A5088595696- Synthesis and biological activity
- Synthesis and Characterization of Heterocyclic Compounds
- Free Radicals and Antioxidants
- Synthesis and Reactions of Organic Compounds
- Computational Drug Discovery Methods
- Inflammatory mediators and NSAID effects
- Synthesis of heterocyclic compounds
- Advanced Drug Delivery Systems
- Phytochemicals and Antioxidant Activities
- Analytical Methods in Pharmaceuticals
- Eicosanoids and Hypertension Pharmacology
- Natural Antidiabetic Agents Studies
- Nanocomposite Films for Food Packaging
- Bioactive Compounds and Antitumor Agents
- Analytical Chemistry and Chromatography
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Biochemical Acid Research Studies
- Synthesis of Organic Compounds
- Antimicrobial agents and applications
- Curcumin's Biomedical Applications
- Conducting polymers and applications
- Chemical synthesis and pharmacological studies
- Graphene and Nanomaterials Applications
- Chemistry and Chemical Engineering
Grigore T. Popa University of Medicine and Pharmacy
2014-2024
Alexandru Ioan Cuza University
2019
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug that mainly works by reducing insulin resistance, while curcumin (Cur) powerful antioxidant important hypoglycemic effect. Both drugs are associated several drawbacks, such as reduced bioavailability short half-life time (Pio), well instability poor water solubility (Cur), which limit their therapeutic...
The xanthine structure has proved to be an important scaffold in the process of developing a wide variety biologically active molecules such as bronchodilator, hypoglycemiant, anticancer and anti-inflammatory agents. It is known that hyperglycemia generates reactive oxygen species which are involved progression diabetes mellitus its complications. Therefore, development new compounds with antioxidant activity could therapeutic strategy against this metabolic syndrome. New thiazolidine-4-one...
Abstract Background Aryl-propionic acid derivatives with ibuprofen as representative drug are very important for therapy, being recommended especially anti-inflammatory and analgesic effects. On other hand 1,3-thiazolidine-4-one scaffold is an heterocycle, which associated different biological effects such analgesic, antioxidant, antiviral, antiproliferative, antimicrobial etc. The present study aimed to evaluated the toxicity degree of new ibuprofen. Methods For evaluation degree, cell...
New thiazolidine-4-one derivatives of 2-(4-isobutylphenyl)propionic acid (ibuprofen) have been synthesized as potential anti-inflammatory drugs. The structure the new compounds was proved using spectral methods (FR-IR, 1H-NMR, 13C-NMR, MS). in vitro antioxidant evaluated according to total activity, DPPH and ABTS radical scavenging assays. Reactive oxygen species (ROS) free radicals are considered be involved many pathological events like diabetes mellitus, neurodegenerative diseases,...
l-Arginine is a semi-essential aminoacid with important role in regulation of physiological processes humans. It serves as precursor for the synthesis proteins and also substrate different enzymes such nitric oxide synthase. This amino-acid act free radical scavenger, inhibits activity pro-oxidant thus acts an antioxidant has bactericidal effect against broad spectrum bacteria.New thiazolidine-4-one derivatives nitro-l-arginine methyl ester (NO2-Arg-OMe) have been synthesized biologically...
In the past many research studies have focused on thiazolidine-4-one scaffold, due to important biological effects associated with its heterocycle. This scaffold is present in structure of synthetic compounds, which showed significant such as antimicrobial, antifungal, antioxidant, anti-inflammatory, analgesic, antidiabetic effects. It was also identified natural actithiazic acid, isolated from Streptomyces strains. Starting this new xanthine derivatives been synthetized and evaluated for...
New thiazolidine-4-one derivatives based on the 4-aminophenazone (4-amino-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one) scaffold have been synthesized as potential anti-inflammatory drugs. The pyrazoline are known especially for their antipyretic, analgesic and effects, but recently there were new compounds with important antioxidant, antiproliferative, anticancer antidiabetic activities. beneficial effects of these explained by nonselective inhibition cyclooxygenase izoenzymes, also scavenging...
This work reports the design of [1,3,4]thiadiazolo[3′,2′:1,2]imidazo[4,5-c]quinolines using a Pictet–Spengler reaction. The scope reaction was achieved from 6-(2-aminophenyl)imidazo[2,1-b][1,3,4]thiadiazole derivatives and available aldehydes. A wide range aldehydes were employed to examine cyclization. In parallel, mechanism investigation realized showed hydride transfer which led dismutation intermediate species. To complete this methodological study, "sequential" oxidation/SNAr procedure...
Pesticide poisoning in pediatric patients is still an important reason for presenting to the emergency department Romania. In this context, present study aims raise awareness of toxicological impact pesticides on human health pediatrics. For purpose, demographic characteristics, clinical assessment, and outcome with acute pesticide admitted toxicology "Saint Mary" Emergency Children's Hospital from Iasi, were analyzed. This retrospective focused laboratory data aged under 18 years diagnosed...
The aim of the study was to optimize synthesis diclofenac derivative with hydrazones structure in order obtain higher yields and purity by variation different parameters such as: ratio between reactants, solvent, catalyst, temperature, time reaction method used. anti-inflammatory effects derivatives were evaluated using vitro assays: albumin denaturation erythrocyte membrane stability. obtained results showed that effect tested is increasing concentration, best being at concentration 125...
Generally, NSAIDs are weakly soluble in water and contain both hydrophilic hydrophobic groups. One of the most widely used is ibuprofen, which has a poor solubility high permeability profile. By creating dynamic, non-covalent, water-soluble inclusion complexes, cyclodextrins (CDs) can increase dissolution rate low aqueous drugs, operating as drug delivery vehicle, additionally contributing significantly to chemical stability pharmaceuticals reducing drug-related irritability. In order...
The synthesis of a new xanthine nitric oxide donor (TSP-81) has been discussed. designed compound includes two structural moieties - theophylline (1,3-dimethylxanthine) and acetaminophen (4-hydroxyacetanilide) linked by the alkyl chain as spacer. characterized microanalysis (CHN), 1H-NMR, 13C-NMR, FT-IR, UV-vis, TG DTG. thermal behaviour showed that TSP-81 melts with decomposition, in four steps, most important ones being 2nd one (the registered weight loss 17.6 %) 3rd (with 30.4 %)....
Type 2 Diabetes Mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement oxidative stress in its onset and progression. Pioglitazone (Pio) an antidiabetic drug which primarily works by reducing insulin resistance while Curcumin (Cur) powerful antioxidant o important hypoglycemic effect, also. The both drugs are associated several drawbacks, such as reduced bioavailability, short half-life time well instability poor water solubility (Cur), limit their...
Drug-drug interactions are a major cause of adverse reactions in polypharmacy, the incidence being directly proportional to number associated drugs. In this work, we highlighted main drug-drug that occurred treatment gastrointestinal symptoms with proton pump inhibitors and histamine H2-receptor antagonists. The two groups agents, used gastroesophageal reflux ulcer disease, can be released without prescription on recommendation pharmacist, contributing risk emergence interactions. occur due...