A5083519161- Crystallization and Solubility Studies
- Carbohydrate Chemistry and Synthesis
- Conducting polymers and applications
- Advanced biosensing and bioanalysis techniques
- Advanced Polymer Synthesis and Characterization
- Lanthanide and Transition Metal Complexes
- Polymer Surface Interaction Studies
- Advanced Photocatalysis Techniques
- Phenothiazines and Benzothiazines Synthesis and Activities
- Botanical Studies and Applications
- Glycosylation and Glycoproteins Research
- Biopolymer Synthesis and Applications
- X-ray Diffraction in Crystallography
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Cannabis and Cannabinoid Research
- Natural product bioactivities and synthesis
- Organic Light-Emitting Diodes Research
- Magnetism in coordination complexes
- Phytochemistry and Bioactivity Studies
- Iron oxide chemistry and applications
- Synthesis and Reactivity of Heterocycles
- Phytochemical compounds biological activities
- Nanoparticle-Based Drug Delivery
- Coffee research and impacts
Romanian Academy
2011-2024
Institute of Macromolecular Chemistry
2013-2024
Institutul de Chimie Macromoleculară Petru Poni
2010-2021
Gheorghe Asachi Technical University of Iași
2013-2015
New dihydro-pyrrol-2-one compounds, featuring dual sulfonamide groups, were synthesized through a one-pot, three-component approach utilizing trifluoroacetic acid as catalyst. Computational analysis using density functional theory (DFT) and condensed Fukui function explored the structure–reactivity relationship. Evaluation against human carbonic anhydrase isoforms (hCA I, II, IX, XII) revealed potent inhibition. The widely expressed cytosolic hCA I was inhibited across range of...
This study aimed to obtain and characterize extracted hemp oil enriched in cannabidiol (CBD) by decarboxylation of cannabidiolic acid (CBDA) give new insights into its antioxidant anticancer effects. Optimization CBDA was performed, CBD contents purities were determined flash chromatography, 1H- 13C-NMR. The properties CBD-enriched investigated Fe2+ chelating activity, Fe3+ reducing power assay, O2●− scavenging HO● ability lipid peroxidation inhibitory cytotoxicity, apoptosis- oxidative...
The therapeutic efficiency of plant extracts has been limited by their poor pharmaceutical availability. Hydrogels have promising potential to be applied as wound dressings due high capacity absorb exudates and enhanced performance in loading releasing extracts. In this work, pullulan/poly (vinyl alcohol) (P/PVA) hydrogels were first prepared using an eco-friendly method based on both a covalent physical cross-linking approach. Then, the loaded with hydroalcoholic extract Calendula...
Ailanthus altissima, an invasive plant species, exhibits pharmacological properties, but also some allergic effects on humans. This study aimed to evaluate the potential toxicity of A. altissima leaves, using a complex approach towards different organisms. The ecotoxic impact crude extract was investigated seeds germination and brine shrimp lethality. Cytotoxicity studied in vitro non-target (haemolysis, liposomal model, fibroblast), target (cancer cells) assays. Leaf at 1000 µg/mL...
Novel 3-sulfonamide pyrrol-2-one derivatives containing two sulfonamide groups were synthesized via a one-pot, three-component method using trifluoroacetic acid as catalyst. Structural confirmation was achieved spectroscopic techniques. The compounds tested against four selected human carbonic anhydrase isoforms (hCA I, hCA II, IX, and XII). Most showed significant selectivity for with 4h, 4i, 4n, 4k, 4j demonstrating enhanced activity due to methoxy hydroxy group patterns. Compound 4o...
Abstract The objective of the paper was to investigate chemical composition Inula helenium roots extracts and evaluate antioxidant potential conferred by constituents. GC/MS HPLC/MS techniques were used characterize two separated from extraction with chloroform ethyl acetate, respectively. Volatile compounds have been identified GC their mass spectra retention time values, while HPLC identification phenolic realized comparing times, UV MS those standards or literature data. Measurements...
, a highly invasive species, contains valuable compounds in different plant parts, indicating great practical potential. This paper proposes the use of non-polar (
A novel inclusion complex of the propiconazole nitrate (NO3PCZ) with β-cyclodextrin (β-CD) was prepared by treatment (PCZ) an acidic nitrating agent. The formation NO3PCZ and its β-CD has been studied NMR, ESI-MS, TGA, DSC methods. Using undecoupled signal in HMBC correlation spectra, almost identical coupling constants CH from trizolic ring PCZ compounds ((1)J(HC)3=207 Hz, (1)J(CH)5=214 for PCZ; (1)J(HC)3=208 Hz (1)J(CH)5=215 NO3PCZ) were determined, confirming that geometry heterocyclic...
Multivalent biorecognition of lectin layers by glyconanoparticle sugar-clusters has been used to generate multilayer nanoplatform architectures in a QCM sensing setup.
AbstractThe aim of this study was to investigate the phenolic content and antibacterial activity methanol extract from Helichrysum arenarium (L.) Moench subsp. inflorescences against lower respiratory tract pathogens (standard strains clinical isolates). The characterised by a total 160.17 mg/g. Several caffeic acid conjugates (chlorogenic dicaffeoylquinic acids) flavonoids (apigenin, naringenin, apigenin-7-O-glucoside naringenin-O-hexosides) were identified as major constituents...
The paper aims to investigate the cytotoxic effect on tumor cells of irradiated AuNPs in green light and subsequently functionalized with HS-PEG-NH
6-Iodo-substituted carboxy-quinolines were obtained using a one-pot, three-component method with trifluoroacetic acid as catalyst under acidic conditions. Iodo-aniline, pyruvic and 22 phenyl-substituted aldehydes (we varied the type number of radicals) or O-heterocycles, resulting in different electronic effects, starting components. This approach offers advantages such rapid response times, cost-effective catalysts, high product yields efficient purification procedures. A comprehensive...
ABSTRACT Although deterioration of silicone maxillofacial prostheses is severely accentuated in smoking patients, the phenomenon has not been systematically studied. To address a gap literature concerning stability during service, this contribution, effect cigarette smoke on aspect and physical properties M511 elastomer was evaluated. The aspect, surface, overall material, pigmented or not, were followed by AFM, color measurements, FTIR, water contact angle TGA‐DTG DSC, hardness compression...