A5024025029- Innovative Energy Harvesting Technologies
- Advanced MEMS and NEMS Technologies
- Advanced Sensor and Energy Harvesting Materials
- Genomic variations and chromosomal abnormalities
- Energy Harvesting in Wireless Networks
- 3D IC and TSV technologies
- Genetics and Neurodevelopmental Disorders
- Genomics and Rare Diseases
- Genetic Syndromes and Imprinting
- Congenital heart defects research
- Mechanical and Optical Resonators
- Characterization and Applications of Magnetic Nanoparticles
- Wireless Power Transfer Systems
- Microfluidic and Bio-sensing Technologies
- Ferroelectric and Piezoelectric Materials
- Thin-Film Transistor Technologies
- Prenatal Screening and Diagnostics
- Semiconductor materials and devices
- Protein Tyrosine Phosphatases
- Modular Robots and Swarm Intelligence
- Chromosomal and Genetic Variations
- Tracheal and airway disorders
- Force Microscopy Techniques and Applications
- Genetic factors in colorectal cancer
- Glycogen Storage Diseases and Myoclonus
RISE Research Institutes of Sweden
2018-2024
Grigore T. Popa University of Medicine and Pharmacy
2013-2024
Clinical Emergency Hospital Bucharest
2020
Gheorghe Asachi Technical University of Iași
2019-2020
Spitalul Clinic de Urgență pentru Copii Cluj-Napoca
2020
Institutul Regional de Oncologie
2020
Biopathologie de la myéline, neuroprotection et stratégies thérapeutiques
2018
Fiber Optic Valley
2018
Institutul Regional de Gastroenterologie Prof. Dr. Octavian Fodor
2018
Victor Babeș University of Medicine and Pharmacy Timișoara
2010
Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets opposing interactions, one with heterotetrameric complexes cell surface receptors, the other secreted antagonists that act as ligand traps. We identified mutations (N445K,T) in patients multiple synostosis syndrome (SYM1) BMP-related GDF5. Functional studies both mutants chicken micromass culture demonstrated a gain function caused resistance to BMP-inhibitor NOGGIN and an altered signaling effect. Residue N445,...
Using magnetic particles with sizes in the nanometer range biomedical separation has gained much interest recently due to their higher surface area particle volume and lower sedimentation rates. In this paper, we report our both theoretical experimental investigation of motion a field gradient from 425 nm down 50 nm. measurements, monitor absorbance change sample as concentration varies over time. We also implement Brownian dynamics algorithm investigate influence interactions during compare...
Different microelectromechanical system (MEMS) packaging strategies towards high density of MEMS devices and lower expenditure exist both in the market research. For example, electrical interconnections low stress wafer level are essential for improving device performance. Hybrid integration temperature co-fired ceramics (LTCC) with Si can be a way an easier integrated interconnection, as well costs. Our research on LTCC-Si is reported this paper.
Estimates of rare disease (RD) population impact in terms number affected patients and accurate definition is hampered by their under-representation current coding systems. This study tested the use a specific RD codification system (ORPHAcodes) five European countries/regions (Czech Republic, Malta, Romania, Spain, Veneto region-Italy) across different data sources over period January 2019-September 2021.Overall, 3133 ORPHAcodes were used to describe diagnoses, mainly corresponding...
Serotoninergic activation which decreases brain Aβ peptides is considered beneficial in mouse models for Alzheimer's disease (AD), but the mechanisms involved remain unclear. Because growing evidence suggested that stimulation of proteases digesting Aβ, especially endopeptidase neprilysin (NEP) may be effective AD therapy/prevention, we explored involvement serotonin precursors and derivatives NEP regulation. We found 5-hydroxyindolacetic acid (5-HIAA), final metabolite serotonin, until now...
We have developed a micromachined flow cell consisting of channel integrated with micropipettes. The is used in combination an optical trap setup (optical tweezers) to study mechanical and structural properties /spl lambda/-DNA molecules. was realized using silicon micromachining including the so-called buried technology fabricate micropipettes, wet etching glass create channel, powder blasting make fluid connections. volume 2 mu/l. pipettes length 130 mu/m, width 5-10 round opening 1 mu/m...
Farming is facing many economic challenges in terms of productivity and cost-effectiveness. Labor shortage partly due to depopulation rural areas, especially Europe, another challenge. Domain specific problems such as accurate monitoring soil crop properties animal health are key factors for minimizing economical risks, not risking human health. The ECSEL AFarCloud (Aggregate the Cloud) project will provide a distributed platform autonomous farming that allow integration cooperation...
Here, we present a MEMS atomic force microscope sensor for use inside transmission electron (TEM). This enables direct in situ TEM measurements the nanonewton range and thus mechanical characterization of nanosized structures. The main design challenges system are to reach high sensitivity make compact that allows be fitted narrow dimensions pole gap TEM. In order miniaturize sensing device, an integrated detection with piezoresistive elements arranged full Wheatstone bridge was used....
Wolf–Hirschhorn syndrome (WHS), a rare disorder determined by distal 4p deletion, is characterized pre and postnatal growth retardation, hypotonia, intellectual disability, epilepsy, craniofacial dysmorphism, congenital fusion anomalies. The clinical aspects are dependent on the deletion’ size. Our aim was to identify specific characteristics in cohort of seven cases with deletion assess utility Multiplex ligation-dependent probe amplification (MLPA) (cheap sensitive test)—combined kits—as...
Mutations in RAS, BRAF, PIK3CA, and TP53 are well-established genetic abnormalities metastatic colorectal cancer (mCRC). However, limited information is available for patients from Eastern Europe, including Romania. In this retrospective analysis, we investigated 104 mCRC the Northeastern region of Romania to determine frequency, distribution, coexistence, clinicopathological molecular correlations these mutations. was most frequently mutated gene (73.1%), followed by KRAS (45.2%) PIK3CA...
Thick poly-SiGe layers, deposited by plasma-enhanced chemical vapor deposition (PECVD), are very promising structural layers for use in microaccelerometers, microgyroscopes or thin-film encapsulation, especially applications where the thermal budget is limited. In this work it shown first time that these an attractive alternative to low-pressure CVD (LPCVD) poly-Si because of their high growth rate (100-200 nm/min) and low temperature (520°C-590°C). The combination both features impossible...
In this paper a new concept of integrating micromachined high-resistivity (HR) silicon dielectric resonator antennas (DRAs) compatible with millimeter wave multichip module deposited (MCM-D) process based on multiple layers benzocyclobuthene (BCB) is presented. The HR Si wafer used not only as carrier substrate for the BCB but also manufacturing integrated antenna elements. A 4times8 focal plane array (FPA) was designed use in 94 GHz imaging radar system. Each channel uses small 2times2 DRA...
Magnetoelectric (magnetic/piezoelectric) heterostructures bring new functionalities to develop novel transducer devices such as (wireless) sensors or energy harvesters and thus have been attracting research interest in the last years. We studied magnetoelectric coupling between Metglas films (2826 MB) poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) a laminate structure. The metallic film itself served bottom electrode top we used an electrically conductive polymer,...
This paper describes two novel processes for depositing poly-SiGe films at CMOS-compatible temperatures (/spl les/450/spl deg/C). A range of deposition is investigated to ensure compatibility with different CMOS generations. While the multilayer process investigates ranging between 420-450/spl deg/C, microcrystalline SiGe has been made possible as low 300/spl deg/C. These are optimized obtain stress and gradient values suitable MEMS structural layers. Low SiGe-Al contact resistivity on order...
ABSTRACT Ring chromosomes are rare entities, usually associated with phenotypic abnormalities in correlation the loss of genetic material. There various breakpoints and sometimes there is a dynamic mosaicism that reflected clinical features. Most ring de novo occurrences. Our study reflects experience three Romanian cytogenetic laboratories field chromosomes. We present six cases involving 5, 13, 18, 21. All were identified after birth children plurimalformative syndromes. The chromosome was...