinical Hospital Infectious Diseases Iasi, Romania, during first 6...
(1) Background: The evolution of bacterial resistance to antibiotics is one the factors that make infectious pathology an extremely dynamic field, also inducing a significant burden on public health systems; therefore, continuous updates and their particular regional patterns crucial for adequate approach various diseases. (2) Methods: We retrospectively analyzed 354 patients with Enterobacterales urinary tract infections (UTIs), determined antibiotic pattern, thus aiming correlate them...
The appearance of the severe acute respiratory syndrome virus-2 (SARS-CoV-2) has had a significant impact on balance public health and social life. data available so far show that newborns young children do not develop forms COVID-19, but small proportion them will still need hospitalization. Even though represent an important vector infection, vaccination at such age was yet considered. Thus, question whether potentially protective antibodies against SARS-CoV-2 could be provided to via...
Background Limited information is available about the involvement of human papillomavirus (HPV) in head and neck squamous cell carcinomas (HNSCCs) Romanian patients. Objective To evaluate HPV-attributable fraction HNSCCs collected Northeastern Romania. Materials methods In total, 189 formalin-fixed paraffin-embedded tissue samples (99 oral cavity tumors, 28 oropharynx, 48 pharynx, 14 larynx/hypopharynx) were analyzed for HPV DNA RNA using Luminex-based assays, overexpression p16INK4a (p16)...
The hepatitis D virus (HDV) superinfection of individuals with chronic B (HBV) infection causes severe liver damage and the poorest long-term prognosis among viral hepatitis. This is attributed to unique pathogenic mechanisms HDV characterized by a direct cytopathic effect on hepatocytes significant impairment host immune response. genotype largely influences extent consequences disease progression towards cirrhosis, decompensation, or hepatocellular carcinoma. In this context, identifying...
Cervical cancer is a major public health problem worldwide. While Romania has the highest incidence of cervical in Europe, prevalence HPV not been evaluated. We report first data on and type distribution Northeast Romania. genotype was investigated 514 consecutively women with or without lesions Genotyping performed Linear Array Genotyping/Roche kit. In our study group, 192/514 (37.4%) patients were positive for (infected single multiple types). Most frequent types were: 16 (10.5%), 53...
The continuous variability of SARS-CoV-2 and the rapid waning specific antibodies threatens efficacy COVID-19 vaccines. We aimed to evaluate antibody kinetics one year after vaccination with an mRNA vaccine in healthcare workers (HCW), or without a booster. A marked decline anti-Spike(S)/Receptor Binding Domain (RBD) levels was registered during first eight months post-vaccination, followed by transitory increase At three post-booster increased level maintained only HCW vaccinated prior...
Background In Romania, a country with no organized national surveillance program regarding cervical cancer, the early diagnosis of HPV (Human Papilloma Virus) infections is major requirement, especially in HIV-infected women. The objective this study was to determine prevalence and type distribution young HIV-positive women assess difference risk factors for developing cancer compared those HIV-negative Method We conducted one cross-sectional cohort from June 2013–September 2014, including...
(1) Background: Head and neck squamous cell carcinomas (HNSCCs) are some of the most frequent malignancies globally. Oncogenic viruses MCPyV, EBV HPVs recognized to be related HNSCCs skin cancers. There no data from Romania regarding involvement herpes polyomaviruses in these types cancer. We aim evaluate association oncogenic Papillomaviridae, Herpesviridae, Polyomaviridae families (2) Methods: A total 26 fresh tumors (6/26 women) were tested for 67 viral agents using a multiplex PCR...
Increased antibiotic resistance of non-fermenting Gram-negative bacilli (NFGNB) associated with increased morbidity and mortality makes the infections they produce a major public health problem. This study aims to assess evolution susceptibility level NFGNB resistance.We carried out retrospective on 994 strains which had been isolated in Clinical Laboratory "Sf. Parascheva" Hospital Infectious Diseases, Iaşi, during period 11 years (2008-2018).Of analyzed, 322 were Acinetobacter spp. 672...
Objective: This study aimed to identify possible differences between blood culture-negative and culture-positive groups of infective endocarditis (IE), explore the associations biological parameters in-hospital mortality. Methods: was a retrospective patients hospitalized for IE 2007 2017. Epidemiological, clinical paraclinical characteristics, by positive groups, were collected. The best predictors mortality based on receiver-operating characteristic (ROC) analysis AUC (area under curve)...
The psoriatic epidermis is more active metabolically and its rate of proliferation faster, showing incomplete differentiation as a result the imbalance between low level cyclic AMP high GMP. levels are due to hyperactivity phosphodiesterase which hydrolyzes AMP. Xanthine derivatives found be potent inhibitors. 15 patients were treated with tablets xanthine (dyphylline, aminophylline). obtained results discussed.
Oral microbiota have shown a higher bacterial diversity in patients with cancers of the digestive tract, levels periopathogens. Recent studies that Fusobacterium links to gastro-intestinal neoplastic tissue and accelerates its progression, as well worsening patient outcome. The present pilot study was carried out between February December 2020 evaluate possible association abundance some periopathogens (Fusobacterium nucleatum, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans,...
Introduction: The COVID-19 disease and anti-SARS-CoV-2 vaccination were accompanied by alterations in several inflammatory markers. aim of our research was to check what extent such cytokines are transferred infants via the breastmilk SARS-CoV-2-infected or vaccinated mothers. Thus, we wanted if breastfeeding is safe during SARS-CoV-2 infection after mRNA-vaccination. Material method: Luminex Multiplexing Assay used for quantifying 10 cytokine human COVID-19-vaccinated mothers, compared with...