The gut microbiota is emerging as an important contributor to the homeostasis of human body through its involvement in nutrition and metabolism, protection against pathogens, development modulation immune system. It has therefore become research topic recent decades. Although association between intestinal dysbiosis numerous digestive pathologies been thoroughly researched, pancreatic diseases constitutes a novelty specialized literature. In years, growing evidence pointed critical pancreas...

Congenital hyperinsulinism (CHI) is a rare disorder of glucose metabolism and the most common cause severe persistent hypoglycemia (hyperinsulinemic hypoglycemia, HH) in neonatal period childhood. Most cases are caused by mutations ABCC8 KCNJ11 genes that encode ATP-sensitive potassium channel (KATP). We present correlation between genetic heterogeneity variable phenotype patients with early-onset HH gene mutations. In first patient, who presented since day life, molecular testing revealed...

Maturity-onset diabetes of the young (MODY) is part heterogeneous group monogenic (MD) characterized by non-immune dysfunction pancreatic β-cells. The diagnosis MODY still remains a challenge for clinicians, with many cases being misdiagnosed as type 1 or 2 mellitus (T1DM/T2DM), and over 80% remaining undiagnosed. With introduction modern technologies, important progress has been made in deciphering molecular mechanisms etiology MD, including MODY. aim our study was to identify genetic...

Hereditary thoracic aorta diseases (HTADs) are a heterogeneous group of rare disorders whose major manifestation is represented by aneurysm and/or dissection frequently located at the level ascending aorta. The have an insidious evolution and can be encountered as isolated or also associated with systemic, extra-aortic manifestations (syndromic HTADs). Along development molecular testing technologies, important progress has been made in deciphering etiology HTADs. aim this study to identify...

Vitamin D plays an important role in maintaining bone health with numerous benefits for extraskeletal as well.

Routinely measuring epicardial fat had become a novel tool for cardiovascular risk stratification. Structural changes in adipose tissue (EAT), including thickness, inflammation, and angiogenesis, have been described coronary artery disease (CAD) patients. We proposed to measure EAT thickness characterize inflammatory infiltrate angiogenesis CAD patients with without chronic heart failure (CHF), established by cardiac dysfunction on echocardiography (left ventricular ejection fraction, LVEF ≤...

Gastroesophageal reflux disease (GERD) is a common digestive condition, representing one of the most frequent reasons for medical examination, especially in pediatric gastroenterology departments. GERD could be associated with biochemical alterations either its systemic manifestations or markers complications. The aim our paper was to evaluate parameters secondary children. Two hundred and sixty-seven children both genders aged between 1 month 18 years who displayed suggestive symptoms this...

Abstract: Congenital hyperinsulinism (CHI) is a rare disorder of glucose metabolism and the most common cause severe persistent hypoglycemia (hyperinsulinemic hypoglycemia, HH) in neonatal period childhood. Most cases are caused by mutations ABCC8 KCNJ11 genes that encode ATP-sensitive potassium channel (KATP). We present correlation between genetic heterogeneity variable phenotype patients with early-onset hyperinsulinemic gene mutations. In first patients, which presented since day life,...

Viral infections have always been considered a threat to global health, with numerous outbreaks across time. Despite the relative recent experience coronavirus-associated diseases such as severe acute respiratory syndrome (SARS) and Middle East (MERS), syndrome-2’s (SARS-CoV-2) continuous evolution displays different behavior. With tropism for both digestive mucosa, coronavirus disease 2019 (COVID-19) inflammatory bowel (IBD) seem share particular common background. Current literature offers...

Celiac disease (CeD) is an enteropathy caused by the complex interaction between genetic, environmental, and individual immunological factors. Besides hallmark of intestinal mucosal damage, CeD a systemic disorder extending beyond gastrointestinal tract impacting various other organs, causing extraintestinal atypical symptoms. The association liver damage has been classified into three main categories: mild asymptomatic injury, autoimmune failure. We present case severe with cirrhotic...

The aim of the study is to analyse and discuss main mucosal, dental cutaneous manifestations in oral area associated with anorexia adolescent patients, order raise awareness among healthcare providers caregivers about specific health challenges faced by this population highlight need for early intervention tailored care strategies. Methods: We performed a systematic search on PubMed Embase databases from their inception March 2024 using key-words: [“anorexia”] AND [“adolescent” OR...

The prevalence of obesity among children is rising and over the years we can estimate severity medical issues at adult age. According to latest studies also personal experience are already seeing first signs diabetes, high blood pressure non-alcoholic fatty liver disease (NAFLD) in adolescents. excess sugar refined carbohydrates associated with a sedentary lifestyle has multiple negative effects for organism risk comorbidities, especially dental health children. We notice problems field here...

Background and Objectives: Colitis with Clostridium difficile is an important health problem that occurs intensity varies between mild severe. Surgical interventions are required only in fulminant forms. There little evidence regarding the best surgical intervention these cases. Materials Methods: Patients C. infection were identified from two surgery clinics 'Saint Spiridon' Emergency Hospital Iași, Romania. Data presentation, indication for surgery, antibiotic therapy, type of toxins,...

Obstructive sleep apnea syndrome is a multisystemic disorder associated with series of side effects. (OSAS) includes hypoxemia and correlated an increased incidence for various neuronal conditions, including glaucoma, strokes, reduced mental ability, depressive disorders, peripheral neuropathy, non-arteritic ischemic optic neuropathy. This study’s aims are the evaluation degree ocular surface damage in obstructive patients (in absence continuous positive airway pressure treatment) structural...

(1) Background: An open abdomen is a serious medical condition that requires prompt and effective treatment to prevent complications improve patient outcomes. Negative pressure therapy (NPT) has emerged as viable therapeutic option for temporary closure of the abdomen, offering several benefits over traditional methods. (2) Methods: We included 15 patients with pancreatitis who were hospitalized in I-II Surgery Clinic Emergency County Hospital "St. Spiridon" from Iasi, Romania, between...

Congenital choledochal cysts are more frequently diagnosed in children under the age of 10, occurring prevailingly female patients. We presenting a case cyst 7-month-old male baby, which had sudden onset with scleral-cutaneous jaundice and lack appetite. Abdominal ultrasound revealed transonic, hyperreflective formation located topography main bile duct, dilated intrahepatic ducts, laboratory tests severe syndrome hepatic cytolysis cholestasis. The diagnosis was confirmed using...

Endoscopia digestivă intervenţională în populaţia pediatrică este o etapă esenţială algoritmul diagnostic şi terapeutic la copiii cu diferite patologii din sfera gastrointestinală, marcată evoluţie practica medicală curentă.Articolul de faţă descrie situaţiile care tehnica necesară mod electiv sau urgenţă, descrierea metodei, a indicaţiilor, dar complicaţiilor pot surveni.Procedura se practică către gastroenterologul endoscopistul pediatru, asistat uneori pentru adulţi, sub anestezie...

Chist congenital de coledoc la un sugarcaz clinic şi review literatură REZUMATChistul este mai frecvent diagnosticat copiii până 10 ani, afectând preponderent persoanele sex feminin.Prezentăm caz chist coledocian sugar masculin în vârstă 7 luni, care a debutat brusc cu icter sclerotegumentar inapetenţă.Ecografia abdominală evidenţiat o formaţiune transsonică, hiperreflectogenă, localizare pe topografia coledocului, căi biliare intrahepatice dilatate, iar examenele laborator au decelat...

Interventional digestive endoscopy in the pediatric population is major procedure diagnostic and therapeutic algorithm children with different pathologies gastrointestinal spectrum a marked evolution current medical practice.This article attempts to describe all situations where this technique required electively or as matter of urgency, providing description method, indications, well complications that may arise.The interventional performed by gastroenterologist technician, sometimes...

Papillary thyroid microcarcinoma (PTMC) is a common malignant disease of the endocrine system, which has rapidly increased in incidence and prevalence recent decades. The aim our paper was to identify correlations between pathological clinical features cases PTMC. A total 612 patients both genders, who were operated on for benign diseases 3rd Surgical Unit St. Spiridon University Hospital Iasi, monitored period 2 years. According reports, PTMC diagnosed 144 cases. Of those cases, 81.2%...