A5066254565- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Analytical Methods in Pharmaceuticals
- Polysaccharides Composition and Applications
- Wound Healing and Treatments
- Computational Drug Discovery Methods
- Analytical Chemistry and Chromatography
- Microbial Metabolic Engineering and Bioproduction
- Probiotics and Fermented Foods
- Cannabis and Cannabinoid Research
- Circular RNAs in diseases
- Phytochemicals and Antioxidant Activities
- Insect Pest Control Strategies
- Hibiscus Plant Research Studies
- Coffee research and impacts
- Phytochemical compounds biological activities
- Microbial Metabolites in Food Biotechnology
- Supramolecular Chemistry and Complexes
- Silymarin and Mushroom Poisoning
- Synthesis and bioactivity of alkaloids
- Biochemical and biochemical processes
- Phytochemicals and Medicinal Plants
- Characterization and Applications of Magnetic Nanoparticles
- Caveolin-1 and cellular processes
- Nanocomposite Films for Food Packaging
Romanian Academy
2014
This study aimed to obtain and characterize extracted hemp oil enriched in cannabidiol (CBD) by decarboxylation of cannabidiolic acid (CBDA) give new insights into its antioxidant anticancer effects. Optimization CBDA was performed, CBD contents purities were determined flash chromatography, 1H- 13C-NMR. The properties CBD-enriched investigated Fe2+ chelating activity, Fe3+ reducing power assay, O2●− scavenging HO● ability lipid peroxidation inhibitory cytotoxicity, apoptosis- oxidative...
Ailanthus altissima, an invasive plant species, exhibits pharmacological properties, but also some allergic effects on humans. This study aimed to evaluate the potential toxicity of A. altissima leaves, using a complex approach towards different organisms. The ecotoxic impact crude extract was investigated seeds germination and brine shrimp lethality. Cytotoxicity studied in vitro non-target (haemolysis, liposomal model, fibroblast), target (cancer cells) assays. Leaf at 1000 µg/mL...
Biopolymeric drug delivery systems enhance the bioavailability and therapeutic efficacy of poorly soluble bioactive compounds. In this study, chitosan (Chi), dextran (Dex), carboxymethyl (mDex), lignin (L), curcumin (Cu) were combined to develop materials with controlled release, antioxidant, anti-inflammatory properties. The mechanical evaluation showed that Chi-mDex-L-Cu exhibited highest diametral tensile strength (2.40 MPa), a 1233% increase compared Chi-mDex-L, due strong hydrogen...
This study presents the development of new formulations consisting dextran (Dex) and chitosan (Ch) matrices, with fillings such as stearate (MCh), citric acid, salicylic or ginger extract. These materials were characterized using Fourier-Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), mechanical tests, evaluated for antioxidant properties, including scavenging activities, metal chelation, ferric ion reducing power, well anti-inflammatory measuring binding affinity...
In this study a natural culture medium that mimics the synthetic yeast peptone glucose used for fermentations was designed to screen and select yeasts capable of producing high levels diacetyl acetaldehyde. The presence whey powder sodium citrate in along with manganese magnesium sulfate enhanced both biomass aroma development. A total 52 strains were cultivated two different media, namely, acetaldehyde-diacetyl medium. initial screening based on qualitative reaction acetaldehyde Schiff's...
Vascular inflammation plays a crucial role in the progression of various pathologies, including atherosclerosis (AS), and thus it has become an attractive therapeutic target. The protocatechuic acid (PCA), one main metabolites complex polyphenols, is endowed with anti-inflammatory activity, but its formulation into nanocarriers may increase bioavailability. In this study, we developed characterized dextran shell‒iron oxide core nanoparticles loaded PCA (MNP-Dex/PCA) assessed their...
Lactic acid bacteria (LAB) produce important metabolites during fermentation processes, such as exopolysaccharides (EPS), which represent powerful natural antioxidants. On the other hand, H. sabdariffa L. anthocyanin extracts protect LAB and support their development. This study uncovers for first time, antioxidant profile of Weissella confusa PP29 probiotic media focuses on elevating its impressive attributes by synergistically integrating extract. The multifaceted potential this innovative...
, a highly invasive species, contains valuable compounds in different plant parts, indicating great practical potential. This paper proposes the use of non-polar (
Glioblastoma (GB) is the most aggressive and recurrent form of brain cancer in adults. We hypothesized that identification biomarkers such as certain microRNAs (miRNAs) circulating microvesicles (MVs) transport them could be key to establishing GB progression, recurrence therapeutic response. For this purpose, MVs were isolated from plasma patients (before after surgery) healthy subjects characterized by flow cytometry. OpenArray profiling individual quantification selected miRNAs was...
Current trends in the development of wound dressings are oriented towards use biopolymer-based materials, due to their unique properties such as non-toxicity, hydrophilicity, biocompatibility and biodegradability, that have advantageous therapeutic characteristics. In this regard, present study aims develop hydrogels based on cellulose dextran (CD) reveal anti-inflammatory performance. This purpose is achieved by incorporating plant bioactive polyphenols (PFs) CD hydrogels. The assessments...
This study aimed to obtain and characterize extracted hemp oil enriched in cannabidiol (CBD) by decarboxylation of cannabidiolic acid (CBDA) give new insights into its antioxidant anticancer effects. Optimization CBDA was performed, CBD contents purities were determined “flash chromatography”, 1H- 13C-NMR. The properties CBD-enriched investigated Fe2+ chelating activity, Fe3+ reducing power assay, O2− scavenging HO− ability lipid peroxidation...
The toxicity of viologens can be significantly reduced by including them in tight [2]rotaxane structures alongside β-cyclodextrin, thus turning into candidates pharmaceutical interest. Here, we report a synthesis pathway for benign viologen, capping small β-cyclodextrin-caged molecule, the 4,4'-bipyridine, with minimal-length presynthesized axle-stopper segments propyl-3-pentamethyldisiloxane type. After 90 min from oral administration to laboratory mice, product concentration bloodstream...
In this study, we proposed formulations of diminazene aceturate (DA) designed to improve its bioavailability and maximize the therapeutic index in animals by overcoming rapid degradation under acidic pH stomach. An important consequence is fact that amount bloodstream close administered dose. This was made possible incorporating DA into β-cyclodextrin's (βCD) cavity a molar ratio 1:1. The structure resulted inclusion complex established Raman, DSC, Wide-Angle X ray Diffraction (WAXD) solid...
To date, there are very few data regarding new efficient probiotics’ development with their own prebiotic substrate. All commercial products contain substrate that was previously purified from external sources and added to the final product. The present study describes Weissella confusa strain fermentations in media different anthocyanin concentrations Hibiscus sabdariffa L., order increase exopolysaccharide (EPS) yield, leading augmented probiotic properties. extracted EPS were...
Zoledronic acid (ZA) is used in the treatment of various bone pathologies, but it forms complexes with calcium ions present body fluids, decreasing ZA bioavailability. Thereby, study first describes identification ZA-calcium that form calcium-rich environments, order to establish bioavailable concentration. Then, a new method for quantification low amounts milieus mimics vivo conditions by using simulated fluid and sulfate hemihydrate was described. Almost all analytical methods described...
Generally, NSAIDs are weakly soluble in water and contain both hydrophilic hydrophobic groups. One of the most widely used is ibuprofen, which has a poor solubility high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can increase dissolution rate low aqueous drugs, operating as drug delivery vehicle, additionally contributing significantly to chemical stability pharmaceuticals reducing drug-related irritability. In order...
The study aim was to develop and validate a high-performance liquid chromatography-electrospray ionization mass spectrometry (HPLC-ESI-MS) method simultaneously determine glibenclamide (Gli) silymarin (Sil) released from chitosan (CS) microparticles in aqueous solutions. CS were synthesized using an ionic gelation method, their morphology, swelling degree, encapsulation efficiency active substance release investigated. Gli Sil loaded different concentrations, identification quantification...